Cytochrome P-450 CYP2J2 (CYP2J2)

A cytochrome P450 enzyme involved in oxidizing POLYUNSATURATED FATTY ACIDS (PUFA) to PUFA epoxides which function as potent lipid mediators. This enzyme, encoded by CYP2J2 gene, metabolizes ARACHIDONIC ACID to epoxyeicosatrienoic acids (EETs) which produce biological effects including VASODILATION.

Also Known As:

CYP2J2; Acid Epoxygenase, Arachidonic; Cytochrome P 450 Arachidonate Oxygenase; Cytochrome P 450 CYP2J2; Epoxygenase, Arachidonate; Epoxygenase, Arachidonic Acid; NADPH Dependent Arachidonic Acid Epoxygenase; Arachidonate Epoxygenase; Arachidonic Acid Epoxygenase; Cytochrome P-450 Arachidonate Oxygenase; Cytochrome P-450 Epoxygenase; NADPH-Dependent Arachidonic Acid Epoxygenase

Networked: 185 relevant articles (17 outcomes, 58 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Zeldin, Darryl C: 31 articles (05/2020 - 09/2004)
2.	Wang, Dao Wen: 29 articles (01/2018 - 06/2005)
3.	Chen, Chen: 19 articles (12/2021 - 07/2007)
4.	Xu, Xizhen: 12 articles (01/2018 - 12/2010)
5.	Edin, Matthew L: 12 articles (01/2017 - 07/2007)
6.	Murray, Michael: 6 articles (11/2017 - 08/2003)
7.	Wang, Peihua: 6 articles (01/2017 - 11/2011)
8.	Bradbury, J Alyce: 6 articles (05/2016 - 09/2004)
9.	Zhao, Gang: 5 articles (08/2020 - 11/2011)
10.	Lemaitre, Rozenn N: 5 articles (05/2020 - 06/2008)

Related Diseases

1.	Neoplasms (Cancer) 02/01/2012 - "Therefore, combined inhibition of COX-2 and 5-LO or CYP2J2 may be one way to overcome low efficacy of single inhibition of COX-2 in cancer cells. " 02/01/2012 - "From these observations, we hypothesized that AA metabolism by 5-LO and/or CYP2J2 may lower the efficacy of anti-cancer effect by COX-2 inhibition. " 01/01/2021 - "In this study, expression levels of CYP2J2 in various cancer types were determined using the Oncomine, the Gene Expression Profiling Interactive Analysis (GEIPA), DriverDBv3, UALCAN, and Tumor Immune Estimation Resource (TIMER) databases. " 08/01/2013 - "With the increasing awareness of its roles in cancer disease and drug metabolism, studies about CYP2J2 are still going on, and various inhibitors of CYP2J2 have been determined. " 02/01/2010 - "The CYP2J2 polymorphism was genotyped in 5740 participants of the cardiovascular cohort of the 'Malmö Diet and Cancer' study. "
2.	Ischemia 09/03/2004 - "CYP2J2 Tr hearts have improved recovery of left ventricular developed pressure (LVDP) compared with wild-type (WT) hearts after 20 minutes ischemia and 40 minutes reperfusion. " 03/01/2022 - "Corrigendum to "ROS-responsive nanoparticle-mediated delivery of CYP2J2 gene for therapeutic angiogenesis in severe hindlimb ischemia" [Materials Today Bio 13(2022) 100192]." 01/01/2022 - "In summary, 3S-PLGA-po-PEG/CYP2J2-pDNA complexes have tremendous potential and provide a practical strategy for the treatment of limb ischemia. " 01/01/2022 - "ROS-responsive nanoparticle-mediated delivery of CYP2J2 gene for therapeutic angiogenesis in severe hindlimb ischemia." 01/01/2014 - "We found that CYP2J2 overexpression markedly decreased the levels of oxidative stress and cell apoptosis in lung tissues induced by ischemia/reperfusion. "
3.	Cardiomegaly (Heart Hypertrophy) 01/01/2020 - "Conversely, a cardiotropic adeno-associated viral vector (AAV9) encoding CYP2J2 prevented transverse aortic constriction-induced cardiac hypertrophy with preserved ejection fraction. " 10/01/2016 - "We investigated whether CYP2J2 and its metabolites EETs protected against cardiac hypertrophy by activating AMPKα2 and Akt1. " 10/01/2016 - "Although the functional roles of AMPK and Akt are well established, the significance of cross talk between them in the development of cardiac hypertrophy and antihypertrophy of CYP2J2 and EETs remains unclear. " 10/01/2016 - "Our studies reveal a novel mechanism in which CYP2J2 and EETs enhanced Akt1 nuclear translocation through interaction with AMPKα2β2γ1 and protect against cardiac hypertrophy and suggest that overexpression of CYP2J2 might have clinical potential to suppress cardiac hypertrophy and heart failure." 01/01/2013 - "CYP2J2 overexpression protects against arrhythmia susceptibility in cardiac hypertrophy."
4.	Hypertension (High Blood Pressure) 01/01/2019 - "A comprehensive study revealed SNP-SNP interactions and a sex-dependent relationship between polymorphisms of the CYP2J2 gene and hypertension risk." 09/01/2012 - "This study showed positive association of CYP2J2 gene polymorphism with hypertension among Saudi cases." 07/01/2007 - "Evidence from animal models and human studies suggests that CYP2J2 plays a mechanistic role in the development of hypertension. " 12/31/2023 - "MiR-3646 accelerates inflammatory response of Ang II-induced hVSMCs via CYP2J2/EETs axis in hypertension model." 09/01/2012 - "CYP2J2 -50 G/T and ADRB2 G46A gene polymorphisms in Saudi subjects with hypertension."
5.	Insulin Resistance 01/01/2018 - "In this study, we investigated the effects of endothelium-specific CYP2J2 overexpression on age-related insulin resistance and metabolic dysfunction. " 01/01/2018 - "Collectively, our findings indicated that endothelium-specific CYP2J2 overexpression alleviated age-related insulin resistance and metabolic dysfunction, which highlighted CYP epoxygenase-EET system as a potential target for combating aging-related metabolic disorders." 01/01/2018 - "Endothelium-specific CYP2J2 overexpression attenuates age-related insulin resistance." 01/01/2017 - "CYP2J2 and Its Metabolites EETs Attenuate Insulin Resistance via Regulating Macrophage Polarization in Adipose Tissue." 02/15/2015 - "All of the findings suggest that CYP2J2 expression attenuates the diabetic phenotype and insulin resistance via inhibition of NF-κB and MAPK signaling pathways and activation of PPARγ. "

Related Drugs and Biologics

1.	Cytochrome P-450 Enzyme System (Cytochrome P450)
2.	Acids
3.	Glucose (Dextrose)
4.	Peroxisome Proliferator-Activated Receptors (PPAR)
5.	Fatty Acids (Saturated Fatty Acids)
6.	1,1-dimethylbutyl-1-deoxy-Delta(9)-THC
7.	Reactive Oxygen Species (Oxygen Radicals)
8.	Doxorubicin (Adriamycin)
9.	Cannabinoid Receptors (Cannabinoid Receptor)
10.	Calcineurin

Related Therapies and Procedures

1.	Nephrectomy
2.	Drug Therapy (Chemotherapy)
3.	Therapeutics
4.	Castration
5.	Oral Administration