Myristoylated Alanine-Rich C Kinase Substrate

A membrane and ACTIN CYTOSKELETON associated, N-terminal myristoylated protein that binds CALMODULIN and is a prominent substrate for PROTEIN KINASE C. Both phosphorylation and poly(ADP)-ribosylation inhibit its F-ACTIN crosslinking activity; phosphorylation also causes MARCKS to relocate from the membrane to cytoplasm.

Also Known As:

Networked: 81 relevant articles (0 outcomes, 5 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Adler, Kenneth B: 7 articles (01/2022 - 09/2010)
2.	Chen, Ching-Hsien: 6 articles (01/2021 - 04/2014)
3.	Anderson, Joshua C: 5 articles (11/2020 - 06/2012)
4.	Hicks, Patricia H: 5 articles (11/2020 - 06/2012)
5.	Willey, Christopher D: 5 articles (11/2020 - 06/2012)
6.	Jarboe, John S: 4 articles (06/2019 - 06/2012)
7.	Wu, Reen: 4 articles (01/2019 - 04/2014)
8.	Eustace, Nicholas J: 3 articles (11/2020 - 03/2017)
9.	Gillespie, G Yancey: 3 articles (11/2020 - 06/2012)
10.	Bonner, James A: 3 articles (06/2019 - 06/2012)

Related Diseases

1.	Mood Disorders (Mood Disorder) 01/01/1999 - "A number of studies now indicate that lithium has considerable efficacy in the prevention of suicide in patients with affective disorders, and accumulating evidence indicates that protein kinase C (PKC) and its substrates, in particular the myristoylated alanine-rich C kinase substrate (MARCKS), are primary targets of chronic lithium treatment. " 02/01/2002 - "To examine if the abnormalities observed in the PI signaling system of patients with affective disorders, reported in previous studies, are related to abnormalities in one or more of its components, we studied PKC, PI-PLC activity, the expression of their specific isozymes, and expression of myristoylated alanine-rich C-kinase substrate (MARCKS) in platelets obtained from 15 drug-free hospitalized patients with bipolar disorder and 15 with major depressive disorder (unipolar) and from 15 nonhospitalized normal control subjects. "
2.	Neuroblastoma 12/06/2017 - "We have previously reported that the MARCKS protein is involved in the MeHg toxicity to SH-SY5Y neuroblastoma and EA.hy926 vascular endothelial cell lines. " 05/01/2014 - "Because myristoylated alanine-rich C kinase substrate (MARCKS) plays an essential role in the differentiation and development of neuronal cells, we studied the alteration of MARCKS expression and phosphorylation in MeHg-induced neurotoxicity of neuroblastoma SH-SY5Y cells and in the rat brain. " 03/01/2001 - "The aim of this study was to investigate a possible role of the myristoylated alanine-rich C kinase substrate (MARCKS) in the mechanism of noradrenaline uptake and release in the human neuroblastoma cell line SH-SY5Y. " 03/01/2001 - "Overexpression of the myristoylated alanine-rich C kinase substrate decreases uptake and K(+)-evoked release of noradrenaline in the human neuroblastoma SH-SY5Y." 04/01/1999 - "We investigated the role of PKC down-regulation on phosphorylation of two PKC substrates, the 43 kDa growth-associated protein (GAP-43) and the myristoylated alanine-rich C-kinase substrate (MARCKS) in SK-N-SH human neuroblastoma cells. "
3.	Hepatocellular Carcinoma (Hepatoma) 03/01/2005 - "Comparison study of the expressions of myristoylated alanine-rich C kinase substrate in hepatocellular carcinoma, liver cirrhosis, chronic hepatitis, and normal liver." 06/15/1991 - "No significant stimulation of MARCKS protein phosphorylation was seen in four other insulin-sensitive cell lines, in which insulin is known to activate other protein serine/threonine kinases: HIRC-B, BC3H-1, 3T3-L1 adipocytes, and H35 rat hepatoma cells made to stably express the MARCKS protein. "
4.	Glioblastoma (Glioblastoma Multiforme) 06/01/2012 - "This study assessed whether myristoylated alanine-rich C-kinase substrate (MARCKS) can regulate glioblastoma multiforme (GBM) growth, radiation sensitivity, and clinical outcome. " 06/01/2019 - "Myristoylated alanine-rich C-kinase substrate effector domain phosphorylation regulates the growth and radiation sensitization of glioblastoma."
5.	Liver Cirrhosis (Hepatic Cirrhosis) 03/01/2005 - "Comparison study of the expressions of myristoylated alanine-rich C kinase substrate in hepatocellular carcinoma, liver cirrhosis, chronic hepatitis, and normal liver."

Related Drugs and Biologics

1.	Protein Kinase C
2.	Norepinephrine (Noradrenaline)
3.	Lithium
4.	Isoenzymes
5.	Proteins (Proteins, Gene)
6.	Phorbol Esters
7.	Myristoylated Alanine-Rich C Kinase Substrate
8.	Peptides (Polypeptides)
9.	Mucins
10.	Cytokines

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics
3.	Ligation