HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

Hypertension (High Blood Pressure)

Subscribe to New Research on Hypertension

Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.

Also Known As:

High Blood Pressure; Blood Pressures, High; High Blood Pressures; Blood Pressure, High

Networked: 87082 relevant articles (4514 outcomes, 12090 trials/studies) for this Disease, Comments

Relationship Network

Disease Context: Research Results

Cardiovascular Diseases: 28068
- Vascular Diseases: 8888
  - Hypertension: 87082

Related Diseases

1.	Heart Failure
2.	Stroke (Strokes)
3.	Obesity
4.	Cardiovascular Diseases (Cardiovascular Disease)
5.	Diabetes Mellitus

Experts

1.	Dahlöf, Björn: 78 articles (09/2012 - 02/2002)
2.	Devereux, Richard B: 76 articles (10/2012 - 03/2002)
3.	Oparil, Suzanne: 57 articles (10/2012 - 02/2002)
4.	Schiffrin, Ernesto L: 54 articles (03/2012 - 01/2002)
5.	Kjeldsen, Sverre E: 51 articles (10/2012 - 03/2002)
6.	Touyz, Rhian M: 49 articles (08/2011 - 01/2002)
7.	Wachtell, Kristian: 41 articles (09/2012 - 02/2002)
8.	Schmieder, Roland E: 40 articles (01/2013 - 01/2002)
9.	Ogihara, Toshio: 40 articles (08/2012 - 01/2002)
10.	Johnson, Richard J: 40 articles (02/2012 - 02/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hypertension:

