Abstract | AIM: METHODS: ZDF rats at 12 weeks of age were treated for 12 weeks with AVE7688 (500 mg/kg diet). Afterwards, vascular reactivity of epineurial arterioles of the sciatic nerve and nerve conduction velocity and blood flow was determined. RESULTS: Vascular and neural function was significantly impaired in ZDF rats compared with age-matched lean (control) rats. Treating ZDF rats with AVE7688 improved vascular relaxation to acetylcholine and calcitonin gene-related peptide in epineurial arterioles. Motor and sensory nerve conduction velocity, endoneurial blood flow and thermal nociception end-points were also improved by treatment compared with untreated ZDF rats. Superoxide and expression of NEP were increased in epineurial arterioles from ZDF rats and attenuated by treatment with AVE7688. CONCLUSIONS:
|
Authors | C L Oltman, E P Davidson, L J Coppey, T L Kleinschmidt, M A Yorek |
Journal | Diabetes, obesity & metabolism
(Diabetes Obes Metab)
Vol. 11
Issue 3
Pg. 223-33
(Mar 2009)
ISSN: 1463-1326 [Electronic] England |
PMID | 18564175
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
|
Chemical References |
- AVE 7688
- Angiotensin-Converting Enzyme Inhibitors
- Enzyme Inhibitors
- Heterocyclic Compounds, 3-Ring
- Hypoglycemic Agents
- Neprilysin
|
Topics |
- Angiotensin-Converting Enzyme Inhibitors
(therapeutic use)
- Animals
- Blood Flow Velocity
(drug effects)
- Diabetes Mellitus, Type 2
(drug therapy, physiopathology)
- Diabetic Angiopathies
(drug therapy, physiopathology)
- Diabetic Neuropathies
(drug therapy, physiopathology)
- Enzyme Inhibitors
(therapeutic use)
- Heterocyclic Compounds, 3-Ring
(therapeutic use)
- Hypoglycemic Agents
(therapeutic use)
- Male
- Neprilysin
(antagonists & inhibitors)
- Neural Conduction
(drug effects, physiology)
- Rats
- Rats, Zucker
- Sciatic Nerve
(drug effects, physiopathology)
|