ATP-Binding Cassette Sub-Family B Member 4

An ATP-binding cassette, sub-family B protein that functions in translocating PHOSPHATIDYLCHOLINES from the inner to the outer leaflet of the canalicular membrane of the HEPATOCYTES.

Also Known As:

2, P-Glycoprotein; ABCB4, Phosphatidylcholine Translocator; ATP Binding Cassette Sub Family B Member 4; P Glycoprotein 2; Translocator ABCB4, Phosphatidylcholine; protein, Pgp2; MDR2 Protein; Multidrug Resistance Protein 2; P-Glycoprotein 2; Pgp2 protein; Phosphatidylcholine Translocator ABCB4

Networked: 114 relevant articles (1 outcomes, 17 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Beijnen, Jos H: 6 articles (10/2013 - 01/2006)
2.	Schinkel, Alfred H: 5 articles (01/2017 - 03/2005)
3.	Liu, Zhongqiu: 4 articles (01/2020 - 01/2016)
4.	Trauner, Michael: 4 articles (01/2020 - 08/2008)
5.	Zhu, Lijun: 4 articles (01/2020 - 01/2016)
6.	Hayashi, Hisao: 4 articles (04/2005 - 01/2003)
7.	Machida, Ikuo: 4 articles (04/2005 - 01/2003)
8.	Wakusawa, Shinya: 4 articles (04/2005 - 01/2003)
9.	Chu, Xiaoyan: 3 articles (01/2022 - 03/2013)
10.	DeMorrow, Sharon: 3 articles (01/2022 - 11/2017)

