Peroxidasin

A peroxidase originally isolated from DROSOPHILA that catalyzes the oxidation of bromide by hydrogen peroxide and generates hypobromite as a reactive intermediate. Its functions include a role in EXTRACELLULAR MATRIX assembly of COLLAGEN TYPE IV; LAMININ; and FIBRONECTIN.

Also Known As:

Networked: 24 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Bhave, Gautam: 4 articles (01/2022 - 11/2018)
2.	Colon, Selene: 3 articles (01/2022 - 01/2019)
3.	Adisakwattana, Poom: 1 article (01/2022)
4.	Ataeinia, Bahar: 1 article (01/2022)
5.	Barrett, Stephen C: 1 article (01/2022)
6.	Caravan, Peter: 1 article (01/2022)
7.	Chen, Chunyu: 1 article (01/2022)
8.	Chung, Raymond T: 1 article (01/2022)
9.	Dong, Lei: 1 article (01/2022)
10.	Erstad, Derek J: 1 article (01/2022)

Related Diseases

1.	Angle-Closure Glaucoma (Glaucoma, Angle Closure) 11/01/2023 - "This study aimed to evaluate the association of body mass index (BMI) and the weight-related gene, peroxidasin-like (PXDNL), with acute primary angle closure (APAC) and primary angle-closure glaucoma (PACG) in southern Chinese population. "
2.	Fibrosis (Cirrhosis) 08/01/2009 - "We also demonstrate that peroxidasin expression is increased in a murine model of kidney fibrosis and that peroxidasin localizes to the peritubular space in fibrotic kidneys. " 01/01/2019 - "Peroxidasin and eosinophil peroxidase, but not myeloperoxidase, contribute to renal fibrosis in the murine unilateral ureteral obstruction model." 10/01/2021 - "Introduction: Enzymatic cross-linking of the collagens within the extracellular matrix (ECM) catalyzed by enzymes such as lysyl oxidase (LOX) and lysyl oxidase like-enzymes 1-4 (LOXL), transglutaminase 2 (TG2), and peroxidasin (PXDN) contribute to fibrosis progression through extensive collagen cross-linking. " 03/10/2018 - "Peroxidasin (PXDN), an ECM protein with peroxidase activity, is integral to basement membrane consolidation through catalysis of sulfilimine bonds in collagen IV. PXDN is also involved in processes where epithelial-mesenchymal transition (EMT) takes place, namely fibrosis, development and cancer. "
3.	Neoplasms (Cancer) 10/31/2023 - "This review highlights the current literature exploring the known roles of peroxidasin in normal tissues and cancer progression, regulators of peroxidasin expression, and the reported relationships between peroxidasin expression and patient outcome in cancer." 10/31/2023 - "The role of peroxidasin in solid cancer progression." 10/31/2023 - "Whilst peroxidasin is reported to be up-regulated in a number of different cancers, the role that it plays in disease progression and metastasis has only recently begun to be studied. " 10/01/2021 - "mRNA expression has been reported to be upregulated in metastatic melanoma cell lines and connected to the invasive phenotype, but little is known about how peroxidasin acts in cancer cells. " 10/31/2023 - "During cancer progression, the basement membrane is degraded, and proteins typically found in the basement membrane, including peroxidasin and collagen IV, can be found spread throughout the tumour microenvironment where they interact with cancer cells and alter cell behaviour. "
4.	Melanoma (Melanoma, Malignant) 10/01/2021 - "Peroxidasin protein expression and enzymatic activity in metastatic melanoma cell lines are associated with invasive potential." 10/01/2021 - "mRNA expression has been reported to be upregulated in metastatic melanoma cell lines and connected to the invasive phenotype, but little is known about how peroxidasin acts in cancer cells. " 10/01/2021 - "We have analyzed peroxidasin protein expression and activity in eight metastatic melanoma cell lines using an ELISA developed with an in-house peroxidasin binding protein. " 07/05/2016 - "We identified Peroxidasin (PXDN), Netrin 4 (NTN4) and GLIS Family Zinc Finger 3 (GLIS3) genes consistently elevated in invasive mesenchymal-like melanoma cells. " 10/01/2021 - "We found that peroxidasin secreted from melanoma cells formed sulfilimine bonds in uncross-linked collagen IV, confirming peroxidasin activity and hypobromous acid formation. "
5.	Glaucoma 09/09/2011 - "Here, we report homozygous mutations in peroxidasin (PXDN) in two consanguineous Pakistani families with congenital cataract-microcornea with mild to moderate corneal opacity and in a consanguineous Cambodian family with developmental glaucoma and severe corneal opacification. " 11/01/2014 - "Mutations in Peroxidasin (PXDN) cause severe inherited eye disorders in humans, such as congenital cataract, corneal opacity and developmental glaucoma. "

Related Drugs and Biologics

1.	5'- O- (9- phenylxanthen- 9- yl)- 2'- deoxynebularine
2.	Collagen
3.	Proteins (Proteins, Gene)
4.	Peroxidase (Myeloperoxidase)
5.	Heme (Haem)
6.	Enzymes
7.	sulfilimine
8.	Matrilin Proteins
9.	Fatty Acid Transport Proteins (Fatty Acid Transport Protein)
10.	Eosinophil Peroxidase