Transcriptional Coactivator with PDZ-Binding Motif Proteins

A family of signal transducing adaptor proteins that are similar in structure and function to YAP-SIGNALING PROTEINS. They are components of the HIPPO-SIGNALING PATHWAY, and may act as transcriptional co-activators for TEAD TRANSCRIPTION FACTORS.

Also Known As:

TAZ Signaling Proteins; Transcriptional Coactivator with PDZ Binding Motif Protein; Transcriptional Coactivator with PDZ Binding Motif Proteins; WW Domain Containing Transcription Regulator Protein 1; TAZ-Signaling Proteins; Transcriptional Coactivator with PDZ-Binding Motif (TAZ) Proteins; Transcriptional Coactivator with PDZ-Binding Motif Protein; WW Domain Containing Transcription Regulator 1; WW Domain-Containing Transcription Regulator Protein 1

Networked: 22 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Breuhahn, Kai: 2 articles (10/2021 - 01/2020)
2.	Schirmacher, Peter: 2 articles (10/2021 - 01/2020)
3.	Sticht, Carsten: 2 articles (10/2021 - 01/2020)
4.	Weiler, Sofia M E: 2 articles (10/2021 - 01/2020)
5.	Chae, Min Jee: 1 article (04/2022)
6.	Choi, Hye Jin: 1 article (04/2022)
7.	Kim, Do Young: 1 article (04/2022)
8.	Moon, Hyuk: 1 article (04/2022)
9.	Park, Hyunjung: 1 article (04/2022)
10.	Ro, Simon Weonsang: 1 article (04/2022)

Related Diseases

1.	Cardiovascular Diseases (Cardiovascular Disease) 01/14/2023 - "Based on preclinical studies on YAP/TAZ signaling proteins in cellular/animal models and clinical patients, the potential roles of YAP/TAZ proteins in some cardiovascular diseases (CVDs) are summarized."
2.	Neoplasms (Cancer) 11/04/2021 - "As an important component of the Hippo pathway, WW domain-containing transcription regulator 1 (TAZ), is a transcriptional coactivator that is responsible for the progression of various types of cancers. " 06/21/2021 - "This review aims to summarize and present the state of the art knowledge about the role of YAP in cancer signaling, first focusing on how YAP differs from WW domain-containing transcription regulator 1 (WWTR1, also named as TAZ) and which upstream factors regulate it; then, this review focuses on the role of YAP in different cancer stages and in the crosstalk between immune and cancer cells as well as growing translational strategies derived from its inhibitory and synergistic effects with existing chemo-, immuno- and radiotherapies." 01/01/2023 - "However, whether WW domain-containing transcription regulator 1 (WWTR1, also known as TAZ) can be packaged into exosomes by NDFIP1 and if so, whether the release of this oncogenic protein via exosomes has an effect on tumor development has not been investigated to any extent. " 12/01/2021 - "LOC107985656 could activate the tumor-suppressive Hippo pathway by repressing yes association protein (YAP) and WW domain-containing transcription regulator protein 1 (WWTR1, also known as TAZ) (two homologs of Yki) protein expression in HCC. " 01/01/2019 - "Yes-associated protein (YAP)/WW domain-containing transcription regulator 1 (TAZ) is an important transcriptional regulator and effector of the Hippo signaling pathway that has emerged as a critical determinant of malignancy in many human tumors. "
3.	Hepatocellular Carcinoma (Hepatoma) 01/01/2020 - "The Hippo pathway effectors yes-associated protein (YAP) and WW domain containing transcription regulator 1 (TAZ/WWTR1) support tumor initiation and progression in various cancer entities including hepatocellular carcinoma (HCC). " 04/19/2022 - "Transcription factors, yes-associated protein (YAP) and WW domain-containing transcription regulator protein 1 (WWTR1, also known as TAZ) have emerged as critical regulators in human hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC), the two major types of primary liver cancer. " 12/01/2021 - ":HCC: hepatocellular carcinoma; LncRNA: long non-coding RNA; LATS1: large tumor suppressor 1; MTT: 3-(4, 5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide; YAP: yes association protein; WWTR1: WW domain-containing transcription regulator protein 1; cDNA: single-stranded complementary DNA; RT-qPCR: real-time quantitative polymerase chain reaction; Radio-Immunoprecipitation Assay (RIPA); BCA: bicinchoninic acid; ASO: antisense oligonucleotide; MST1/2: Ste20-like kinases 1/2; TEAD: TEA domain transcription factor; ceRNA: competing endogenous RNAs."
4.	Cholangiocarcinoma 10/06/2021 - "Activation of the oncogene yes-associated protein (YAP) is frequently detected in intrahepatic cholangiocarcinoma (iCCA); however, the expression pattern and the functional impact of its paralogue WW domain-containing transcription regulator 1 (WWTR1; synonym: TAZ) are not well described in different CCA subtypes. " 04/19/2022 - "Transcription factors, yes-associated protein (YAP) and WW domain-containing transcription regulator protein 1 (WWTR1, also known as TAZ) have emerged as critical regulators in human hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC), the two major types of primary liver cancer. "
5.	Squamous Cell Carcinoma of Head and Neck 12/03/2019 - "Expression of genes controlled by the Hippo downstream transcriptional coactivators YAP (Yes-associated protein 1) and TAZ (WWTR1, WW domain containing transcription regulator 1) is widely deregulated in human cancer including head and neck squamous cell carcinoma (HNSCC). " 10/01/2019 - "Here, we aimed to investigate the expression of a novel lncRNA WW domain containing transcription regulator 1 antisense RNA 1 (WWTR1-AS1) as well as its clinical significance and biological roles in HNSCC. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Transcription Factors (Transcription Factor)
3.	Phosphotransferases (Kinase)
4.	Long Noncoding RNA
5.	Sirolimus (Rapamycin)
6.	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)
7.	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)
8.	Calmodulin (Calcium-Dependent Activator Protein)
9.	TEA Domain Transcription Factors
10.	AMP-Activated Protein Kinases

Related Therapies and Procedures

1.	Radiotherapy