[Monogenic hypertension].

Abstract

Four types of monogenic hypertension belong to the group of mineralocorticoid hypertension, which are characterized by high renal water and sodium retention and resulting suppression of plasma renin activity (PRA), high urinary potassium secretion and consecutive low plasma potassium:1. increased production of the hormone aldosterone: glucocorticoid-remediable aldosteronism (GRH), 2. prereceptor disorder with loss of selectivity of the mineralocorticoid receptor: apparent mineralocorticoid excess (AME), 3. receptor disorder with constitutive activation of the mineralocorticoid receptor: "Geller syndrome", 4. postreceptor disorder with enhanced function of the epithelial sodium channel: Liddle's syndrome. While in GRH high synthesis of aldosterone results in high plasma aldosterone and low PRA, in the primary renal malfunctions of the AME, constitutive activation of the mineralocorticoid receptor and the Liddle's syndrome both plasma aldosterone and PRA are low. These forms of hypertension are rather rare in their complete expression, but they point to candidate genes whose mutations may predispose to hypertension. A point mutation of the ENaC beta-subunit (T594M) occurs rather frequent in people of African origin, with 5%. Therefore it is suggested to analyze the genotype of black hypertensive patients as a prerequisite for a rational amiloride therapy. Contrarily, the rather frequent (A[2139]G) polymorphism of the promoter of the alpha-subunit is supposed to mark a lower risk of hypertension. Mutations in the serine-threonine kinases WNK1 or WNK4 cause pseudohypoaldosteronism type II. WNK1 and WNK4 are expressed in the distal part of the nephron. Stimulation of sodium reabsorption by aldosterone is normal but without influence on hyperkalemia. An extrarenal disorder is suggested to be the cause of autosomal-dominant hypertension with brachydactyly: the patients react with a severely impaired baroreflex und show neurovascular contact. The mutation causing this syndrome is not known.

• Authors: Volker Bähr, Wolfgang Oelkers, Sven Diederich
• Journal: Medizinische Klinik (Munich, Germany : 1983) (Med Klin (Munich)) Vol. 98 Issue 4 Pg. 208-17 (Apr 15 2003) ISSN: 0723-5003 [Print] Germany
• Vernacular Title: Monogenetische Hypertonien.
• PMID: 12715144 (Publication Type: Comparative Study, English Abstract, Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Mineralocorticoids
• Receptors, Mineralocorticoid
• Sodium Channels
• Aldosterone
• Renin

Topics

• Adolescent
• Adult
• Aldosterone (blood)
• Child
• Female
• Genes, Dominant
• Genotype
• Humans
• Hyperaldosteronism (complications, genetics, physiopathology)
• Hypertension (blood, drug therapy, etiology, genetics, physiopathology)
• Male
• Mineralocorticoids (genetics)
• Phenotype
• Point Mutation
• Polymorphism, Genetic
• Pseudohypoaldosteronism (genetics, physiopathology)
• Receptors, Mineralocorticoid (genetics, physiology)
• Renin (blood)
• Risk Factors
• Sodium Channels (physiology)
• Syndrome