Neural Cell Adhesion Molecule L1 (L1 Cell Adhesion Molecule)
A member of the immunoglobulin superfamily of neuronal cell adhesion molecules that is required for proper nervous system development. Neural cell adhesion molecule L1 consists of six Ig domains, five fibronectin domains, a transmembrane region and an intracellular domain. Two splicing variants are known: a neuronal form that contains a four-amino acid RSLE sequence in the cytoplasmic domain, and a non-neuronal form that lacks the RSLE sequence. Mutations in the L1 gene result in L1 disease. Neural cell adhesion molecule L1 is predominantly expressed during development in neurons and Schwann cells; involved in cell adhesion, neuronal migration, axonal growth and pathfinding, and myelination.
Also Known As:
L1 Cell Adhesion Molecule; CALL Protein; CamL1 Gene Product; Cell Adhesion Molecule L1; Cell Surface Glycoprotein L1; F11 Glycoprotein; L1CAM; NGF-Inducible Glycoprotein; NILE Glycoprotein; NILE Protein; Nerve Growth Factor-Inducible Large External Glycoprotein; Neural Adhesion Molecule L1; Glycoprotein, NGF-Inducible; Glycoprotein, NILE; NGF Inducible Glycoprotein; Nerve Growth Factor Inducible Large External Glycoprotein
Networked: 587
relevant articles (12 outcomes,
104 trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Experts
1. | Altevogt, Peter:
40 articles
(12/2020 - 07/2003)
|
2. | Schachner, Melitta:
33 articles
(12/2022 - 09/2002)
|
3. | Hong, Hyo Jeong:
13 articles
(01/2021 - 02/2009)
|
4. | Schäfer, Heiner:
13 articles
(12/2020 - 01/2009)
|
5. | Sebens, Susanne:
12 articles
(12/2020 - 08/2010)
|
6. | Schirmer, Uwe:
12 articles
(10/2018 - 04/2010)
|
7. | Pfeifer, Marco:
10 articles
(10/2018 - 03/2010)
|
8. | Zeimet, Alain G:
10 articles
(10/2018 - 04/2010)
|
9. | Moldenhauer, Gerhard:
10 articles
(03/2015 - 01/2006)
|
10. | Kiefel, Helena:
9 articles
(01/2014 - 05/2009)
|
Related Diseases
1. | Neoplasms (Cancer)
|
2. | Endometrial Neoplasms (Endometrial Cancer)
|
3. | Neoplasm Metastasis (Metastasis)
10/01/2010
- " Thus, the present study aims at further elucidating the role of L1CAM in a larger cohort of PDAC specimens including precursor lesions and metastasis. " 10/01/2023
- " A high L1CAM expression correlated with initial distant metastasis, advanced initial stage, lung metastasis, and the recurrence of MLA. " 11/01/2022
- " Positive L1CAM immunoexpression was noted in 26.7% and was significantly associated with grade, MI, LVSI, nodal metastasis, FIGO stage, and high-risk group ( P =0.003, P =0.023, P =0.003, P <0.001, P <0.001, P =0.002, respectively). " 05/18/2022
- " Positive staining for YAP/TAZ and L1CAM was associated with inferior LMOS, and YAP/TAZ was related to final liver metastasis." 05/18/2022
- " Positive staining for L1CAM and YAP/TAZ was associated with inferior survival, and YAP/TAZ was related to final liver metastasis. "
|
4. | Breast Neoplasms (Breast Cancer)
06/01/2023
- " Taken together, the findings of our study confirm the value of ZNF133 and L1CAM levels in the diagnosis and prognosis of breast cancer, contribute to a deeper understanding of the regulation mechanism of ZNF133 for the first time, and provide a new therapeutic strategy and precise intervention target for breast cancer." 01/01/2023
- " The survival of breast cancer patients was significantly associated with the low expressions of nine genes, including RACGAP1, KIAA1199, TIMM17A, LYRM7, IL1R1, SLC1A3, DTX4, L1CAM, and SAP30-like (SAP30L), and high expressions of two genes, SOD2 and HLA-DQB2. " 10/01/2018
- " L1 Cell Adhesion Molecule and Its Soluble Form sL1 Exhibit Poor Prognosis in Primary Breast Cancer Patients." 01/01/2015
- " L1CAM might be a potential therapeutic target against metastatic breast cancer." 01/01/2015
- " Our results suggest that the overexpression of L1CAM may be related to several established markers of poor prognosis in breast cancer patients. "
|
5. | Colorectal Neoplasms (Colorectal Cancer)
|
|
Related Drugs and Biologics
Related Therapies and Procedures