Norisoprenoids (Irones)

Thirteen-carbon butene cyclohexene degradation products formed by the cleavage of CAROTENOIDS. They contribute to the flavor of some FRUIT. Ionone should not be confused with the similarly named ionol.

Also Known As:

Networked: 47 relevant articles (2 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Duan, Hong-Quan: 3 articles (10/2021 - 08/2015)
2.	Qin, Nan: 3 articles (10/2021 - 08/2015)
3.	Dong, Hong-Wei: 3 articles (10/2019 - 03/2013)
4.	Liu, Jia-Ren: 3 articles (10/2019 - 03/2013)
5.	Leray, Isabelle: 3 articles (10/2017 - 01/2014)
6.	Mir, Lluis M: 3 articles (10/2017 - 01/2014)
7.	Sanz, Guenhaël: 3 articles (10/2017 - 01/2014)
8.	Liu, Qian: 3 articles (08/2015 - 03/2013)
9.	Jia, Mei-Qi: 2 articles (10/2021 - 01/2021)
10.	Yu, Yang: 2 articles (10/2021 - 01/2021)

Related Diseases

1.	Hepatocellular Carcinoma (Hepatoma) 08/01/2012 - "Synergistic effects of the combination of β-ionone and sorafenib on metastasis of human hepatoma SK-Hep-1 cells." 08/01/2012 - "Using a highly invasive hepatoma SK-Hep-1 cell line, we investigated the possible synergistic anti-metastatic efficacy of a combination of sorafenib (SF), a multi-kinase inhibitor, and β-ionone (BI), a precursor of carotenoids. " 01/01/2020 - "The potential chemotherapeutic effect of β-ionone and/or sorafenib against hepatocellular carcinoma via its antioxidant effect, PPAR-γ, FOXO-1, Ki-67, Bax, and Bcl-2 signaling pathways."
2.	Carcinogenesis 06/01/2011 - "Efficacy of geraniol but not of β-ionone or their combination for the chemoprevention of rat colon carcinogenesis."
3.	Prostatic Neoplasms (Prostate Cancer) 12/28/2022 - "However, limited studies have revealed the role of β-ionone in regulating the epithelial-mesenchymal transition (EMT) of prostate cancer (PCa) cells. " 06/01/2015 - "Since NDRG1 impacts oncogenic signaling pathways interfering with tumor progression, we suggest that the Pyk2-NDRG1 axis is possibly involved in conveying the anti-proliferative effect of β-ionone in prostate cancer cells. " 02/15/2009 - "We report the SAR studies of 43 ionone-based chalcones that demonstrate substantial in vitro anti-proliferative activities in LNCaP, MDA-PCa-2b, 22Rv1, C4-2B and PC-3 prostate cancer cell lines. " 12/28/2022 - "β-ionone Inhibits Epithelial-Mesenchymal Transition (EMT) in Prostate Cancer Cells by Negatively Regulating the Wnt/β-Catenin Pathway." 01/01/2022 - "Here we demonstrate that β-ionone, an OR51E2 agonist, dose-dependently activates extracellular signal-regulated kinases 1 and 2 (ERK1/2) in prostate cancer cells, with an EC50 value of approximate 20 μM and an efficiency comparable to other receptor agonists. "
4.	Neoplasm Metastasis (Metastasis) 01/17/2017 - "In the present study, we show that even a relatively short exposure to β-ionone is sufficient to promote metastasis emergence. " 10/30/2017 - "LNCaP tumour cells, subcutaneously inoculated to immunodeficient mice, generated more metastases in vivo when β-ionone was applied through the skin. " 01/17/2017 - "We previously demonstrated that this receptor is able to promote LNCaP cell invasiveness in vitro upon stimulation with its odorant agonist β-ionone, leading to increased generation of metastases in vivo. " 01/01/2014 - "Finally, after subcutaneous inoculation of LNCaP cells into NSG immunodeficient mice, the in vivo stimulation of these cells by the PSGR agonist β-ionone significantly enhanced metastasis emergence and spreading. " 10/30/2017 - "We demonstrate that gallein can inhibit the β-ionone-induced cell invasiveness in vitro, as well as the spread of metastases in vivo. "
5.	Neoplasms (Cancer) 12/28/2022 - "In addition, β-ionone also inhibited the growth and EMT process of subcutaneous xenograft tumors in nude mice. " 12/28/2022 - "In recent years, accumulating evidence has shown that β-ionone exerts antitumor effects on various malignant tumors. " 12/10/2020 - "β-Ionone, whether of an endogenous or exogenous origin possesses a range of pharmacological effects including anticancer, chemopreventive, cancer promoting, melanogenesis, anti-inflammatory and antimicrobial actions. " 11/01/2020 - "In this paper, we synthesized a panel of β-ionone derivatives and tested their anti-proliferation activity on cancer cell by the MTT assay. " 01/17/2017 - "So, while structurally close, α-ionone and β-ionone appear to induce different cellular effects, both leading to increased tumor aggressiveness. "

Related Drugs and Biologics

1.	Carotenoids (Carotene)
2.	Phosphotransferases (Kinase)
3.	Sorafenib (BAY 43-9006)
4.	geraniol (nerol)
5.	Chalcones
6.	Alkaloids
7.	Propane
8.	Liposomes (Liposome)
9.	1,2- dioleoyloxy- 3- (trimethylammonium)propane
10.	trans-sialidase

Related Therapies and Procedures

1.	Chemoprevention
2.	Therapeutics
3.	Drug Therapy (Chemotherapy)