A zinc containing enzyme of the hydrolase class that catalyzes the removal of the N-terminal amino acid from most L-peptides, particularly those with N-terminal leucine residues but not those with N-terminal lysine or arginine residues. This occurs in tissue cell cytosol, with high activity in the duodenum, liver, and kidney. The activity of this enzyme is commonly assayed using a leucine arylamide chromogenic substrate such as leucyl beta-naphthylamide.
Also Known As:
Peptidase S; Leucine Aminopeptidase; L-Leucylnaphthylamidase; Methoxyleucine Aminopeptidase; Zinc-Manganese-Leucine Aminopeptidase; Aminopeptidase, Cytosol; Aminopeptidase, Leucine; Aminopeptidase, Leucyl; Aminopeptidase, Methoxyleucine; Aminopeptidase, Zinc-Manganese-Leucine; Zinc Manganese Leucine Aminopeptidase; Cytosol Aminopeptidase