Related Diseases

1.	Liver Cirrhosis (Hepatic Cirrhosis) 01/01/2020 - "In this study, we assessed the role of Gal and its receptors, Gal receptor 1 (GalR1) and Gal receptor 2 (GalR2), in cholangiocyte proliferation and liver fibrosis in multidrug resistance protein 2 knockout (Mdr2KO) mice as a model of chronic hepatic cholestasis. " 01/01/2020 - "Coordinated Targeting of Galanin Receptors on Cholangiocytes and Hepatic Stellate Cells Ameliorates Liver Fibrosis in Multidrug Resistance Protein 2 Knockout Mice." 10/01/2022 - "PRI-724 suppressed liver fibrosis induced by multidrug resistance protein 2 knockout (KO), bile duct ligation, or a 3.5-diethoxycarbonyl-1.4-dihydrocollidine (DDC) diet; it also suppressed BA synthesis and macrophage infiltration. " 01/01/2017 - "To identify whether SP regulates liver fibrosis during cholestasis, wild-type or NK-1R knockout (NK-1R-/- ) mice that received BDL or sham surgery and multidrug resistance protein 2 knockout (Mdr2-/- ) mice treated with either an NK-1R antagonist (L-733,060) or saline were used. " 08/01/2001 - "Expression of the basolateral organic anion transporting polypeptide OATP-C (SLC21A6) and the canalicular multidrug resistance protein 2 (MRP2) was studied in patients with primary sclerosing cholangitis (PSC) (n=4), a chronic cholestatic liver disease, and in non-cholestatic controls (n=4) (two with chronic hepatitis C, one with idiopathic liver cirrhosis and one with fatty liver). "
2.	Breast Neoplasms (Breast Cancer) 01/01/2018 - "In this study, we aimed to investigate the role of ATP-binding cassette sub-family B, member 4 (ABCB4) in acquired doxorubicin resistance in breast cancer cells, as well as its potential mechanism. " 12/30/2015 - "The transport and cellular accumulation studies in Madin-Darby canine kidney (MDCK) cells overexpressing human multidrug resistance protein 2 (MRP2) or P-gp and LLC-PK1 cells overexpressing human breast cancer resistance protein (BCRP) were performed. " 01/01/2020 - "To explore the effects of breast cancer resistance protein (Bcrp) and multidrug resistance protein 2 (Mrp2) on the disposition of L-10-G. " 01/01/2020 - "Breast Cancer Resistance Protein and Multidrug Resistance Protein 2 Mediate the Disposition of Leonurine-10-O-β-glucuronide." 01/01/2019 - "Multiple transporter proteins were present in both primary-cell culture formats at levels similar to those present in freshly isolated crypts/villi; however, expression of breast cancer resistance protein (BCRP) and multidrug resistance protein 2 (MRP2) in the monolayers on the conventional scaffold was substantially less than that on the gradient cross-linked scaffold and freshly isolated crypts/villi. "
3.	Cholestasis 04/01/2015 - "Expression of Multidrug Resistance Protein 2 (mrp2) in the Liver and Kidney Cells of Female Rats with Modeled Cholestasis of Pregnancy." 01/01/2008 - "Cholestasis has been associated with the endocytic retrieval of multidrug resistance protein 2 (Mrp2), but its mechanism is still unclear. " 08/01/2001 - "Cholestasis induces down-regulation of multidrug resistance protein 2 (Mrp2, symbol Abcc2), which is localized to the canalicular membrane. " 01/01/2020 - "In this study, we assessed the role of Gal and its receptors, Gal receptor 1 (GalR1) and Gal receptor 2 (GalR2), in cholangiocyte proliferation and liver fibrosis in multidrug resistance protein 2 knockout (Mdr2KO) mice as a model of chronic hepatic cholestasis. " 10/01/2002 - "Down-regulation of multidrug resistance protein 2 (Mrp2), a major canalicular organic anion transporter, has been reported in various cholestatic models and in patients with cholestasis. "
4.	Fibrosis (Cirrhosis) 01/01/2021 - "Multidrug resistance protein 2 knockout (Mdr2-/-) mice develop spontaneous cholestatic liver injury and fibrosis mirroring human PSC. " 01/01/2019 - "We showed that LSCEVs were able to reduce ductular reaction and biliary fibrosis in multidrug resistance protein 2 (MDR2)-/- mice. " 01/01/2020 - "The purpose of this study was to examine the effects and to understand the mechanisms of the probiotic Lactobacillus rhamnosus GG (LGG) on hepatic BA synthesis, liver injury, and fibrosis in bile duct ligation (BDL) and multidrug resistance protein 2 knockout (Mdr2-/- ) mice. " 01/01/2012 - "We used microarray and metabolic profiling analyses to identify alterations in systemic and hepatic lipid metabolism in mice with disruption of the gene ATP-binding cassette sub-family B member 4 (Abcb4(-/-) mice), a model of inflammation-induced cholestatic liver injury, fibrosis, and cancer. " 11/01/2017 - "The impact of CD39 deletion on disease severity was studied in multidrug resistance protein 2 (Mdr2)-/- and 3,5-diethoxycarbonyl-1,4-dihydrocollidine mouse models of sclerosing cholangitis and biliary fibrosis. "
5.	Chronic Idiopathic Jaundice (Dubin Johnson Syndrome) 04/01/2005 - "Recent studies have indicated that dysfunction or loss of the multidrug resistance protein 2 (MRP2) is the molecular basis of Dubin-Johnson syndrome (DJS). " 05/01/2013 - "Mutation and functional analysis of ABCC2/multidrug resistance protein 2 in a Japanese patient with Dubin-Johnson syndrome." 02/01/2005 - "A novel ancestral splicing mutation in the multidrug resistance protein 2 gene causes Dubin-Johnson syndrome in Ashkenazi Jewish patients." 10/01/2004 - "Mutation analysis of the multidrug resistance protein 2 (MRP2) gene in a Japanese patient with Dubin-Johnson syndrome." 10/05/2001 - "Identification and functional analysis of two novel mutations in the multidrug resistance protein 2 gene in Israeli patients with Dubin-Johnson syndrome."

Related Drugs and Biologics

1.	Galanin Receptors (Galanin Receptor)
2.	Proteins (Proteins, Gene)
3.	Member 1 Subfamily B ATP Binding Cassette Transporter
4.	Peptides (Polypeptides)
5.	Anions
6.	Organic Anion Transporters
7.	Adenosine Triphosphate (ATP)
8.	Cytochrome P-450 CYP3A
9.	Rosuvastatin Calcium (Crestor)
10.	Tamoxifen

Related Therapies and Procedures

1.	Ligation
2.	Drug Therapy (Chemotherapy)
3.	Intravenous Administration
4.	Bioreactors (Bioreactor)