A preliminary investigation into the effects of ocular lubricants on higher order aberrations in normal and dry eye subjects.

Abstract

PURPOSE:

To study the effects of ocular lubricants on higher order aberrations in normal and self-diagnosed dry eyes.

METHODS:

Unpreserved hypromellose drops, Tears Again™ liposome spray and a combination of both were administered to the right eye of 24 normal and 24 dry eye subjects following classification according to a 5 point questionnaire. Total ocular higher order aberrations, coma, spherical aberration and Strehl ratios for higher order aberrations were measured using the Nidek OPD-Scan III (Nidek Technologies, Gamagori, Japan) at baseline, immediately after application and after 60 min. The aberration data were analyzed over a 5mm natural pupil using Zernike polynomials. Each intervention was assessed on a separate day and comfort levels were recorded before and after application. Corneal staining was assessed and product preference recorded after the final measurement for each intervention.

RESULTS:

Hypromellose drops caused an increase in total higher order aberrations (p=<0.01 in normal and dry eyes) and a reduction in Strehl ratio (normal eyes: p=<0.01, dry eyes p=0.01) immediately after instillation. There were no significant differences between normal and self-diagnosed dry eyes for response to intervention and no improvement in visual quality or reduction in higher order aberrations after 60 min. Differences in comfort levels failed to reach statistical significance.

CONCLUSION:

Combining treatments does not offer any benefit over individual treatments in self-diagnosed dry eyes and no individual intervention reached statistical significance. Symptomatic subjects with dry eye and no corneal staining reported an improvement in comfort after using lubricants.

• Authors: Samantha McGinnigle, Frank Eperjesi, Shehzad A Naroo
• Journal: Contact lens & anterior eye : the journal of the British Contact Lens Association (Cont Lens Anterior Eye) Vol. 37 Issue 2 Pg. 106-10 (Apr 2014) ISSN: 1476-5411 [Electronic] England
• PMID: 24075240 (Publication Type: Journal Article, Randomized Controlled Trial)
• Copyright: Copyright © 2013 British Contact Lens Association. Published by Elsevier Ltd. All rights reserved.

Chemical References

• Lubricants
• Ophthalmic Solutions
• Wetting Agents

Topics

• Dry Eye Syndromes (complications, diagnosis, drug therapy)
• Female
• Humans
• Lubricants (administration & dosage)
• Male
• Ophthalmic Solutions (administration & dosage)
• Pilot Projects
• Reference Values
• Refractive Errors (diagnosis, drug therapy, etiology)
• Treatment Outcome
• Wetting Agents (administration & dosage)
• Young Adult