Mirtazapine (Rexer)

A piperazinoazepine tetracyclic compound that enhances the release of NOREPINEPHRINE and SEROTONIN through blockage of presynaptic ALPHA-2 ADRENERGIC RECEPTORS. It also blocks both 5-HT2 and 5-HT3 serotonin receptors and is a potent HISTAMINE H1 RECEPTOR antagonist. It is used for the treatment of depression, and may also be useful for the treatment of anxiety disorders.

Also Known As:

Networked: 1039 relevant articles (191 outcomes, 244 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Tiihonen, Jari: 10 articles (12/2021 - 03/2009)
2.	Joffe, Grigori: 9 articles (01/2022 - 03/2009)
3.	Trivedi, Madhukar H: 8 articles (12/2019 - 07/2006)
4.	Burkin, Mark: 8 articles (01/2017 - 03/2009)
5.	Stenberg, Jan-Henry: 8 articles (01/2017 - 03/2009)
6.	Naguy, Ahmed: 7 articles (01/2022 - 11/2018)
7.	Weizman, Abraham: 7 articles (01/2022 - 06/2003)
8.	Lee, Min-Soo: 7 articles (05/2015 - 01/2007)
9.	Joffe, Marina: 7 articles (08/2013 - 03/2009)
10.	Pae, Chi-Un: 7 articles (02/2008 - 04/2002)

Related Diseases

1.	Nausea 01/01/2012 - "However, refractory nausea was diagnosed because it did not improve, and mirtazapine at a daily dose of 7. 5 mgbefore bedtime was started. " 07/01/2000 - "Mirtazapine for the treatment of depression and nausea in breast and gynecological oncology." 01/01/2012 - "[Low-dose mirtazapine improved nausea and appetite loss during S-1 therapy]." 01/01/2012 - "We conclude that low-dose mirtazapine is one effective option for refractory nausea duringS -1 therapy." 01/01/2017 - "Mirtazapine significantly improved both nausea and vomiting in gastroparetics after 2 and 4 weeks of treatment. "
2.	Sleep Initiation and Maintenance Disorders (Insomnia) 07/01/2015 - "Two weeks of treatment with esmirtazapine consistently and significantly improved patient-reported sleep parameters, and it was well tolerated in patients with primary insomnia." 11/01/2023 - "In late-life depression, mirtazapine showed faster HAM-D total score improvement (3.3 points difference, p = 0.021) and higher improvement in insomnia (1.7 points difference, p = 0.001) and appetite (1.2 points difference, p = 0.020). " 02/01/2020 - "Treatment with mirtazapine for 11 months resulted in the remission of the disordered eating behaviour, a sustained regain of weight, a score of 41-points on the ORTO-15, and to the resolution of depressive symptomatology (including insomnia). " 01/01/2018 - "Effective Treatment of Insomnia With Mirtazapine Attenuates Concomitant Suicidal Ideation." 03/01/2015 - "Mirtazapine may be a treatment of interest when a fast remission of depressive symptoms (especially insomnia) is warranted but its tolerance profile makes it difficult to use. "
3.	Major Depressive Disorder (Major Depressive Disorders) 01/01/2019 - "Patients on mirtazapine showed significant improvement in symptoms of major depressive disorder within the first 1-2 weeks of treatment with long-term studies at 40 weeks showing continued improvements in response rates in addition to lower relapse rates. " 01/01/2016 - "Early Improvements in Individual Symptoms to Predict Later Remission in Major Depressive Disorder Treated With Mirtazapine." 05/01/2000 - "Nineteen patients (12 women and 7 men), with SSRI-induced sexual dysfunction who were in remission from major depressive disorder (total Hamilton Rating Scale for Depression [HAM-D] score < or = 10), were switched to open-label mirtazapine for up to 6 weeks. " 01/01/2018 - "We used the equipercentile linking method to identify corresponding scores of simultaneous HAM-D and MADRS ratings in 4388 patients from 31 mirtazapine trials in major depressive disorder. " 04/01/2015 - "Data from a 6-week double-blind randomized placebo-controlled trial of mirtazapine in major depressive disorder (DSM-IV) conducted from November 2004 to December 2005 were used. "
4.	Schizophrenia (Dementia Praecox) 04/01/2011 - "In this study, the efficacy of add-on mirtazapine on depression in schizophrenia was explored in a subsidiary arm of a recent randomized controlled trial. " 08/01/2010 - "Adjunctive mirtazapine improved negative symptoms of schizophrenia in several studies. " 04/01/2009 - "This study investigates the efficacy of adding mirtazapine to treatment as usual to alleviate the negative symptoms of schizophrenia. " 01/01/2015 - "To assess the efficacy of mirtazapine as an adjunctive treatment of negative symptoms in patients with chronic schizophrenia via meta-analysis. " 01/01/2015 - "Meta-Analysis of Efficacy of Mirtazapine as an Adjunctive Treatment of Negative Symptoms in Schizophrenia."
5.	Vomiting 07/01/2011 - "The aim of this case report was to evaluate the psychiatric co-morbidity and efficacy of mirtazapine treatment in young subjects with chronic or cyclic vomiting syndromes. " 07/01/2011 - "Psychiatric Co-morbidity and Efficacy of Mirtazapine Treatment in Young Subjects With Chronic or Cyclic Vomiting Syndromes: A Case Series." 07/01/2011 - "An open trial of mirtazapine was conducted for the treatment and/or prevention of vomiting. " 01/01/2016 - "Use of mirtazapine in functional vomiting." 09/01/2013 - "Compared to placebo, mirtazapine administration resulted in a statistically significant increase in appetite (P=0.02) and activity (P=0.02) and a statistically significant decrease in vomiting (P=0.047), as determined by Wilcoxon matched pairs analysis. "

Related Drugs and Biologics

1.	Antidepressive Agents (Antidepressants)
2.	Venlafaxine Hydrochloride (Effexor)
3.	Selective Serotonin Reuptake Inhibitors (Serotonin Reuptake Inhibitors)
4.	Tricyclic Antidepressive Agents (Tricyclic Antidepressants)
5.	Mefloquine (Lariam)
6.	Antipsychotic Agents (Antipsychotics)
7.	Gabapentin (Neurontin)
8.	Sertraline (Zoloft)
9.	Amitriptyline (Elavil)
10.	Serotonin (5 Hydroxytryptamine)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Aftercare (After-Treatment)
4.	Renal Dialysis (Hemodialysis)
5.	Induced Hyperthermia (Thermotherapy)