1.	Hydrochlorothiazide (Esidrix)FDA LinkGeneric 11/01/2010 - "Study results demonstrate that OM ± hydrochlorothiazide is highly effective in reducing BP while enabling a majority of patients with stage 1 hypertension to achieve BP goal. " 11/01/2009 - "Aml 10 mg/Val 320 mg/HCTZ 25 mg triple therapy is highly effective in reducing BP compared with dual components early in therapy, and systolic BP-lowering effects were proportionate to hypertension severity." 10/01/2012 - "Adding HCTZ to a range of OLM/AML dose combinations is well tolerated and improved BP control by significantly lowering DBP and SBP and significantly increasing BP threshold achievement in patients with moderate-to-severe hypertension. " 07/14/1998 - "Hydrochlorothiazide was associated with greater overall reduction of left atrial size than other drugs effective for the treatment of hypertension. " 01/01/2007 - "The authors conclude that an OM-based regimen, with or without HCTZ in conventional doses, is effective in controlling and normalizing BP in stage 2 systolic hypertension." Order ALL the reference details at left...
2.	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 03/01/2000 - "Are angiotensin-converting enzyme inhibitors the best treatment for hypertension in type 2 diabetes?" 09/01/2006 - "Angiotensin-converting enzyme inhibitors have been shown to provide excellent organ protection in hypertension, and may show dose-dependent protective effects. " 08/01/2001 - "Inasmuch as AT1 receptor antagonists have proven themselves the equals of angiotensin converting enzyme inhibitors with respect to antihypertensive efficacy, but demonstrated better safety profiles, this class of drugs may be considered to be a qualitative improvement in the treatment of essential hypertension. " 04/01/1990 - "The ACE inhibitors are assuming a dominant role in our therapeutic armamentarium, in that they are well-tolerated and very effective in the treatment of mild, moderate or severe hypertension." 11/01/2006 - "Interventional studies have shown that partial correction of anaemia through epoetin, together with an arterial hypertension successful therapy through renin-angiotensin system acting drugs, such as ACE-inhibitors, were able to induce a LVH regression in CKD. " Order ALL the reference details at left...
3.	CalciumIBA 11/01/2001 - "Specifically, in the Systolic Hypertension in Europe study, compared with placebo, a calcium antagonist dramatically reduced cardiovascular (CV) events in elderly diabetics. " 11/12/1998 - "If the results of the FACET and ABCD studies are considered in the context of the best available data arising from large randomized controlled trials, one may conclude that calcium antagonists are not harmful or contraindicated in hypertensive patients with diabetes and that the combination of an ACE inhibitor and a calcium antagonist is effective for the management of hypertension in diabetic patients." 02/01/2010 - "Medical treatment essentially calcium blockers improved hypertension in most cases. " 09/01/1995 - "All calcium antagonists have been shown to be effective in hypertension and most have a protective effect on the target organs. " 03/01/2002 - "Calcium antagonists represent an important group of drugs for the treatment of hypertension; they are effective in the whole range of severity of the disease. " Order ALL the reference details at left...
4.	Antihypertensive Agents (Antihypertensives)IBA 10/01/2003 - "We conclude that the combination of event reduction from large-scale clinical trials, adequate 24 h BP reduction, and improved tolerability compared to most other classes of anti-hypertensive agents, make the ARBs a suitable initial treatment for patients with hypertension." 08/18/2007 - "Despite the availability of effective and safe antihypertensive drugs, hypertension and its concomitant risk factors remain uncontrolled in most patients." 02/01/2005 - "Although several anti-hypertensive agents have shown to be effective in the treatment of hypertension, adequate blood pressure control is not frequent in most populations. " 08/01/2001 - "It is apparent that most available classes of antihypertensive agents can be effective in the management of hypertension, if used appropriately by providers, in conjunction with optimal adherence with prescribed medications by patients." 04/01/2008 - "(1) Pharmacological management of arterial hypertension is based on antihypertensive drugs with proven efficacy on morbidity and/or mortality endpoints. " Order ALL the reference details at left...
5.	Captopril (Capoten)FDA LinkGeneric 01/01/1991 - "The largest and best known study, of 625 white men with mild hypertension, reported that patients given captopril showed a significant improvement after 6 months in general well-being, work performance, and those skills associated with cognitive function. " 02/01/1993 - "Thus, of the drugs tested, captopril appears to be the best option as third drug in hypertension." 10/01/1987 - "The ACE inhibitor captopril was most effective in the control of hypertension. " 01/01/1986 - "These data suggest that captopril is highly effective for blood pressure control and that the neurohormonal responses to the drug probably provide additional benefits for long-term therapy in hypertension." 06/01/1981 - "Captopril was helpful in the management of refractory hypertension in most cases." Order ALL the reference details at left...
6.	Nifedipine (Adalat)FDA LinkGeneric 01/01/1998 - "The results obtained show that Adalat in dosage 60 mg daily during 7 days is most effective in cases with concomitant border-line hypertension. " 01/01/1991 - "Nifedipine turned out most effective in patients of functional class II with arterial hypertension." 01/01/2007 - "The dose-dependent increased efficacy and the markedly improved safety profile of bedtime as compared to morning administration of nifedipine GITS should be taken into account when prescribing this CCB in the treatment of essential hypertension." 12/01/1987 - "In hypertension a similar antihypertensive effect to nifedipine has been found, while a significantly greater lowering of blood pressure was seen than that obtained with a diuretic. " 01/01/1986 - "The efficacy of corinfar therapy was higher in the patients with hypertension with a high initial tension of the peripheral vessels." Order ALL the reference details at left...
7.	Amlodipine (Norvasc)FDA LinkGeneric 01/01/2011 - "In this open-label, single-arm switch study reflecting clinical practice, patients with moderate hypertension not controlled by the free combination of CAN 32 + HCT 25 achieved a clinically and statistically significant reduction of blood pressure from the single pill combination of ALIS 300/HCT 25, and the optional addition of amlodipine." 09/01/2007 - "The clinical efficacy of amlodipine in improving hemodynamic variables and reducing cardiovascular events in isolated systolic hypertension could be explained by its beneficial effect on vascular calcification. " 12/01/2000 - "Once-daily amlodipine was effective in the treatment of mild to moderate hypertension in this patient population and demonstrated a low frequency of adverse events, a high degree of tolerability, and improved well-being. " 11/01/1996 - "Amlodipine has a beneficial effect on LVH and also is an effective and safe drug to treat mild to moderate hypertension." 05/01/1999 - "Higher doses of amlodipine were required for younger patients, and monotherapy was effective in patients with essential hypertension." Order ALL the reference details at left...
8.	ReninIBA 11/01/1985 - "Hypertension was cured dramatically and plasma renin activity was within the normal range after the operation. " 11/01/1980 - "Patients with renin-dependent hypertension had dramatic reduction in blood pressure in most instances; 90% were cured or improved. " 12/01/1989 - "Clinical studies have proved their efficacy, safety, and good tolerability alone or in combination with other drugs in uncomplicated hypertension in which they are particularly effective in older, low renin, and possibly, black patients. " 01/01/1988 - "Clinical studies have proved their efficacy, safety, and good tolerability alone or in combination with other drugs in uncomplicated hypertension where they are particularly effective in older and low-renin and possibly black patients. " 10/01/1987 - "In this study, a significant reduction of u-cDA and of u-tDA was also found in those patients with low renin essential hypertension. " Order ALL the reference details at left...
9.	Enalapril FDA LinkGeneric 01/01/1993 - "Enalapril and high-dose DuP were almost equally effective in controlling systemic hypertension. " 06/01/1986 - "In group 2 rats, treatment with enalapril prevented systemic hypertension and maintained delta P at near-normal levels without significant reduction in SNGFR and QA. " 12/01/1984 - "In conclusion, enalapril monotherapy reduces blood pressure in two-thirds of patients with moderately severe essential hypertension at rest and during exercise, associated with a significant reduction in TPRI. " 10/01/1982 - "From these results it is concluded that MK 421 is a strong and long-acting antihypertensive drug and its clinical application seems very useful for the treatment of hypertension." 01/01/1985 - "Multiclinic controlled studies have shown that enalapril alone 10 to 40 mg/day orally is effective in lowering blood pressure in patients with essential hypertension. " Order ALL the reference details at left...
10.	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA 01/01/2001 - "The role of the renin-angiotensin-aldosterone system in the pathogenesis of hypertensive disease has long been recognized, and the interruption of this cascade with angiotensin-converting enzyme-I has been beneficial in the management of hypertension. " 12/19/1985 - "Long-term studies are needed to find out whether this angiotensin-converting enzyme inhibitor is superior to a diuretic as initial treatment of arterial hypertension." 11/01/1989 - "These findings suggested that urinary excretion of GAA may be a more sensitive marker than AER, BMG or NAG in hypertension and angiotensin-converting enzyme inhibitor and Ca entry blocker can be useful in the treatment of patients with essential hypertension with renal damage." 01/01/2010 - "Angiotensin-converting enzyme (ACE) inhibition (ACEi) ameliorates the development of hypertension and the intrarenal ANG II augmentation in ANG II-infused mice. " 01/01/2005 - "[Level of endothelial vasodilatation and activity of angiotensin converting enzyme as criterion of efficacy of therapy in patients with mild and moderate hypertension]." Order ALL the reference details at left...

