Quinone Reductases
NAD(P)H:(quinone acceptor) oxidoreductases. A family that includes three enzymes which are distinguished by their sensitivity to various inhibitors. EC 1.6.99.2 (NAD(P)H DEHYDROGENASE (QUINONE);) is a flavoprotein which reduces various quinones in the presence of NADH or NADPH and is inhibited by dicoumarol. EC 1.6.99.5 (NADH dehydrogenase (quinone)) requires NADH, is inhibited by AMP and 2,4-dinitrophenol but not by dicoumarol or folic acid derivatives. EC 1.6.99.6 (NADPH dehydrogenase (quinone)) requires NADPH and is inhibited by dicoumarol and folic acid derivatives but not by 2,4-dinitrophenol.
Also Known As:
Menaquinone Reductases; Reductases, Menaquinone; Reductases, Quinone
Networked: 10
relevant articles (2 outcomes,
0 trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Experts
1. | Kensler, T W:
2 articles
(09/2001 - 01/2000)
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2. | Ahmed, Nadeem:
1 article
(07/2015)
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3. | Badshah, Amin:
1 article
(07/2015)
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4. | Hussain, Raja Azadar:
1 article
(07/2015)
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5. | Kondratyuk, Tamara P:
1 article
(07/2015)
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6. | Park, Eun-Jung:
1 article
(07/2015)
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7. | Pezzuto, John M:
1 article
(07/2015)
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8. | Lüthje, Sabine:
1 article
(08/2011)
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9. | Meisrimler, Claudia-Nicole:
1 article
(08/2011)
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10. | Planchon, Sebastien:
1 article
(08/2011)
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Related Diseases
1. | Carcinogenesis
10/01/1990
- " The levels of quinone reductases, superoxide dismutase and glutathione-related enzymatic activities in diethylstilbestrol-induced carcinogenesis in the kidney of male Syrian golden hamsters." 01/01/2000
- " One of the major mechanisms of protection against carcinogenesis, mutagenesis, and other forms of toxicity mediated by carcinogens is the induction of enzymes involved in their metabolism, particularly phase 2 enzymes such as glutathione S-transferases, UDP-glucuronosyl transferases, and quinone reductases. " 09/01/2001
- " One of the major mechanisms of protection against carcinogenesis, mutagenesis, and other forms of toxicity mediated by carcinogens is the induction of enzymes involved in their metabolism, particularly phase 2 enzymes such as glutathione S-transferases (GSTs), UDP-glucuronosyl transferases, and quinone reductases. "
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2. | Neoplasms (Cancer)
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3. | Rupture
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4. | Infections
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5. | Urinary Bladder Neoplasms (Bladder Cancer)
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Related Drugs and Biologics