Antiviral effect of 3-[bis-(2-hydroxyethyl)-amino]-acetophenone-[4,5-diphenyl-oxyazolyl-(2)]hydrazone (IMET 98/69) in mice.

Abstract

The potential in vivo antiviral activity of 3-[bis-(2-hydroxyethyl)-amino]-acetophenone-[4,5-diphenyl-oxazolyl-(2)]-hydrazone (IMET 98/69) was evaluated on model infections in mice. Animals treated subcutaneously (s.c.) with 1 mmole of the drug per kg body weight once daily for five days were significantly protected against a lethal infection with cardioviruses, Semliki forest virus and vaccinia virus. In influenza A and B virus models no antiviral activity was observed either after s.c. or oral treatment.

• Authors: A Veckenstedt, M K Indulen, D Dzeguse, I Zgórniak-Nowosielska, I Mécs, I Béládi
• Journal: Acta virologica (Acta Virol) Vol. 23 Issue 6 Pg. 500-3 (Nov 1979) ISSN: 0001-723X [Print] Slovakia
• PMID: 44666 (Publication Type: Journal Article)

Chemical References

• Antiviral Agents
• Oxazoles
• IMET 98-69

Topics

• Administration, Oral
• Animals
• Antiviral Agents (administration & dosage, therapeutic use)
• Arbovirus Infections (prevention & control)
• Disease Models, Animal
• Drug Evaluation, Preclinical
• Encephalomyocarditis virus
• Enterovirus Infections (prevention & control)
• Female
• Injections, Subcutaneous
• Male
• Mice
• Orthomyxoviridae Infections (prevention & control)
• Oxazoles (analogs & derivatives, therapeutic use)
• RNA Viruses
• Semliki forest virus
• Vaccinia (prevention & control)
• Virus Diseases (prevention & control)