Abstract | BACKGROUND: β- ionone is a terminal cyclic analog of beta- carotenoids widely found in plants. In recent years, accumulating evidence has shown that β- ionone exerts antitumor effects on various malignant tumors. However, limited studies have revealed the role of β- ionone in regulating the epithelial-mesenchymal transition (EMT) of prostate cancer (PCa) cells. This study aimed to investigate the effect of β- ionone on the EMT process of PCa, focusing on Wnt/β- catenin signaling pathway. METHODS: RESULTS: The migration, invasion, and EMT process of PCa Human PC-3 prostate adenocarcinoma cells (PC3) and Human 22RV1 prostate adenocarcinoma cells (22RV1) cells were significantly inhibited after β- ionone treatment. In addition, β- ionone also inhibited the growth and EMT process of subcutaneous xenograft tumors in nude mice. The study also found that β- catenin, which promotes EMT, was downregulated after β- ionone treatment. Further mechanistic studies revealed that β- ionone inhibited the Wnt/β- catenin pathway by accelerating the ubiquitination and degradation of β- catenin in PCa, thus inhibiting the downstream migration, invasion, and EMT processes. CONCLUSIONS: These findings demonstrate that β- ionone may be a potential natural compound targeting the Wnt/β- catenin pathway for the treatment of PCa.
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Authors | Qixiang Fang, Taotao Que, Bo Liu, Weichao Dan, Yi Wei, Bingyi Ren, Yizeng Fan, Tao Hou, Jin Zeng |
Journal | Frontiers in bioscience (Landmark edition)
(Front Biosci (Landmark Ed))
Vol. 27
Issue 12
Pg. 335
(12 28 2022)
ISSN: 2768-6698 [Electronic] Singapore |
PMID | 36624947
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2022 The Author(s). Published by IMR Press. |
Chemical References |
- beta Catenin
- beta-ionone
- Glycogen Synthase Kinase 3
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Topics |
- Male
- Animals
- Mice
- Humans
- beta Catenin
(metabolism)
- Wnt Signaling Pathway
- Epithelial-Mesenchymal Transition
- Prostate
(metabolism)
- Mice, Nude
- Glycogen Synthase Kinase 3
(metabolism, pharmacology)
- Cell Movement
- Cell Proliferation
- Cell Line, Tumor
- Prostatic Neoplasms
(metabolism)
- Adenocarcinoma
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