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 01/01/2005 - "Although single drug therapy is effective in treating hypertension, most patients will require combination drug treatment. " 01/01/2002 - "Single-drug therapy, even when maximally titrated, is at best only modestly effective in normalising BP in Stage-I or II hypertension, which represents the majority of the hypertensive population. " 12/14/1996 - "A complete assessment based on medical results and cost effectiveness will undoubtedly confirm the usefulness of two-drug therapies as first line treatment for moderate hypertension." 06/15/2007 - "Pharmacy students showed significant improvement in clinical skills performance and in their knowledge of the pharmacotherapy of hypertension. " 07/01/1990 - "Basing on this evidence it would be beneficial for patients suffering from juvenile hypertension in need of chemotherapy to take courses of the above drugs." Order ALL the reference details at left...
2.	Nephrectomy 06/01/2000 - "After the control of arterial hypertension by nephrectomy, the patient had a complete remission of the symptoms, as well as the images anomalies." 10/15/1948 - "Marked hypertension in a child relieved by nephrectomy." 01/01/2009 - "Although there is some evidence to suggest nephrectomy is beneficial in treating hypertension in these patients (the patient in our case was on two anti hypertensive preparations), the patient did not want to consider surgery as her symptoms had settled spontaneously. " 12/01/1979 - "We believe these results indicate that despite the presence of severe renovascular disease, the affected kidney can be preserved and hypertension successfully relieved by a direct surgical approach without recourse to either nephrectomy or ex vivo reconstruction." 03/26/1977 - "Surgical treatment gives good results and our own case clearly indicates the immediate and definitive relief of hypertension by nephrectomy. " Order ALL the reference details at left...
3.	Transplants (Transplant) 09/01/1986 - "These findings imply that pretransplant disturbances in LV function are related more to factors such as hypertension, volume overload and uraemia than to diabetes per se because no pronounced improvement in the metabolic disorder resulting from diabetes can be expected, even after the most successful transplant. " 11/01/1998 - "Aorta-aortic bypass graft surgery was carried out successfully and hypertension remarkably improved. " 11/01/1988 - "Venous hypertension was significantly reduced by CFB (group II, p less than 0.025; group VI, p less than 0.001); increasing the diameter of the bypass conduit from 3 to 6 mm produced significantly greater graft flow (p less than 0.05), while completely relieving venous hypertension. " 06/27/2009 - "ABPM improved the diagnostic accuracy of arterial hypertension in RTRs and was the only effective tool in disclosing the association of BP with 1-year renal transplant outcome." 01/01/2004 - "A second renal transplant study, in adults, demonstrated similar rejection rates of 25% with improvement in post-transplant hypertension and lipid profiles. " Order ALL the reference details at left...
4.	Angioplasty (Angioplasty, Transluminal) 01/01/2007 - "The arterial dilatation through angioplasty of the accessory artery improved dramatically the control of his hypertension." 06/01/2010 - "Percutaneous transluminal angioplasty has long been considered the mainstay of therapy and offers high rates of improved or cured hypertension. " 11/01/2003 - "Successful angioplasty commonly results in improved control of hypertension, but an overall benefit on renal function and/or patient survival has not been shown. " 09/01/2001 - "A 13-year-old girl who recently developed hypertension was diagnosed to have an occluded right renal branch artery and was treated successfully with percutaneous transluminal angioplasty (PTA). " 05/01/1993 - "Following successful angioplasty there was significant improvement in hypertension (p < 0.001) within 48 hours. " Order ALL the reference details at left...
5.	Adrenalectomy 06/01/1995 - "4. Patients with adrenal causes of hypertension were cured or significantly improved by laparoscopic unilateral adrenalectomy. " 09/01/2012 - "Adrenalectomy cured hypertension in 44 patients (53.7%), and 27 patients (32.9%) had persistent hypertension that was much easier to control after surgery, whereas 11 patients (13.4%) had continued hypertension and poor blood pressure control. " 04/01/2012 - "Adrenalectomy cured hypertension in 68 patients (54.8%) and 43 (34.8%) had persistent hypertension that was much easier to control after surgery, whereas 13 patients (10.4%) had continued hypertension and poor blood pressure control. " 04/01/2012 - "Adrenalectomy cured hypertension in 68 (44%) patients. " 10/01/2011 - "Among the 45 patients who underwent unilateral adrenalectomy, 32 (71%) were cured of hypertension. " Order ALL the reference details at left...

