Abstract | BACKGROUD: METHODS: A total of 149 eyes (149 patients) diagnosed with age-related cataract, age 69.19 ± 9.74 years, were enrolled in this prospective, parallel-design, continuous, randomised controlled study. Patients were randomly assigned to receive HPMC 2% (study group) or balanced salt solution (control group) during the surgery to moisturize the cornea surface. The Ocular Surface Disease Index, Schirmer test without topical anesthetics, tear break-up time, and corneal fluorescein staining were assessed preoperatively, 1 day, 1 week, and 1 month after the surgery, respectively. RESULTS: The Schirmer test value of male patients in the study group at 1 week postoperation was higher than that of male patients in the control group (P = .019). For patients diagnosed with dry eye before the surgery, Schirmer test value in the male patients in the study group at 1 month after surgery was higher than that in the male patients in the control group (P = .037). Furthermore, for the cluster of preoperative dry eye patients whose surgical time was longer than median, corneal fluorescein staining of the patients in the study group was superior to that of the patients in the control group (P = .032). CONCLUSION: Intraoperative use of HPMC 2% on the cornea surface could improve clinical outcomes of tear film and ocular surface health to some degree, especially in the patients diagnosed with dry eye before the surgery, male patients, and patients whose surgical time was relatively longer.
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Authors | Yuan He, Jia Li, Jingfen Zhu, Ying Jie, Ningli Wang, Jun Wang |
Journal | Medicine
(Medicine (Baltimore))
Vol. 96
Issue 50
Pg. e8940
(Dec 2017)
ISSN: 1536-5964 [Electronic] United States |
PMID | 29390284
(Publication Type: Journal Article, Randomized Controlled Trial)
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Copyright | Copyright © 2017 The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved. |
Chemical References |
- Ophthalmic Solutions
- Hypromellose Derivatives
|
Topics |
- Aged
- Cataract Extraction
(methods)
- Cornea
- Dry Eye Syndromes
(etiology, prevention & control)
- Female
- Humans
- Hypromellose Derivatives
(therapeutic use)
- Intraoperative Care
- Male
- Ophthalmic Solutions
(therapeutic use)
- Prospective Studies
- Treatment Outcome
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