Galactoside 2-alpha-L-fucosyltransferase (Fucosyltransferase 2)

Catalyzes the transfer of L-fucose to the terminal galactose residue of glycoconjugates through an alpha-(1,2) linkage leading to H antigen synthesis.

Also Known As:

Fucosyltransferase 2; Alpha-2-L-fucosyltransferase; Alpha-2-fucosyltransferase; Fucosyltransferase 1; GDP-L-fucose-beta-D-galactoside 2-alpha-L-fucosyltransferase; GDP-L-fucose-beta-D-galactosyl alpha-2-L-fucosyltransferase; GDP-L-fucose-galactoside-2'-fucosyltransferase; GDP-L-fucose-lactose fucosyltransferase; GDPFG-2-fucosyltransferase; Gal alpha1-2 fucosyltransferase; Galactoside 2-alpha-L-fucosyltransferase 1; Galactoside 2-alpha-L-fucosyltransferase 2; beta-galactoside alpha-1,2-fucosyltransferase; beta-galactoside alpha1,2-fucosyltransferase; Blood Group H Fucosyltransferase; Blood Group H alpha-2-fucosyltransferase; Galactoside 2-fucosyltransferase; Guanosine Diphosphofucose-glycoprotein 2-alpha-L-fucosyltransferase; Secretor Blood Group alpha-2-fucosyltransferase

Networked: 62 relevant articles (0 outcomes, 10 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Glycosyltransferases: 784
      - Hexosyltransferases
        Fucosyltransferases: 329
        Galactoside 2-alpha-L-fucosyltransferase: 62
        Drosophila o-fucosyltransferase 2
        human FUT1 protein
        human FUT2 protein
        mouse Fut1 protein
        mouse Fut2 protein
        rat Fut1 protein
        rat Fut2 protein

Experts

1.	Lerch, Markus M: 3 articles (02/2016 - 04/2015)
2.	Mayerle, Julia: 3 articles (02/2016 - 04/2015)
3.	Simon, Peter: 3 articles (02/2016 - 04/2015)
4.	Maftah, Abderrahman: 2 articles (05/2020 - 10/2018)
5.	Hirose, Koichi: 2 articles (01/2020 - 01/2019)
6.	Nakajima, Hiroshi: 2 articles (01/2020 - 01/2019)
7.	Saku, Aiko: 2 articles (01/2020 - 01/2019)
8.	Domino, Steven E: 2 articles (01/2019 - 08/2014)
9.	Goto, Yoshiyuki: 2 articles (01/2019 - 10/2016)
10.	Kiyono, Hiroshi: 2 articles (01/2019 - 10/2016)

Related Diseases

1.	Infections 01/01/2010 - "Infection-associated FUT2 (Fucosyltransferase 2) genetic variation and impact on functionality assessed by in vivo studies." 08/17/2021 - "Eighteen piglets susceptible to F18 VTEC infection were selected by polymerase chain reaction for polymorphism on the fucosyltransferase 1 gene and randomly divided in two experimental groups, non-infected controls (C; n = 6) and infected ones (I; n = 12) and housed into individual pens at the same environmental conditions for 29 days. " 01/01/2021 - "Being a "nonsecretor" (having an inactive fucosyltransferase-2 gene) protects against diarrhea by inhibiting enteric infections. " 02/01/2012 - "Genomewide association studies have shown a relation between plasma vitamin B-12 concentration and the 461G→A polymorphism of fucosyltransferase 2 (FUT2), a gene associated with susceptibility to Helicobacter pylori infection. " 10/19/2016 - "Dysregulation of the gene (FUT2) encoding fucosyltransferase 2, an enzyme governing epithelial α1,2-fucosylation, is associated with various human disorders, including infection and chronic inflammatory diseases. "
2.	Carcinogenesis 12/13/2022 - "Our previous studies showed that fucosyltransferase 2 (FUT2) is highly expressed in lung adenocarcinoma (LUAD) and plays a vital role in the tumorigenesis of LUAD. " 12/01/2023 - "Previous studies found that protein O-fucosyltransferase 1 (POFUT1) upregulation promotes carcinogenesis, although the potential roles, underlying molecular mechanisms, and biological implications of POFUT1 in HNSCC were not investigated. "
3.	Necrotizing Enterocolitis 01/01/2023 - "Retracted: A Study on Fucosyltransferase 2 Gene Polymorphism and Secretion Status Related to Neonatal Necrotizing Enterocolitis." 01/01/2021 - "A Study on Fucosyltransferase 2 Gene Polymorphism and Secretion Status Related to Neonatal Necrotizing Enterocolitis." 01/01/2021 - "To detect the single nucleotide polymorphism (SNP) of alpha-(1,2) fucosyltransferase 2 gene (FUT2) and the secretion status in the newborns of Chongqing China and explore the relationship between genotype or phenotype of FUT2 and neonatal necrotizing enterocolitis (NEC). "
4.	Neoplasms (Cancer) 01/01/2023 - "Fucosyltransferase 2(FUT2) and its induced α-1,2 fucosylation is associated with cancer metastasis. " 08/01/2022 - "CA19-9 levels genotypes and of fucosyltransferase 2 and 3 were analyzed in cancer-free and colorectal cancer patients. " 01/01/2023 - "Fucosyltransferase 2 (FUT2), catalyzing the α1, 2‑linked fucose in mammals, has been reported to be overexpressed in several malignant cancers, including CRC. " 01/01/2018 - "Fucosyltransferase 2 (FUT2), the enzyme catalyzing α-1,2-fucosylation in mammals, has been implicated in cancer. " 04/01/2016 - "The expression of Galα1-3(Fucα1-2)Gal (EEL) and fucosyltransferase 1 was mainly increasing in the cytoplasm of hepatocytes during PCTs-cirrhotic-tumor tissues progression, while the expression of T antigen (ACA and PNA) was decreased sharply in cytoplasm of tumor hepatocytes. "
5.	Colorectal Neoplasms (Colorectal Cancer) 08/01/2022 - "CA19-9 levels genotypes and of fucosyltransferase 2 and 3 were analyzed in cancer-free and colorectal cancer patients. " 07/11/2023 - "To analyse the effect of POFUT1 (Protein O-Fucosyltransferase 1) on the proliferation, migration and apoptosis of colorectal cancer (CRC) cells and to explore its potential mechanism. " 05/31/2020 - "Protein O-fucosyltransferase 1 (POFUT1) overexpression, which is observed in many cancers such as colorectal cancer (CRC), leads to a NOTCH signaling dysregulation associated with the tumoral process. " 10/30/2018 - "While protein O-fucosyltransferase 1 (POFUT1) overexpression has been recently proposed as a potential biomarker for different cancer types, no study was carried out on POFUT1 implication in colorectal cancer (CRC). "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Vitamins
3.	Vitamin B 12 (Cyanocobalamin)
4.	Lipase (Acid Lipase)
5.	Glucose (Dextrose)
6.	Blood Group Antigens (Blood Groups)
7.	Biomarkers (Surrogate Marker)
8.	Lipids
9.	Enzymes
10.	Fucose