Abstract |
Two derivatives of dillapiole, dillapiole ethyl ether (1KL39-B) and butyl ether-n dillapiole (1KL43-C), were studied for their toxicity and genotoxicity against Aedes albopictus, to help develop new strategies for the control of this potential vector of dengue and other arboviruses, because it is resistant to synthetic insecticides. Eggs and larvae exposed to different concentrations of 1KL39-B (25, 30, 50, 70, and 80μg/mL) and of 1KL43-C (12.5, 20, 25, 30 and 40μg/mL) exhibited toxicity and susceptibility, with 100% mortality. The LC50 was 55.86±1.57μg/mL for 1KL39-B and 25.60±1.24μg/mL for 1KL43-C, while the LC90 was 70.12μg/mL for 1KL39-B and 41.51μg/mL for 1KL43-C. The gradual decrease in oviposition of the females of the G1 to G4 generations was proportional to the increase in concentrations of these compounds, which could be related to the cumulative effect of cell anomalies in neuroblasts and oocytes (P<0.05), including micronuclei, budding, multinucleated cells and nuclear bridges. These findings showed that both 1KL39-B and 1KL43-C can serve as potential alternatives in the control of A. albopictus.
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Authors | Sabrina da Fonseca Meireles, Pedro Rauel Cândido Domingos, Ana Cristina da Silva Pinto, Míriam Silva Rafael |
Journal | Mutation research. Genetic toxicology and environmental mutagenesis
(Mutat Res Genet Toxicol Environ Mutagen)
Vol. 807
Pg. 1-7
(Sep 01 2016)
ISSN: 1879-3592 [Electronic] Netherlands |
PMID | 27542709
(Publication Type: Journal Article)
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Copyright | Copyright © 2016. Published by Elsevier B.V. |
Chemical References |
- Allyl Compounds
- Dioxoles
- Insecticides
- Mutagens
- dillapiole ethyl ether
- dillapiole n-butyl ether
- 5-allyl 6,7-dimethoxy 1,3-benzodioxole
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Topics |
- Aedes
(drug effects)
- Allyl Compounds
- Animals
- DNA Damage
- Dioxoles
(chemical synthesis, toxicity)
- Female
- Insecticides
(chemical synthesis, toxicity)
- Larva
(drug effects)
- Mutagens
(chemical synthesis, toxicity)
- Oocytes
(drug effects)
- Oviposition
(drug effects)
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