Alice in Wonderland Syndrome

Neurological condition characterized by disturbances in VISUAL PERCEPTION, most often of BODY SCHEMA, TIME PERCEPTION and HALLUCINATIONS. It is associated with MIGRAINE, infections (e.g., INFECTIOUS MONONUCLEOSIS), FEVER, EPILEPSY, and other neurological and psychiatric disorders.

Networked: 17 relevant articles (0 outcomes, 1 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Migraine Disorders (Migraine)
2.	Epilepsy (Aura)
3.	Infectious Mononucleosis (Glandular Fever)
4.	Illusions (Auditory Illusions)
5.	Headache (Headaches)

Experts

1.	Bidgoli, Sina: 1 article (12/2020)
2.	Dugauquier, Artémise: 1 article (12/2020)
3.	Duarte, Augusto: 1 article (08/2020)
4.	Fernandes, Diana: 1 article (08/2020)
5.	Maio, Cláudia: 1 article (08/2020)
6.	Salazar, Tatiana: 1 article (08/2020)
7.	Vilela, Maria: 1 article (08/2020)
8.	Nielsen, Jens Erik Klint: 1 article (07/2019)
9.	Rasmussen, Pernille Darling: 1 article (07/2019)
10.	Vilmar, Janne Walløe: 1 article (07/2019)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Alice in Wonderland Syndrome:

1.	Hallucinogens (Psychedelics)IBA 11/01/1999 - "Visual illusions characterized by distortion of form, size, reciprocal position of objects, movement, or color, labeled as "Alice in Wonderland" syndrome, were discussed in children with infectious mononucleosis, as well as in other clinical conditions, such as migraine, epilepsy, use of certain hallucinogenic drugs, etc. The purpose of our study was to investigate for the first time visual evoked potential results in children with "Alice in Wonderland" syndrome associated with infectious mononucleosis. " 01/01/2015 - "LSD-associated "Alice in Wonderland Syndrome"(AIWS): A Hallucinogen Persisting Perception Disorder (HPPD) Case Report."
2.	Methylphenidate (Ritalin)FDA LinkGeneric 12/09/2020 - "Methylphenidate-associated Alice in Wonderland syndrome." 01/01/2023 - "Alice in Wonderland Syndrome as a potential side-effect in Attention Deficit Hyperactivity Disorder patients undergoing Methylphenidate treatment." 12/09/2020 - "We describe the case of a child affected by typical symptoms of Alice in Wonderland syndrome (AIWS), related to the methylphenidate treatment he was taking for an attention deficit hyperactivity disorder (ADHD). "
3.	Topiramate (Topamax)FDA LinkGeneric 02/01/2011 - "Here, the case of a 17-year-old girl with migraine without aura who developed an 'Alice in Wonderland' syndrome repeatedly on topiramate treatment was presented and potential pathophysiological concepts were discussed." 02/01/2011 - ""Alice in Wonderland syndrome" associated with topiramate for migraine prevention." 05/01/2006 - "Topiramate use may cause palinopsia and may be associated with the Alice in Wonderland syndrome through an unknown mechanism." 05/01/2006 - "A third patient is described who developed the "Alice in Wonderland" syndrome about 1 week after starting topiramate for migraine prevention with complete resolution of symptoms about 1 month after stopping. " 05/01/2006 - "Reversible palinopsia and the Alice in Wonderland syndrome associated with topiramate use in migraineurs."
4.	Sertraline (Zoloft)FDA LinkGeneric 08/30/2020 - "When Alice Took Sertraline: A Case of Sertraline-Induced Alice in Wonderland Syndrome."
5.	Technetium Tc 99m Exametazime (Ceretec)FDA Link 01/01/2018 - "Aripiprazole-Triggered Alice in Wonderland Syndrome Episodes Studied with 99mTc-HMPAO Brain SPECT."
6.	Retinaldehyde (Retinal)IBA 02/01/2016 - "In this article, we review the literature on hemiplegic migraines, alternating hemiplegia of childhood, migraine with brainstem aura, retinal migraine, ophthalmoplegic migraine, Alice in Wonderland syndrome, and acute confusional migraine. "
7.	Lysergic Acid Diethylamide (LSD)IBA 01/01/2015 - "Here we present the case of a patient with a previous history of sporadic and recreational cannabis, alcohol and LSD consumption who reported LSD associated "Alice in Wonderland Syndrome" (AIWS) or Todd's syndrome. " 01/01/2015 - "LSD-associated "Alice in Wonderland Syndrome"(AIWS): A Hallucinogen Persisting Perception Disorder (HPPD) Case Report."
8.	Butylated Hydroxyanisole (BHA)IBA 01/01/2019 - "In this work, we describe an association of brainstem headache with aura (BHA) and Alice in Wonderland syndrome (AIWS) in a 17-year-old male, suffering from crises of vertigo, weakness, dysarthria, and diplopia, in half-hour duration, followed by diffuse or occipital headache, lasting several hours. "
9.	Anti-Bacterial Agents (Antibiotics)IBA 03/01/2012 - "This case report is the first, to our knowledge, of neuroborreliosis presenting as Alice in Wonderland syndrome with complete resolution of findings after intravenous antibiotic treatment."
10.	Lamotrigine (Lamictal)FDA LinkGeneric 07/08/2019 - "A diagnosis of Alice in Wonderland syndrome (AIWS) presumably associated to migraine was made, and the girl was successfully treated with lamotrigine. "

Therapies and Procedures

1.	Telescopes 01/01/2019 - "A literature review was completed in PubMed using the following terms paired with "migraine" and "headache:" dry eye, eye pain, monocular diplopia, binocular diplopia, photophobia, visual field defect, tunnel vision, floaters, amaurosis fugax, transient visual obscuration, autonomic symptoms, anisocoria, visual snow, Alice in Wonderland syndrome, and palinopsia. "
2.	Transcranial Magnetic Stimulation 01/01/2011 - "Treatment of Alice in Wonderland syndrome and verbal auditory hallucinations using repetitive transcranial magnetic stimulation: a case report with fMRI findings."
3.	Surgical Amputation (Amputations) 06/01/2017 - "The first part of the article describes unilateral disorders of the bodily self, such as asomatognosia, feelings of amputation, supernumerary phantom limbs and somatoparaphrenia, as well as descriptions of non-lateralized disorders of the bodily self, including Alice in Wonderland syndrome and autoscopic hallucinations. "
4.	Endurance Training 01/01/2023 - "Stabilization of the cervical spine through flexor endurance training for Alice in Wonderland syndrome presenting as an aura of migraine- A case report."