HLA-B52 Antigen

A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*52 allele family.

Also Known As:

HLA Class I Histocompatibility Antigen, B-52 alpha Chain; HLA-B52; Antigen, HLA B52; Antigen, HLA-B52; B52 Antigen, HLA; HLA Class I Histocompatibility Antigen, B 52 alpha Chain; HLA B52 Antigen

Networked: 22 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Akashi, Koichi: 1 article (01/2021)
2.	Arinobu, Yojiro: 1 article (01/2021)
3.	Ayano, Masahiro: 1 article (01/2021)
4.	Horiuchi, Takahiko: 1 article (01/2021)
5.	Kimoto, Yasutaka: 1 article (01/2021)
6.	Kushimoto, Kazuo: 1 article (01/2021)
7.	Mitoma, Hiroki: 1 article (01/2021)
8.	Nakano, Miki: 1 article (01/2021)
9.	Niiro, Hiroaki: 1 article (01/2021)
10.	Nishimura, Keisuke: 1 article (01/2021)

Related Diseases

1.	Tuberculosis (Tuberculoses) 11/01/2006 - "Studies on HLA-B51 and HLA-B52 in a larger population to assess their role in tuberculosis may be useful for TB-vaccination strategies, since HLA profiles are likely to be related to vaccine efficacy." 11/01/1998 - "Several epitopes were also recognized in Tanzanians and cytotoxic T-lymphocytes recognized endogenously processed antigen.4. In tuberculosis patients with HLA-B52, a CD8+ cytotoxic T-lymphocyte epitope was identified in ESAT-6, a secreted antigen specific for M. "
2.	Neoplasms (Cancer) 05/01/1999 - "HLA-B52 restriction of the third CTL line was confirmed by the transfection of HLA-B5201 cDNA into the tumor cells. " 11/01/2003 - "Therefore, this TRG-derived peptide might be appropriate for use in peptide-based immunotherapy for relatively large numbers of cancer patients throughout the world, given that 34% of Japanese, 27% of Chinese, and 13% of Caucasians express either HLA-B52 or HLA-B62 molecules" 11/01/2003 - "In this study we report a unique cancer antigen gene, tentatively named Testin-related gene (TRG), which encodes CTL-directed epitopes on the HLA-B52 molecules most frequently expressed in Asians. "
3.	Takayasu Arteritis (Arteritis, Takayasu's) 01/01/2016 - "The Severity of Takayasu Arteritis Is Associated with the HLA-B52 Allele in Japanese Patients." 08/01/1996 - "By serologic HLA typing, positive associations of Takayasu's arteritis with HLA-B52 and B39 were observed. " 07/01/2001 - "These data confirm HLA-B52 as a relevant susceptibility allele for Takayasu's arteritis and suggest that HLA-B15 could be important as a marker of the disease in Mexican patients. " 10/01/1998 - "It was found that MICA-1.2 gave a significantly high OR of risk to Takayasu's arteritis in the absence of HLA-B52, suggesting that the HLA-linked gene susceptible to Takayasu's arteritis is mapped near the MICA gene. " 08/01/1993 - "Because two HLA-B alleles, HLA-B51 and B39.1, which are similar but different at the epitope from HLA-B52 and B39.2, respectively, are not associated with Takayasu arteritis, 63Glu and 67Ser are supposed to be involved in the pathogenesis."
4.	Aortic Valve Insufficiency (Aortic Regurgitation) 11/10/1995 - "Cine MRI demonstrated aortic regurgitation in 20 patients (48%), all of whom showed dilated ascending aorta; furthermore, 14 (70%) of them were confirmed as carrying HLA-B52. " 09/01/2020 - "Early detachment of prosthetic aortic valve one year after replacement for severe aortic regurgitation due to perforated aortic valve aneurysm; a case of suspected HLA-B52 positive Behçet's disease." 10/01/1998 - "In HLA-B52 positive TA patients, aortic regurgitation (vs B52(-)-B39(+), OR=3.8, P<0.05, vs B52(-)-B39(-), OR=5.49, P<0.001), ischemic heart disease (vs B52(-)-B39(+), OR=12.05, P<0.05, vs B52(-)-B39(-), OR=2.85, P<0.05), and pulmonary infarction (vs B52(-)-B39(+), OR=5.74, P<0.03) were found to be significantly prevalent. " 10/01/1998 - "Association of HLA-B52 and B39 with seven clinical manifestations--pulmonary infarction, ischemic heart disease, aortic regurgitation, systemic hypertension, renal artery stenosis, cerebrovascular disease, and visual disturbance--in 132 HLA-typed patients with Takayasu arteritis was studied. "
5.	Pulmonary Infarction 10/01/1998 - "In HLA-B52 positive TA patients, aortic regurgitation (vs B52(-)-B39(+), OR=3.8, P<0.05, vs B52(-)-B39(-), OR=5.49, P<0.001), ischemic heart disease (vs B52(-)-B39(+), OR=12.05, P<0.05, vs B52(-)-B39(-), OR=2.85, P<0.05), and pulmonary infarction (vs B52(-)-B39(+), OR=5.74, P<0.03) were found to be significantly prevalent. " 10/01/1998 - "Association of HLA-B52 and B39 with seven clinical manifestations--pulmonary infarction, ischemic heart disease, aortic regurgitation, systemic hypertension, renal artery stenosis, cerebrovascular disease, and visual disturbance--in 132 HLA-typed patients with Takayasu arteritis was studied. "

Related Drugs and Biologics

1.	HLA-B51 Antigen
2.	Antigens
3.	Epitopes
4.	Vaccines
5.	HLA-B15 Antigen
6.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
7.	Peptides (Polypeptides)
8.	HLA-B44 Antigen
9.	HLA-B14 Antigen
10.	HLA-B13 Antigen

Related Therapies and Procedures

1.	Bone Marrow Transplantation (Transplantation, Bone Marrow)
2.	Immunotherapy
3.	Drug Therapy (Chemotherapy)