blog comments powered by Disqus

TREATMENT OPTIONS
for Hypertension,
Ranking and Evidence

CureHunter Patient-Physician Summary Reports collect in one document all the medications ever reported in the US National Library of Medicine—1949 to the present—to be effective against your target disease. Analytic charts allow you and your physicians to see at a glance the treatment options—including new, promising, off-label and experimental.

Free Updates for 1 Year
All 4514 Outcomes
Top 200 Key Drugs and Biologics
Top 50 Key Therapies and Procedures
Detailed History Charts
Full Research Evidence References
Sample PDF Report on Psoriasis >>

Price:

$24.95 USD & Delivery via PDF download
updates for 1 year

Research Interface PRO

Rapidly retrieve clinical outcome summaries for all evidence of drug efficacy against any disease in seconds. Click "Charts" to view graphs of relative efficacy of all drugs against any known disease. CureHunter is unlike any "search engine" you have ever used. Where standard "search engines" produce lists of links, CureHunter quantifies evidence, extracts it from the literature and calculates a result you can use to immediately facilitate evidence based decision making in Real Clinical Time. Save hours of search and analysis time:

Two-clicks from Disease to Drug to Evidence: Drill down to full abstract
Enable Experts: Quickly identify key researchers and their publications
Enable FDA Link Generic: Two-clicks to FDA Products/Patents/Generics
Enable Export: All outcome statements and scores exportable to Excel/TSV for automated meta-analysis
Research Network: Explore drug and disease relationships visually
Enable Mobile Interface: Access from your cellphone, iPhone or PDA

Price:

$490.00 USD access via web interface
1 year subscription

Request Bulk Institution License Details >>