Kruppel-Like Factor 4

A member of zinc finger-containing transcription factors that belongs to the KRUPPEL-LIKE FACTOR family, involved in the regulation of diverse cellular processes such as cell growth, proliferation, differentiation, and APOPTOSIS.

Also Known As:

4, Krueppel-Like-Factor; 4, Kruppel-Like Factor; Endothelial Kruppel Like Zinc Finger Protein; Factor 4, Kruppel-Like; Factor, Gut-Enriched Kruppel-Like; Gut Enriched Kruppel Like Factor; Kruppel Like Factor 4; Protein, EZF; Protein, GKLF; Protein, Klf4; EZF Protein; Endothelial Kruppel-Like Zinc Finger Protein; Epithelial Zinc Finger Protein; GKLF Protein; Gut-Enriched Kruppel-Like Factor; Klf4 Protein; Krueppel-Like-Factor 4

Networked: 151 relevant articles (1 outcomes, 12 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Transcription Factors: 38804
    - Kruppel-Like Transcription Factors: 252
      - Kruppel-Like Factor 4: 151
        human KLF4 protein
        mouse Klf4 protein
        rat Klf4 protein
  - DNA-Binding Proteins: 2009
    - Kruppel-Like Transcription Factors: 252
      - Kruppel-Like Factor 4: 151
        human KLF4 protein
        mouse Klf4 protein
        rat Klf4 protein

Experts

1.	Xie, Keping: 4 articles (09/2012 - 04/2005)
2.	Chen, Xi: 3 articles (01/2020 - 03/2006)
3.	Liu, Chunming: 3 articles (11/2017 - 03/2006)
4.	Wei, Daoyan: 3 articles (09/2012 - 04/2005)
5.	Wang, Hui: 2 articles (05/2022 - 10/2019)
6.	Lai, Maode: 2 articles (08/2021 - 08/2008)
7.	Hippenstiel, Stefan: 2 articles (01/2021 - 02/2013)
8.	Keller, Susanna R: 2 articles (01/2021 - 01/2018)
9.	Suttorp, Norbert: 2 articles (01/2021 - 02/2013)
10.	Zahlten, Janine: 2 articles (01/2021 - 02/2013)

Related Diseases

1.	Ischemia 11/01/2020 - "Downregulation of miR-34a ameliorates inflammatory response and apoptosis induced by renal ischemia-reperfusion by promoting Kruppel-like factor 4 expression." 11/01/2020 - "To explore the influence of micro ribonucleic acid (miR)-34a on renal ischemia-reperfusion by regulating Kruppel-like factor 4 (KLF4). "
2.	Neoplasms (Cancer) 01/01/2021 - "Moreover, CXCL8 stimulation reduced KLF4 protein expression and promoted GC cell proliferation and migration, eventually promoting neoplasm growth in vivo. " 01/01/2019 - "Western blotting and IHC revealed relatively higher levels of KLF4 protein in mammary tumor sections from BITC-treated mice in comparison with controls, but the difference was insignificant. " 10/01/2018 - "Through analysis of the gene expression in patient samples, a decrease in miR-145 and an increase in Kruppel-like factor 4 (KLF4) in tumor tissues compared with adjacent normal tissues was observed. " 01/23/2017 - "The expressions of Kruppel-like factor 4 (KLF4) in ZNF750-depleted ESCC cells and its derived tumor tissue xenograft in nude mice were significantly down-regulated. " 07/01/2016 - "The KLF4 protein expression level was tested and evaluated by immunohistochemical analysis in 47 lung tumors and normal tissues, and then correlated with clinical characteristics. "
3.	Squamous Cell Carcinoma (Epidermoid Carcinoma) 06/01/2017 - "Kaplan-Meier analysis indicates that locally advanced cervical squamous cell carcinoma patients with high Kruppel-like factor 4 expression showed worse progression-free survival and overall survival. " 06/01/2017 - "The aim of this study was to explore the associations of Kruppel-like factor 4 expression with sensitivity to radiation therapy in locally advanced cervical squamous cell carcinoma patients. " 06/01/2017 - "Univariate and multivariate Cox regression model analyses suggest that the high Kruppel-like factor 4 expression was one of the high-risk factors associated with poor prognosis in locally advanced cervical squamous cell carcinoma patients after radiation therapy. " 06/01/2017 - "The records of 117 locally advanced cervical squamous cell carcinoma patients were retrospectively reviewed, and Kruppel-like factor 4 expression in cervical carcinoma tissues was examined by immunohistochemical staining. " 05/01/2008 - "Increased expression of KLF4 protein and mRNA were found in squamous cell carcinoma cell line studies and fresh skin tissue respectively, using western blotting and semi-quantitative real time polymerase chain reaction (PCR). "
4.	Inflammation (Inflammations) 01/01/2021 - "Our previous research demonstrates that myeloid-derived suppressor cells (MDSCs) accumulate during inflammation and promote chronic wound healing via the regulation of Kruppel-like factor 4 (KLF4). " 11/04/2017 - "We recently reported that Kruppel-like factor 4 (KLF4) regulates MDSC differentiation into fibrocytes, emerging effectors in chronic inflammation. " 06/20/2008 - "Kruppel-like factor 4: transcriptional regulator of proliferation, or inflammation, or differentiation, or all three?" 05/04/2007 - "Kruppel-like factor 4 regulates endothelial inflammation." 01/01/2021 - "Given that perivascular cell KLF4 (kruppel-like factor 4) can have beneficial or detrimental effects, we tested its role in obesity-associated AT inflammation. "
5.	Stomach Neoplasms (Stomach Cancer) 01/01/2021 - "Kruppel-like factor 4 (KLF4) is a potential tumour suppressor in gastric cancer (GC). " 01/01/2015 - "In addition, KLF4 protein in gastric cancer cell lines and 30 GC tissues was measured by western blotting and immunochemistry, respectively. " 07/01/2012 - "To explore the expression of gut-enriched Kruppel-like factor 4(KLF4) in gastric cancer, and its association with prognosis. " 07/01/2012 - "[Association between gut-enriched Kruppel-like factor and prognosis of patients with gastric cancer]." 10/01/2018 - "Negative Regulation of Kruppel-Like Factor 4 on microRNA-106a at Upstream Transcriptional Level and the Role in Gastric Cancer Metastasis."

Related Drugs and Biologics

1.	Kruppel-Like Transcription Factors (Kruppel-Like Factors)
2.	Messenger RNA (mRNA)
3.	Peroxisome Proliferator-Activated Receptors (PPAR)
4.	Catenins
5.	Cytokines
6.	Transcription Factors (Transcription Factor)
7.	Proteins (Proteins, Gene)
8.	MicroRNAs (MicroRNA)
9.	Transcription Factor 4
10.	PPAR gamma

Related Therapies and Procedures

1.	Radiotherapy
2.	Therapeutics
3.	Resuscitation