CGP 6809, a sugar-containing nitrosourea derivative: pharmacological and physicochemical properties.

Abstract

CGP 6809 is a water-soluble nitrosourea derivative with quite distinct chemical and biological properties as compared with the well-known representatives of this class of compounds. It is related to the antibiotic streptozotocin, from which it is distinguished in the structure of the sugar moiety and the position of the methylnitrosourea residue. CGP 6809 possesses practically the same alkylating potential as streptozotocin; however, its carbamoylating activity is comparable with that of CCNU. In contrast to other nitrosourea derivatives, CGP 6809 showed relatively little activity in murine leukemias but was markedly active in solid transplantable melanomas (Harding-Passay, B16), in the 11095 prostate carcinoma, and in a substrain of Yoshida hepatoma (AH 7974) resistant to BCNU and CCNU. In the Ehrlich and Yoshida ascitic tumors complete responses were seen with no toxic death. Dose-dependent activity was found in the human lung carcinoma MBA 9812 and almost complete growth inhibition was achieved in the human melanoma WM 47 by both the oral and parenteral routes of administration. However, mammary tumor lines (Ca 755, 2661/61, R-3230AC), the Guerin-T8 uterus epithelioma, and the Rous sarcoma/S-R proved to be relatively refractory to this drug. This was also the case for the Lewis lung carcinoma implanted i.m. or s.c. However, development of lung metastases was markedly inhibited. Combination therapy using CGP 6809 with cyclophosphamide, 5-fluorouracil, or chlorambucil in the same model led to partial responses of the primary tumor as well as almost total eradication of lung metastases.

• Authors: K Schieweck, J Stanek, P M Kanter, K H Schmidt-Ruppin, M Müller, A Matter
• Journal: Cancer chemotherapy and pharmacology (Cancer Chemother Pharmacol) Vol. 23 Issue 6 Pg. 341-7 ( 1989) ISSN: 0344-5704 [Print] Germany
• PMID: 2713956 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antineoplastic Agents
• Nitrosourea Compounds
• CGP 6809

Topics

• Alkylation
• Animals
• Antineoplastic Agents (therapeutic use, toxicity)
• Cell Line
• Chemical Phenomena
• Chemistry
• Drug Stability
• Female
• Leukemia, Experimental (drug therapy, pathology)
• Male
• Mice
• Mice, Inbred ICR
• Neoplasms, Experimental (drug therapy, pathology)
• Nitrosourea Compounds (therapeutic use, toxicity)
• Rats