A semisynthetic camptothecin derivative that inhibits DNA TOPOISOMERASE I to prevent nucleic acid synthesis during S PHASE. It is used as an antineoplastic agent for the treatment of COLORECTAL NEOPLASMS and PANCREATIC NEOPLASMS.
Also Known As:
Camptosar; CPT 11; SN 38; 7-Ethyl-10-hydroxycamptothecin; CPT-11; Camptothecin-11; Irinotecan Hydrochloride; Irrinotecan; NK012 Compound; SN 38 11; SN-38; SN-38-11; 7 Ethyl 10 hydroxycamptothecin; CPT11; Camptothecin 11; SN3811; (1,4'-Bipiperidine)-1'-carboxylic acid, (4S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinolin-9-yl ester