alpha7 Nicotinic Acetylcholine Receptor

A member of the NICOTINIC ACETYLCHOLINE RECEPTOR subfamily of the LIGAND-GATED ION CHANNEL family. It consists entirely of pentameric α7 subunits expressed in the CNS, autonomic nervous system, vascular system, lymphocytes and spleen.

Also Known As:

Nicotinic Acetylcholine Receptor alpha7; Receptor, alpha-Bungarotoxin; alpha-Bungarotoxin Receptors; alpha7nAChR; nAChR alpha7 Subunit; Receptor, alpha Bungarotoxin; Receptors, alpha-Bungarotoxin; Subunit, nAChR alpha7; alpha Bungarotoxin Receptors; alpha-Bungarotoxin Receptor; alpha7 Subunit, nAChR

Networked: 167 relevant articles (6 outcomes, 21 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - Membrane Transport Proteins: 589
      - Ion Channels: 6731
        Ligand-Gated Ion Channels: 221
        Cysteine Loop Ligand-Gated Ion Channel Receptors: 14
        Nicotinic Receptors: 3452
        alpha7 Nicotinic Acetylcholine Receptor: 167
        mouse Chrna7 protein: 4
        Drosophila nAChRalpha3 protein
        human Chrna7 protein
        rat Chrna7 protein
        zebrafish chrna7 protein
  - Membrane Proteins: 10078

Experts

1.	Ulloa, Luis: 6 articles (01/2010 - 01/2003)
2.	Deutsch, Stephen I: 4 articles (08/2013 - 09/2003)
3.	Rosse, Richard B: 4 articles (08/2013 - 09/2003)
4.	Comery, Thomas A: 4 articles (12/2011 - 03/2009)
5.	Dunlop, John: 4 articles (12/2011 - 03/2009)
6.	Roncarati, Renza: 4 articles (12/2011 - 03/2009)
7.	Gopalakrishnan, Murali: 4 articles (09/2010 - 09/2007)
8.	Al-Abed, Yousef: 4 articles (08/2010 - 01/2003)
9.	de Jonge, Wouter J: 4 articles (05/2010 - 10/2007)
10.	Freedman, Robert: 4 articles (04/2009 - 12/2002)

Related Diseases

1.	Schizophrenia (Dementia Praecox) 07/21/2009 - "Since rat and mouse models are widely used for studies of specific abnormalities in schizophrenia, we sought to determine the subcellular location of the alpha7nAChR with respect to VAChT storage vesicles in axon terminals in the PFC in both species. " 10/01/2003 - "Recent studies have suggested that the alpha7 nicotinic acetylcholine receptor (alpha7 AChR) may play a role in the pathogenesis of schizophrenia. " 01/01/2017 - "Alpha7 nicotinic acetylcholine receptor (α7 nAChR) dysfunction plays an important role in schizophrenia. " 01/01/2016 - "Alpha7 nicotinic acetylcholine receptor agonists and PAMs as adjunctive treatment in schizophrenia. " 04/01/2009 - "Association of the 5'-upstream regulatory region of the alpha7 nicotinic acetylcholine receptor subunit gene (CHRNA7) with schizophrenia."
2.	Alzheimer Disease (Alzheimer's Disease) 01/04/2022 - "BACKGROUND To reveal the mechanism underlying the effect of alpha7 nicotinic acetylcholine receptor (nAChR) on neurodegeneration in Alzheimer disease (AD), the influence of the receptor on recognition in APP/PS1 mice was evaluated by using its selective agonist (PNU-282987). " 02/01/2013 - "Virtual screening for alpha7 nicotinic acetylcholine receptor for treatment of Alzheimer's disease." 10/15/2011 - "Research update: Alpha7 nicotinic acetylcholine receptor mechanisms in Alzheimer's disease." 09/01/2010 - "We previously reported that alpha7 nicotinic acetylcholine receptor (nAChR) agonism produces efficacy in preclinical cognition models correlating with activation of cognitive and neuroprotective signaling pathways associated with Alzheimer's disease (AD) pathology. " 05/01/2009 - "Possible drug candidates for Alzheimer's disease deduced from studying their binding interactions with alpha7 nicotinic acetylcholine receptor."
3.	Inflammation (Inflammations) 12/01/2021 - "Our previous study found SIN inhibited inflammation via alpha7 nicotinic acetylcholine receptor (α7nAChR) in macrophages in vitro. " 04/01/2011 - "Recent studies have shown that nicotinic acetylcholine receptor alpha7 subunit (nAChRα7) plays an important role in regulation of inflammation, angiogenesis and keratinocyte biology, but little is known about its expression after the skin is wounded. " 04/01/2016 - "In this respect, selective alpha7 nicotinic acetylcholine receptor (α7nAChR) agonists have shown anti-inflammatory properties in several animal models of inflammation. " 06/08/2012 - "The role of the alpha7 nicotinic acetylcholine receptor (α7nAChR) in inflammation has recently been identified. " 08/01/2009 - "Moreover, alpha7nAChR has been shown important for immune regulation also in the absence of nerves, but little is known about these mechanisms in chronic joint inflammation. "
4.	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 10/01/2019 - "Alpha7 Nicotinic Acetylcholine Receptor Alleviates Inflammatory Bowel Disease Through Induction of AMPK-mTOR-p70S6K-Mediated Autophagy." 12/14/2006 - "Studies using the alpha7nAChR agonist, nicotine, for the treatment of mucosal inflammation have been undertaken but the efficacy of nicotine as a treatment for inflammatory bowel diseases remains debatable. "
5.	Sepsis (Septicemia) 01/01/2010 - "Although activation of the alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) modulates the response to sepsis, the role of this pathway in the development of sepsis-induced acute lung injury (ALI) is not known. " 06/01/2011 - "Activation of nicotinic acetylcholine receptor alpha7 subunit (α7nAChR) by nicotine leads to the improved survival rate in experimental model of sepsis. " 01/01/2010 - "Requisite role of the cholinergic alpha7 nicotinic acetylcholine receptor pathway in suppressing Gram-negative sepsis-induced acute lung inflammatory injury." 12/01/2007 - "Pharmacologic alpha7nAChR agonists inhibit production of the critical proinflammatory mediator high mobility group box 1 (HMGB1) and rescue mice from lethal polymicrobial sepsis. " 09/01/2008 - "Here, we studied the anti-inflammatory potential of choline in murine endotoxemia and sepsis, and the role of the alpha7nAChR in mediating the suppressive effect of choline on TNF release. "

Related Drugs and Biologics

1.	Nicotine
2.	3-(2,4-dimethoxybenzylidene)anabaseine
3.	Amyloid (Amyloid Fibrils)
4.	Amyloid Precursor Protein Secretases (beta-Secretase)
5.	alpha7 Nicotinic Acetylcholine Receptor
6.	Cholinergic Agents (Cholinergics)
7.	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)
8.	amyloid beta-protein (1-42)
9.	Cytokines
10.	Cholinergic Receptors

Related Therapies and Procedures

1.	Self Administration (Administration, Self)
2.	Vagus Nerve Stimulation
3.	Therapeutics