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Renin

A highly specific (Leu-Leu) endopeptidase that generates ANGIOTENSIN I from its precursor ANGIOTENSINOGEN, leading to a cascade of reactions which elevate BLOOD PRESSURE and increase sodium retention by the kidney in the RENIN-ANGIOTENSIN SYSTEM. The enzyme was formerly listed as EC 3.4.99.19.

Also Known As:

Big Renin; Cryorenin; Inactive Renin; Pre-Prorenin; Preprorenin; Prorenin; Angiotensin Forming Enzyme; Pre Prorenin; Renin, Big; Renin, Inactive; Angiotensin-Forming Enzyme; Angiotensinogenase

Networked: 9815 relevant articles (314 outcomes, 969 trials/studies) for this Bio-Agent, Comments

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Itoh, Hiroshi: 16 articles (09/2012 - 10/2003)
2.	Ichihara, Atsuhiro: 16 articles (07/2012 - 02/2002)
3.	Oparil, Suzanne: 11 articles (10/2012 - 07/2007)
4.	Calhoun, David A: 11 articles (01/2012 - 01/2004)
5.	Bader, Michael: 10 articles (12/2011 - 02/2002)
6.	Williams, Gordon H: 9 articles (10/2012 - 04/2002)
7.	Keefe, Deborah L: 9 articles (07/2011 - 03/2007)
8.	Sakoda, Mariyo: 9 articles (01/2011 - 05/2006)
9.	Danser, A H Jan: 8 articles (10/2012 - 02/2002)
10.	Sowers, James R: 8 articles (06/2012 - 02/2007)

Related Diseases

1.	Hypertension (High Blood Pressure) 11/01/1985 - "Hypertension was cured dramatically and plasma renin activity was within the normal range after the operation. " 11/01/1980 - "Patients with renin-dependent hypertension had dramatic reduction in blood pressure in most instances; 90% were cured or improved. " 12/01/1989 - "Clinical studies have proved their efficacy, safety, and good tolerability alone or in combination with other drugs in uncomplicated hypertension in which they are particularly effective in older, low renin, and possibly, black patients. " 01/01/1988 - "Clinical studies have proved their efficacy, safety, and good tolerability alone or in combination with other drugs in uncomplicated hypertension where they are particularly effective in older and low-renin and possibly black patients. " 10/01/1987 - "In this study, a significant reduction of u-cDA and of u-tDA was also found in those patients with low renin essential hypertension. " Order ALL the reference details at left...
2.	Heart Failure 02/01/1969 - "Hepatic clearance of renin in canine experimental models for low- and high-output heart failure." 04/01/2009 - "[Direct renin inhibition: a new and promising treatment principle in heart failure?]." 03/01/2010 - "Novel treatment strategy with direct renin inhibition against heart failure." 03/01/2010 - "Several ongoing clinical studies will probably clarify the role of renin inhibitors in heart failure. " 03/01/2000 - "About one third of heart failure patients in our study had low renin status and a non-activated RAAS, despite diuretic treatment. " Order ALL the reference details at left...
3.	Renal Artery Obstruction (Renal Artery Stenosis) 10/01/1994 - "However, the poor specificity was related to certain clinical characteristics; high baseline plasma renin activity measurements, female gender, current smoking, renal dysfunction, and bilateral renal artery stenosis were all associated with false-positive results. " 09/01/1989 - "In six of 10 patients with unilateral renal artery stenosis and in two patients with bilateral renal artery stenoses (two of 4 affected kidneys), the split renal function was improved after the therapeutic intervention, in accordance with the drop in blood pressure and the reduction of plasma renin activity. " 11/01/1999 - "The aim of this study was to determine the role of renal innervation in the prolonged stimulation of renin secretion and renin synthesis accompanying renal artery stenosis. " 04/01/1990 - "The distribution of renin-containing cells in kidneys with renal artery stenosis--an immunocytochemical study." 04/01/1989 - "All had lateralizing renal venous renin ratio (RVRR) studies, 15 had renal artery stenosis (RAS) on angiography and one had unilateral chronic parenchymal renal disease (CPRD). " Order ALL the reference details at left...
4.	Hyperaldosteronism (Conn Syndrome) 07/01/2000 - "The blood chemistry studies showed elevated levels of peripheral renin with evidence of secondary aldosteronism. " 08/01/1989 - "In the present study, the renal, hemodynamic, humoral, and vascular effects of a synthetic (WY-47663) human analogue were studied in five water-loaded (15 ml H2O/kg) patients with adenomatous primary aldosteronism, a salt-sensitive, low renin, volume-expanded syndrome. " 01/17/1989 - "The results of a peripheral renin-study were typical for secondary aldosteronism. " 09/28/1968 - "[Renin studies in idiopathic edemas with secondary hyperaldosteronism]." 01/01/1968 - "Studies on plasma renin activity in patients with primary aldosteronism." Order ALL the reference details at left...
5.	Neoplasms (Cancer) 01/01/2010 - "Imunohistochemistry of tumor was positive for CD34 and CD117 and this finding is effective in the diagnosis of JCT if immunostain for renin is unavailable. " 03/31/1976 - "When large amounts of big renin are secreted by a renal tumor, hyperfusion may ensue and be cured by removal of the tumor. " 06/01/1994 - "The discovery of a renin-secreting tumor therefore constitutes a life-saving diagnosis for the patient, a subject of reflection for the specialist, and a useful tool for studies of the general mechanisms involved in enzyme biosynthesis and tumoral endocrine cell function." 07/01/1993 - "Studies on cultured human renin(R)-producing tumors cells are few. " 06/01/1993 - "The juxtaglomerular cell tumor was pathologically confirmed and localization renin in the tumor cells was shown by immunohistochemical study. " Order ALL the reference details at left...

Related Drugs and Biologics

1.	Aldosterone
2.	Angiotensins
3.	Captopril (Capoten)
4.	Sodium
5.	aliskiren
6.	Angiotensin II
7.	Norepinephrine (Noradrenaline)
8.	Spironolactone (Aldactone)
9.	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)
10.	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)

Related Therapies and Procedures

1.	Nephrectomy
2.	Adrenalectomy
3.	Transplants (Transplant)
4.	Drug Therapy (Chemotherapy)
5.	Transplantation (Transplant Recipients)

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