Member 3 Solute Carrier Family 12

Na-Cl cotransporter in the convoluted segments of the DISTAL KIDNEY TUBULE. It mediates active reabsorption of sodium and chloride and is inhibited by THIAZIDE DIURETICS.

Also Known As:

Solute Carrier Family 12, Member 3; NCCT Protein; Na-Cl Cotransporter; Na-Cl Symporter; Na-Cl Thiazide-Sensitive Cotransporter; SLC12A3 Cotransporter; SLC12A3 Protein; Thiazide-Sensitive Sodium-Chloride Cotransporter; Cotransporter, Na-Cl; Cotransporter, Na-Cl Thiazide-Sensitive; Cotransporter, SLC12A3; Cotransporter, Thiazide-Sensitive Sodium-Chloride; Na Cl Cotransporter; Na Cl Symporter; Na Cl Thiazide Sensitive Cotransporter; Protein, NCCT; Protein, SLC12A3; Sodium-Chloride Cotransporter, Thiazide-Sensitive; Symporter, Na-Cl; Thiazide Sensitive Sodium Chloride Cotransporter; Thiazide-Sensitive Cotransporter, Na-Cl

Networked: 134 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Gamba, Gerardo: 7 articles (01/2018 - 01/2003)
2.	Hadchouel, Juliette: 7 articles (01/2018 - 10/2010)
3.	Uchida, Shinichi: 6 articles (01/2019 - 01/2013)
4.	Jeunemaitre, Xavier: 5 articles (01/2019 - 10/2010)
5.	Loffing, Johannes: 5 articles (01/2018 - 06/2005)
6.	Lin, Shih-Hua: 5 articles (01/2015 - 02/2004)
7.	Vargas-Poussou, Rosa: 4 articles (01/2022 - 03/2012)
8.	Ellison, David H: 4 articles (01/2018 - 11/2014)
9.	Vázquez, Norma: 4 articles (01/2018 - 11/2014)
10.	Fujita, Toshiro: 4 articles (01/2017 - 05/2011)

Related Diseases

1.	Hypertension (High Blood Pressure) 10/19/2010 - "Even though the increase in NCC activity in KS-WNK1(-/-) mice was less pronounced than in mice overexpressing a mutant form of WNK4, our study suggests that the activation of Na-Cl cotransporter is not sufficient by itself to induce a hyperkalemic hypertension and that the deregulation of other channels, such as the Epithelial Na(+) channel (ENaC), is probably required." 01/01/2022 - "The recent description of familial hyperkalaemic hypertension (FHHt)-causative mutations affecting the acidic domain of WNK1 supports the notion that KS-WNK1 activates the Na+:Cl- cotransporter NCC. " 11/15/2015 - "Increased phosphorylation of the renal Na+-Cl- cotransporter in male kidney transplant recipient patients with hypertension: a prospective cohort." 11/01/2015 - "Increased Na(+) reabsorption through Na(+)-Cl(-) cotransporter (NCC) in the distal convoluted tubule plays an important role in the pathogenesis of hypertension in patients with PHA2. " 11/01/2014 - "Their mutations lead to familial hyperkalemic hypertension (FHHt), associated with an activation of the Na-Cl cotransporter (NCC). "
2.	Diabetic Nephropathies (Diabetic Nephropathy) 11/01/2003 - "Genotyping of these patients at >55,000 SNP loci indicated a gene encoding solute carrier family 12 member 3 (SLC12A3) to be a good candidate for the susceptibility to diabetic nephropathy, in view of a significant association of one landmark SNP located in the 24th intron (chi(2) = 15.4, P = 0.000087, odds ratio = 2.53 [95% CI 1.57-4.09]). " 01/01/2022 - "SLC12A3 (solute carrier family 12 member 3) gene variants are associated with diabetic nephropathy; however, their association with hypertensive nephropathy remains unknown. " 03/01/2006 - "Previous studies have revealed that polymorphisms in the SLC12A3 (solute carrier family 12 member [sodium/chloride] 3) gene, which encodes solute carrier family 12 member 3, might contribute to genetic susceptibility to diabetic nephropathy and essential hypertension. "
3.	Genetic Predisposition to Disease (Genetic Predisposition) 03/01/2006 - "Previous studies have revealed that polymorphisms in the SLC12A3 (solute carrier family 12 member [sodium/chloride] 3) gene, which encodes solute carrier family 12 member 3, might contribute to genetic susceptibility to diabetic nephropathy and essential hypertension. "
4.	Essential Hypertension 03/01/2006 - "Previous studies have revealed that polymorphisms in the SLC12A3 (solute carrier family 12 member [sodium/chloride] 3) gene, which encodes solute carrier family 12 member 3, might contribute to genetic susceptibility to diabetic nephropathy and essential hypertension. "
5.	Gitelman Syndrome 11/01/2023 - "Gitelman syndrome (GS) is an autosomal recessive tubulopathy resulting from inactivating mutations in the SLC12A3 gene that encodes the thiazide-sensitive sodium-chloride cotransporter (NCC). " 01/01/2023 - "Genetic testing revealed compound heterozygous mutations in the SLC12A3 gene (c.506-1G > A, c.1456G > A) encoding the thiazide-sensitive sodium-chloride cotransporter, which presented a definitive diagnosis of Gitelman syndrome (GS). " 12/01/2022 - "The dysfunction of Na+-Cl- cotransporter (NCC) caused by mutations in solute carrier family12, member 3 gene (SLC12A3) primarily causes Gitelman syndrome (GS). " 10/01/2022 - "Gitelman syndrome (GS) is the disease model of the inactivation of thiazide-sensitive sodium chloride cotransporter (NCC), which is believed to benefit bone mass and reduce fracture risk. " 01/01/2022 - "Gitelman syndrome is caused by biallelic pathogenic variants in SLC12A3, encoding the Na+-Cl- cotransporter (NCC) expressed in the distal convoluted tubule. "

Related Drugs and Biologics

1.	Salts
2.	Sodium Chloride Symporter Inhibitors (Diuretics, Thiazide)
3.	Thiazides
4.	Symporters
5.	Sodium Chloride
6.	Messenger RNA (mRNA)
7.	Solute Carrier Family 12
8.	Phosphotransferases (Kinase)
9.	Sodium
10.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Transplantation