Histopathological, cytotoxicological, and genotoxic effects of the semi-synthetic compound dillapiole n-butyl ether in Balb/C mice.

Abstract

Dillapiole n-butyl ether is a substance derived from dillapiole, which exhibits potential insecticidal effects on Aedes aegypti, the principal vector of the Dengue fever, Zika, and Chikungunya viruses, as well as Aedes albopictus, a vector of Dengue fever. As these mosquitoes are resistant to synthetic insecticides, dillapiole n-butyl ether may represent a valuable, plant-based alternative for their control. Dillapiole n-butyl ether has insecticidal and genotoxic effects on A. aegypti and A. albopictus, as shown by the reduction in clutch size and egg viability, and increased mortality rates, as well as a high frequency of micronuclei and chromosomal aberrations. However, the potential cytotoxic and genotoxic effects of this substance in mammals are still unknown. In Balb/C mice, structural changes were detected in hepatic, renal, and cardiac tissues, which were directly proportional to the concentration of the dose applied, in both genders. The induction of genotoxic, mutagenic, and cytotoxic effects was also observed at the highest concentrations (150 and 328 mg/kg). Further research will be necessary to better characterize the potential genotoxicity of this substance at lower concentrations, for the evaluation of the potential health risks related to its presence in environmental features, such as drinking water.

• Authors: Daniel Luís Viana Cruz, Tania Cristina Sumita, Mayla Silva Leão Ferreira, Junielson Soares da Silva, Ana Cristina da Silva Pinto, José Fernando Marques Barcellos, Míriam Silva Rafael
• Journal: Journal of toxicology and environmental health. Part A (J Toxicol Environ Health A) Vol. 83 Issue 17-18 Pg. 604-615 (09 16 2020) ISSN: 1528-7394 [Print] England
• PMID: 32787530 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Allyl Compounds
• Dioxoles
• 5-allyl 6,7-dimethoxy 1,3-benzodioxole

Topics

• Allyl Compounds (administration & dosage, toxicity)
• Animals
• Cell Survival (drug effects)
• DNA Damage (drug effects)
• Dioxoles (administration & dosage, toxicity)
• Dose-Response Relationship, Drug
• Female
• Heart (drug effects)
• Kidney (drug effects)
• Liver (drug effects)
• Male
• Mice
• Mice, Inbred BALB C
• Mutagenicity Tests
• Piper