Platelet membrane glycoprotein complex important for platelet adhesion and aggregation. It is an integrin complex containing INTEGRIN ALPHAIIB and INTEGRIN BETA3 which recognizes the arginine-glycine-aspartic acid (RGD) sequence present on several adhesive proteins. As such, it is a receptor for FIBRINOGEN; VON WILLEBRAND FACTOR; FIBRONECTIN; VITRONECTIN; and THROMBOSPONDINS. A deficiency of GPIIb-IIIa results in GLANZMANN THROMBASTHENIA.
Also Known As:
Glycoproteins IIb-IIIa; Integrin alpha-IIb beta-3; GPIIb IIIa Receptors; Glycoproteins IIb IIIa; Integrin alpha IIb beta 3; Platelet Glycoprotein GPIIb IIIa Complex; Receptors, GPIIb-IIIa; alphaIIbbeta3, Integrin; beta-3, Integrin alpha-IIb; GPIIb-IIIa Receptors; Integrin alphaIIbbeta3