Abstract | BACKGROUND: METHODS: The expression levels and clinical analyses of FUT2 were assessed in CRC samples. Migration and invasion assays, EMT detection, nude mice peritoneal dissemination models and intestinal specific FUT2 knockout mice (FUT2△IEC mice) were used to investigate the effect of FUT2 on metastasis in colorectal cancer. Quantitative proteomics study of glycosylated protein, UEA enrichment, Co-immunoprecipitation identified the mediator of the invasive-inhibiting effects of FUT2. RESULTS: CONCLUSIONS: Our study demonstrated that FUT2 induces α-1,2 fucosylation and inhibits EMT and metastasis of colorectal cancer through LRP1 fucosylation, suggesting that FUT2 may serve as a therapeutic target for colorectal cancer. Video Abstract.
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Authors | Lingnan He, Zijun Guo, Weijun Wang, Shuxin Tian, Rong Lin |
Journal | Cell communication and signaling : CCS
(Cell Commun Signal)
Vol. 21
Issue 1
Pg. 63
(03 27 2023)
ISSN: 1478-811X [Electronic] England |
PMID | 36973740
(Publication Type: Video-Audio Media, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2023. The Author(s). |
Chemical References |
- Low Density Lipoprotein Receptor-Related Protein-1
- Lrp1 protein, mouse
- galactoside 2-alpha-L-fucosyltransferase
- Fucosyltransferases
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Topics |
- Animals
- Mice
- Cell Line, Tumor
- Cell Movement
- Colorectal Neoplasms
(pathology)
- Epithelial-Mesenchymal Transition
- Gene Expression Regulation, Neoplastic
- Low Density Lipoprotein Receptor-Related Protein-1
(genetics)
- Mice, Nude
- Neoplasm Metastasis
- Fucosyltransferases
(genetics)
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