Severe life-threatening hypersensitivity reaction to polidocanol in a case of recurrent aneurysmal bone cyst.

Abstract

Aneurysmal bone cysts (ABC) are expansile lytic lesions constituting around 1% of all benign bone tumors with an annual incidence of 1.4/100000. A variety of treatments are available ranging from curettage with or without bone grafting (autologous or allogeneic), curettage with use of adjuvants [Polymethylmethacrylate (PMMA) bone cement, high speed burr, phenol, liquid nitrogen], wide en-block excision with or without reconstruction, selective arterial embolization of the feeding vessels, radiation therapy, high precision megavoltage radiotherapy and percutaneous radio-nuclide ablation, sclerotherapy (ethibloc, aetoxisclerol, alcohol gel, polidocanol). The optimal treatment is debatable due to various indications and contraindications of different modalities of treatment. Recent data suggest that percutaneous sclerotherapy with polidocanol is safe and effective alternative to surgery for treatment of ABCs as it has minimal side effects. We are reporting the first case of life-threatening adverse reaction to intra-lesional polidocanol in a three-year-old boy with a proximal femoral aneurysmal bone cyst. The importance of reporting this case is to make people aware regarding the adverse reaction of polidocanol and to highlight the precautions one should follow while using polidocanol for aneurysmal bone cysts.

• Authors: Gaurav Gupta, Ram Sagar Pandit, Nameet Jerath, Ramani Narasimhan
• Journal: Journal of clinical orthopaedics and trauma (J Clin Orthop Trauma) 2019 Mar-Apr Vol. 10 Issue 2 Pg. 414-417 ISSN: 0976-5662 [Print] India
• PMID: 30828217 (Publication Type: Case Reports)