Hypromellose Derivatives

Polymeric compounds that contain repeating units of hydroxypropyl methylcellulose. The properties of hypromellose polymers can vary greatly and are defined by their molecular weight, the percentage of hydroxyl groups, the percentage of hydroxypropyl groups, and viscosity measurements. They are found a broad variety of commercial products such as FOOD ADDITIVES; EXCIPIENTS; and LUBRICANTS.

Also Known As:

Networked: 160 relevant articles (12 outcomes, 37 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ito, Yoshimasa: 3 articles (01/2015 - 01/2010)
2.	Nagai, Noriaki: 3 articles (01/2015 - 01/2010)
3.	Yokoyama, Wallace: 3 articles (07/2013 - 09/2009)
4.	Young, Scott A: 3 articles (07/2013 - 06/2011)
5.	Alvarez, Vera A: 2 articles (10/2021 - 02/2019)
6.	Calvo, Natalia L: 2 articles (10/2021 - 02/2019)
7.	Lamas, María C: 2 articles (10/2021 - 02/2019)
8.	Leonardi, Darío: 2 articles (10/2021 - 02/2019)
9.	Quiroga, Ariel D: 2 articles (10/2021 - 02/2019)
10.	Svetaz, Laura A: 2 articles (10/2021 - 02/2019)

Related Diseases

1.	Dry Eye Syndromes (Dry Eye Syndrome) 02/01/2015 - "The aim of this study was to evaluate the effectiveness of punctal occlusion using hypromellose 2% in patients with dry eye. " 11/05/2021 - "Twenty rabbits were divided into 4 groups (n = 5, each group): healthy rabbits, dry eye rabbits, dry eye rabbits treated with hypromellose (HPMC), and dry eye rabbits treated with Artemia salina. " 02/01/2015 - "Our results suggest that punctal occlusion using hypromellose 2% is a low-cost and safe additional treatment for dry eye." 02/01/2015 - "Prospective evaluation of hypromellose 2% for punctal occlusion in patients with dry eye." 04/01/2014 - "Hypromellose drops caused an increase in total higher order aberrations (p=<0.01 in normal and dry eyes) and a reduction in Strehl ratio (normal eyes: p=<0.01, dry eyes p=0.01) immediately after instillation. "
2.	Cataract (Cataracts) 12/01/2017 - "This study aimed to investigate the protective effect of intraoperative used hydroxypropyl methylcellulose (HPMC 2%) on the ocular surface after cataract surgery. " 10/01/2011 - "Hydroxypropyl methylcellulose 2% provided significantly better optical clarity than BSS during cataract surgery. " 10/01/1993 - "It was concluded that there is a probable link between the intraocular use of hypromellose and abnormal pupils after cataract surgery." 10/01/1993 - "Hypromellose can be used as a viscoelastic substance during cataract surgery. " 10/01/1993 - "The fixed dilated pupil after cataract surgery--is it related to intraocular use of hypromellose?"
3.	Hemorrhage 11/16/2023 - "In this study, CS and hydroxypropylmethylcellulose (HPMC) were combined to develop a safe and effective hemostatic composite sponges (CS/HPMC) for hemorrhage control by a simple mixed-lyophilization strategy. " 05/01/2017 - "Modulation of microenvironmental pH for dual release and reduced in vivo gastrointestinal bleeding of aceclofenac using hydroxypropyl methylcellulose-based bilayered matrix tablet." 01/01/2020 - "The primary objective was to compare the efficacy of 12 weeks of daily treatment with Aqueous Hypromellose-based vaginal (Vagivital®) gel versus Aqueous Hypromellose-based vaginal gel plus 400 IU oxytocin gel in reducing the severity of the most bothersome vulvovaginal atrophy symptoms (MBS: itching, dysuria, bleeding, and pain/discomfort during vaginal sexual activity) observed at baseline. "
4.	Glaucoma 08/01/1987 - "For this reason use of hypromellose should be confined to situations where its use is likely to confer some special advantage, as in the presence of a bound-down pupil in patient's with chronic glaucoma or perhaps to facilitate "in the bag" implantation." 09/01/2017 - "The present study aimed to compare microbead injection with and without hydroxypropyl methylcellulose (HPM) in order to establish an experimental animal model of glaucoma. " 09/01/2017 - "Establishment of an experimental glaucoma animal model: A comparison of microbead injection with or without hydroxypropyl methylcellulose." 01/01/2023 - "Hydroxypropyl methylcellulose (HPMC) polymer was injected into the anterior chamber to experimental induce glaucoma. " 01/01/2015 - "In our work we (i) designed a rabbit model of chronic, moderately elevated IOP for studying glaucoma and (ii) demonstrated efficacy of mitochondria-targeted antioxidant SkQ1 as a tool to reverse several traits of experimental glaucoma induced by a series of injections of hydroxypropylmethylcellulose (HPMC) to the anterior chamber of the rabbit eye. "
5.	Pain (Aches) 01/01/2016 - "Cross-sectional study of 118 individuals reporting artificial tears use (hypromellose 0.4%) to treat dry eye-associated ocular pain. " 01/01/2018 - "The older study, using a contact lens no longer in common use, found an increased risk of pain and complications with the contact lens compared with hypromellose drops and paraffin ointment at night.A single-centre, Australian study, with 33 participants, provided low-certainty evidence of an increased risk of recurrence with phototherapeutic keratectomy compared with alcohol delamination but with wide confidence intervals, compatible with increased or decreased risk (RR 1.27, 95% CI 0.48 to 3.37). " 01/01/2022 - "The study aimed to fabricate and evaluate Meloxicam (MLX) loaded Hydroxypropyl Methylcellulose (HPMC) microparticles for colon targeting because MLX is a potent analgesic used in the treatment of pain and inflammation associated with colorectal cancer (CRC). " 01/01/2020 - "The primary objective was to compare the efficacy of 12 weeks of daily treatment with Aqueous Hypromellose-based vaginal (Vagivital®) gel versus Aqueous Hypromellose-based vaginal gel plus 400 IU oxytocin gel in reducing the severity of the most bothersome vulvovaginal atrophy symptoms (MBS: itching, dysuria, bleeding, and pain/discomfort during vaginal sexual activity) observed at baseline. "

Related Drugs and Biologics

1.	Hyaluronic Acid (Hyaluronan)
2.	Carboxymethylcellulose Sodium (Polycell)
3.	Hydrogels
4.	Ointments (Pastes)
5.	Vaginal Creams, Foams, and Jellies (Vaginal Tablet)
6.	Oxytocin (Pitocin)
7.	Isoflavones
8.	Hemostatics (Antihemorrhagics)
9.	Arginine (L-Arginine)
10.	Methylcellulose (BFL)

Related Therapies and Procedures

1.	Therapeutics
2.	Intraocular Lens Implantation
3.	Phacoemulsification
4.	Injections
5.	Chronotherapy