Uroplakin Ib

A tetraspanin domain-containing uroplakin subtype. It heterodimerizes with UROPLAKIN III to form a component of the asymmetric unit membrane found in urothelial cells.

Also Known As:

Networked: 9 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Jackson, Paul: 2 articles (12/2005 - 03/2004)
2.	Leonardos, Lefta: 2 articles (12/2005 - 03/2004)
3.	Gu, Menghui: 1 article (12/2020)
4.	Gu, Xinhua: 1 article (12/2020)
5.	Jiang, Yannan: 1 article (12/2020)
6.	Shen, Renbin: 1 article (12/2020)
7.	Xu, Wei: 1 article (12/2020)
8.	Yuan, Zhen: 1 article (12/2020)
9.	Zhang, Yan: 1 article (12/2020)
10.	Chen, Borong: 1 article (07/2020)

Related Diseases

1.	Transitional Cell Carcinoma 06/07/2002 - "The uroplakin Ib (UPIb) gene is predominantly expressed in urothelium and is overexpressed in 50% of transitional cell carcinoma (TCC). " 12/01/2005 - "Levels of uroplakin Ib mRNA are dramatically reduced or absent in many transitional cell carcinomas, but the molecular mechanisms responsible remain undetermined. " 03/01/2004 - "Expression of uroplakin Ib mRNA is reduced or absent in many transitional cell carcinomas (TCCs) but molecular mechanisms underlying loss of expression remain to be determined. " 09/01/1998 - "Expression of uroplakin Ib and uroplakin III genes in tissues and peripheral blood of patients with transitional cell carcinoma."
2.	Neoplasms (Cancer) 12/01/2005 - "Uroplakin Ib gene transcription in urothelial tumor cells is regulated by CpG methylation." 07/01/2020 - "Furthermore, the expression of collagen triple helix repeat containing 1 (CTHRC1), serpin family E member 1 (SERPINE1), Versican (VCAN) was associated with tumor size, Uroplakin 1B (UPK1B) expression was associated with distant metastasis. " 12/01/2020 - "A total of 30 differentially expressed genes (DEGs) were identified using the gene expression profiles from The Cancer Genome Atlas capecitabine and oxaliplatin treatment GC cases and seven key DEGs [uroplakin-1b (UPK1B), fatty acid-binding protein, heart (FABP3), cystatin-M, caspase-5 (CASP5), corticosteroid 11-β-dehydrogenase isozyme 2, cytochrome P450 4X1 (CYP4X1) and epidermal growth factor receptor kinase substrate 8-like protein 3] were associated with survival. "
3.	Carcinoma (Carcinomatosis) 03/01/2004 - "Methylation of a CpG island within the uroplakin Ib promoter: a possible mechanism for loss of uroplakin Ib expression in bladder carcinoma." 03/01/2004 - "A trend between uroplakin Ib mRNA expression and CpG methylation was also observed in normal urothelium and bladder carcinomas. " 02/09/1999 - "Cloning of the human uroplakin 1B cDNA and analysis of its expression in urothelial-tumor cell lines and bladder-carcinoma tissue."
4.	Urinary Tract Infections (Urinary Tract Infection) 10/01/2011 - "To evaluate genetic variations of innate immune system such as mannose binding lectin (MBL), Toll like receptor 4 (TLR4), CD14, LY96 (MD2) and Uroplakin 1B (UPK1B) genes in children with recurrent urinary tract infection (UTI). "
5.	Neoplasm Metastasis (Metastasis) 07/01/2020 - "Furthermore, the expression of collagen triple helix repeat containing 1 (CTHRC1), serpin family E member 1 (SERPINE1), Versican (VCAN) was associated with tumor size, Uroplakin 1B (UPK1B) expression was associated with distant metastasis. "

Related Drugs and Biologics

1.	Messenger RNA (mRNA)
2.	ErbB Receptors (EGF Receptor)
3.	Uroplakin III
4.	Cystatin M
5.	Versicans (Versican)
6.	Toll-Like Receptor 4
7.	Fatty Acid-Binding Proteins
8.	Mannose-Binding Lectin (Mannan-Binding Lectin)
9.	Complementary DNA (cDNA)
10.	Serpins