The Emerging Role of YAP/TAZ in Tumor Immunity.

Abstract

Yes-associated protein (YAP)/WW domain-containing transcription regulator 1 (TAZ) is an important transcriptional regulator and effector of the Hippo signaling pathway that has emerged as a critical determinant of malignancy in many human tumors. YAP/TAZ expression regulates the cross-talk between immune cells and tumor cells in the tumor microenvironment through its influence on T cells, myeloid-derived suppressor cells, and macrophages. However, the mechanisms underlying these effects are poorly understood. An improved understanding of the role of YAP/TAZ in tumor immunity is essential for exploring innovative tumor treatments and making further breakthroughs in antitumor immunotherapy. This review primarily focuses on the role of YAP/TAZ in immune cells, their interactions with tumor cells, and how this impacts on tumorigenesis, progression, and therapy resistance.

• Authors: Zhaoji Pan, Yiqing Tian, Chengsong Cao, Guoping Niu
• Journal: Molecular cancer research : MCR (Mol Cancer Res) Vol. 17 Issue 9 Pg. 1777-1786 (09 2019) ISSN: 1557-3125 [Electronic] United States
• PMID: 31308148 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: ©2019 American Association for Cancer Research.

Chemical References

• Trans-Activators
• Transcriptional Coactivator with PDZ-Binding Motif Proteins
• WWTR1 protein, human

Topics

• Disease Progression
• Gene Expression Regulation, Neoplastic
• Humans
• Macrophages (metabolism)
• Myeloid-Derived Suppressor Cells (metabolism)
• Neoplasms (immunology, metabolism)
• T-Lymphocytes (metabolism)
• Trans-Activators (metabolism)
• Transcriptional Coactivator with PDZ-Binding Motif Proteins
• Tumor Microenvironment