Abstract | BACKGROUND: METHODS: RESULTS: In the model of acute colitis, indirubin treatment improved the loss of body weight. Histology of colonic tissue revealed that indirubin treatment improved the histology grading of colitis (P = 0.02), the extent of submucosal fibrosis (P = 0.018), the number of mucosal toluidine blue-positive cells (P = 0.004) and colon length (P = 0.01). In the model of chronic colitis, indirubin treatment had no significant effect on pathologic findings except for colon length (P = 0.003). However, indirubin administration significantly reduced colon levels of interleukin-6 in the chronic- colitis model (P = 0.001). CONCLUSION:
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Authors | Naruo Tokuyasu, Kohei Shomori, Kuniki Amano, Soichiro Honjo, Teruhisa Sakamoto, Joji Watanabe, Masataka Amisaki, Masaki Morimoto, Ei Uchinaka, Takuki Yagyu, Hiroaki Saito, Hisao Ito, Yoshiyuki Fujiwara |
Journal | Yonago acta medica
(Yonago Acta Med)
Vol. 61
Issue 2
Pg. 128-136
(Jun 2018)
ISSN: 0513-5710 [Print] Japan |
PMID | 29946219
(Publication Type: Journal Article)
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