HLA-B39 Antigen

A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*39 allele family.

Also Known As:

HLA B39; HLA Class I Histocompatibility Antigen, B-39 alpha Chain; HLA-B39; Antigen, HLA-B39; HLA B39 Antigen; HLA Class I Histocompatibility Antigen, B 39 alpha Chain

Networked: 16 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Bigoloni, Alba: 1 article (01/2022)
2.	Castagna, Antonella: 1 article (01/2022)
3.	Cernuschi, Massimo: 1 article (01/2022)
4.	Galli, Andrea: 1 article (01/2022)
5.	Galli, Laura: 1 article (01/2022)
6.	Guffanti, Monica: 1 article (01/2022)
7.	Muccini, Camilla: 1 article (01/2022)
8.	Poli, Andrea: 1 article (01/2022)
9.	Racca, Sara: 1 article (01/2022)
10.	Spagnuolo, Vincenzo: 1 article (01/2022)

Related Diseases

1.	Spondylarthropathies 01/01/1999 - "Previous studies indicated the increase of HLA-B39 among HLA-B27 negative patients with spondylarthropathies (SpA). " 07/01/2000 - "Other studies have revealed significant peptide-binding similarities between HLA-B27 and subtypes of HLA-B39, supporting a role of this antigen in spondyloarthropathy. " 11/01/1995 - "Because HLA-B27 and HLA-B39 share Glu at position 45 and Cys at position 67, both of which constitute components of the peptide-anchoring B pocket, and because they possess similar peptide-ligand motifs, our results may support either the role of the peptides presented by class I antigens or the importance of Cys at position 67, in the development of spondylarthropathies and pauciarticular-onset JRA."
2.	Axial Spondyloarthritis 11/01/2023 - "Our study also confirmed some of the results of previously conducted studies on predominant genes of HLA typing in axSpA: HLA-B27 in AS, HLA-B39 and HLA-Cw6 in r-axPsA, and HLA-Cw7 in nr-axPsA. "
3.	Disease Progression 06/01/1995 - "Univariate analysis revealed that the HLA antigens B27, B39, and DQw3 were associated with disease progression, while HLA-DR7 was "protective." The best multivariate model identified the HLA antigens B27, when DR7 was present, and DQw3, when DR7 was not present, as predicting disease progression across all transitions, while HLA-B39 was associated with progression in early disease. " 04/01/1998 - "Only HLA-B22 was added to the original model, which includes HLA-B39, providing risk for progression in early stages, HLA-B27 in the presence of HLA-DR7 providing risk for progression through all states, and DQw3 providing increased risk in the absence of DR7, while in the presence of DR7 it provides "protection." HLA-B22 provides protection from disease progression through all states. "
4.	Infections 01/01/2022 - "In patients with HIV-1 infection who maintained a good virological and immunological profile, HLA-B39 and -B55 may be associated with lower levels of HIV-1 DNA." 01/01/2004 - "HLA-DR4 and HLA-B39 could be associated directly with the infection by T. "
5.	Psoriatic Arthritis 01/01/1987 - "The hypothesis is formulated that HLA-B39 may discriminate a genetic subset of psoriatic arthritis characterized by a particular susceptibility to develop axial involvement." 01/01/1987 - "HLA-B39 and the axial type of psoriatic arthritis." 01/01/1987 - "The frequency distribution of HLA-B38 and HLA-B39 was studied in a group of 50 unrelated psoriatic arthritis patients. "

Related Drugs and Biologics

1.	HLA-B27 Antigen (HLA B27 Antigen)
2.	Peptides (Polypeptides)
3.	Antigens
4.	HLA-C*06 antigen
5.	HLA-C*70 antigen
6.	HLA-DR7 Antigen (HLA DR7 Antigen)
7.	HLA-B38 Antigen
8.	HLA-DRB1 Chains (HLA DRB1)
9.	HLA-DR4 Antigen (HLA DR4 Antigen)
10.	Histocompatibility Antigens Class I