5-allyl 6,7-dimethoxy 1,3-benzodioxole (dillapiole)

a plant based insecticide; structure in first source

Also Known As:

dillapiole; 1-allyl-2,3-dimethoxy-4,5-(methylenedioxy)benzene; 2-methyl-5-(1-methylethenyl)-1,3-benzodioxole; dillapiol; 1,3-Benzodioxole, 4,5-dimethoxy-6-(2-propen-1-yl)-

Networked: 11 relevant articles (2 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 140
- Hydrocarbons: 1726
  - Acyclic Hydrocarbons
    - Alkenes: 270
      - Allyl Compounds: 7
        5-allyl 6,7-dimethoxy 1,3-benzodioxole: 11
Heterocyclic Compounds: 207
- 1-Ring Heterocyclic Compounds
  - Dioxoles
    - 5-allyl 6,7-dimethoxy 1,3-benzodioxole: 11

Experts

1.	Rafael, Míriam Silva: 2 articles (01/2020 - 09/2016)
2.	Chan, Wen-Hsiung: 2 articles (10/2015 - 06/2014)
3.	Gupta, Jeena: 1 article (04/2024)
4.	Khurana, Navneet: 1 article (04/2024)
5.	Shafi, Sana: 1 article (04/2024)
6.	Ho, Keat Lam: 1 article (01/2022)
7.	Kuppusamy, Umah Rani: 1 article (01/2022)
8.	Massawe, Festo: 1 article (01/2022)
9.	Ng, Zhi Xiang: 1 article (01/2022)
10.	Ngo, Chek Tung: 1 article (01/2022)

Related Diseases

1.	Malaria 09/01/2009 - "Dillapiole showed a fungicide action against the fungus Clinipellis perniciosa (witches' broom) by inhibition of its basidiospores, in concentrations ranging from 0.6 to 1.0 ppm. The larvicide and insecticide actions of dillapiole were tested against the larvae and the adult insects of Anopheles marajoara and Aedes aegypti (malaria and dengue mosquitoes), resulting in mortality of the larvae (48 h, 100%) at a concentration of 100 ppm, and mortality of the insects (30 min, 100%) at a concentration of 600 ppm. The isomeric isodillapiole showed no significant activity in the same biological tests." 01/01/2021 - "Between the acaricidal, antiparasitic and synergistic activities, the insecticidal effects are highly promising, with optimal results against the malaria vector Aedes aegypti, with an LC50 that ranges between 57 and 200μg/mL. Acaricidal activity has mainly been reported against Tetranychus urticae, showing an LC50 that ranges between 5.83 and 7.17μg/mL. Antiparasitic activity has predominately been found on Leishmania amazonensis, and antipromastigote activity has been found to be between 23.8 and 25.9μg/mL. Concerning the synergistic effect between dillapiole and synthetic insecticides, four studies on Spodoptera frugiperda found promising results with cypermethrin. "
2.	Diabetic Nephropathies (Diabetic Nephropathy) 04/02/2024 - "PPAR gamma agonistic activity of dillapiole: protective effects against diabetic nephropathy."
3.	Neoplasms (Cancer) 04/01/2014 - "Molecular modeling studies corroborated the biological findings and suggested that dillapiole may present a good pharmacokinetic profile, mainly because its hydrophobic character, which can facilitate its diffusion through tumor cell membranes. " 04/01/2014 - "We also demonstrated that dillapiole exhibits anti-proliferative properties, arresting cells at the G0/G1 phase and its antimigration effects can be associated with the disruption of actin filaments, which in turn can prevent tumor cell proliferation. " 04/01/2014 - "Here, we have demonstrated for the first time that dillapiole has broad cytotoxic effects against a variety tumor cells. "
4.	Dengue (Dengue Fever) 01/01/2008 - "The insecticidal activity of dillapiol was tested in vivo on the larvae and pupae of Aedes aegypti, the mosquito vector of dengue. " 01/01/2020 - "Dillapiole n-butyl ether is a substance derived from dillapiole, which exhibits potential insecticidal effects on Aedes aegypti, the principal vector of the Dengue fever, Zika, and Chikungunya viruses, as well as Aedes albopictus, a vector of Dengue fever. " 09/01/2009 - "Dillapiole showed a fungicide action against the fungus Clinipellis perniciosa (witches' broom) by inhibition of its basidiospores, in concentrations ranging from 0.6 to 1.0 ppm. The larvicide and insecticide actions of dillapiole were tested against the larvae and the adult insects of Anopheles marajoara and Aedes aegypti (malaria and dengue mosquitoes), resulting in mortality of the larvae (48 h, 100%) at a concentration of 100 ppm, and mortality of the insects (30 min, 100%) at a concentration of 600 ppm. The isomeric isodillapiole showed no significant activity in the same biological tests." 09/01/2016 - "Two derivatives of dillapiole, dillapiole ethyl ether (1KL39-B) and butyl ether-n dillapiole (1KL43-C), were studied for their toxicity and genotoxicity against Aedes albopictus, to help develop new strategies for the control of this potential vector of dengue and other arboviruses, because it is resistant to synthetic insecticides. "
5.	Fetal Weight 10/01/2015 - "Pre-incubation of oocytes with dillapiole during in vitro maturation led to an increase in post-implantation embryo resorption and decrease in mouse fetal weight. " 06/13/2014 - "Moreover, in vitro treatment with 2.5-10 μM dillapiole was associated with increased resorption of post-implantation embryos and decreased fetal weight. "

Related Drugs and Biologics

1.	Insecticides
2.	Antiparasitic Agents (Antiparasitics)
3.	cypermethrin (alphamethrin)
4.	PPAR gamma
5.	Mitogen-Activated Protein Kinases
6.	Phytol
7.	Ether (Diethyl Ether)
8.	Ellagic Acid
9.	Carrageenan
10.	pellucidin A