Cell Adhesion Molecule-1

A cell adhesion molecule that contains extracellular immunoglobulin V and C2 domains. It mediates homophilic and heterophilic cell-cell adhesion independently of calcium, and acts as a tumor suppressor in NON-SMALL-CELL LUNG CANCER (NSCLC) cells. Its interaction with NATURAL KILLER CELLS is important for their cytotoxicity and its expression by MAST CELLS plays a role in their interaction with neurons; it may also function in synapse assembly, nerve growth and differentiation.

Also Known As:

Networked: 423 relevant articles (6 outcomes, 55 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ito, Akihiko: 14 articles (01/2021 - 09/2003)
2.	Murakami, Yoshinori: 10 articles (05/2022 - 10/2004)
3.	Hagiyama, Man: 10 articles (01/2019 - 05/2008)
4.	Inoue, Takao: 7 articles (01/2019 - 01/2013)
5.	Morishita, Kazuhiro: 6 articles (01/2021 - 01/2012)
6.	Yoneshige, Azusa: 6 articles (11/2018 - 01/2015)
7.	Sasaki, Makoto: 6 articles (03/2011 - 04/2002)
8.	Cataldi, Fabio: 5 articles (01/2022 - 01/2018)
9.	Wakayama, Tomohiko: 5 articles (11/2018 - 09/2003)
10.	Joh, Takashi: 5 articles (03/2011 - 04/2002)

Related Diseases

1.	Neoplasms (Cancer) 04/01/2011 - "The aim of the present study was to investigate the methylation status and expression levels of cell adhesion molecule 1 (CADM1) in HCC; to elucidate its regulation mechanisms; and finally, to evaluate the potential predictive value for tumor recurrence. " 06/01/2023 - "Although the pathophysiological mechanism is not fully understood, a negative correlation between NORAD and intercellular cell adhesion molecule-1 (ICAM-1) has been shown in experimental models, but this situation has not been evaluated in terms of cancer. " 01/01/2023 - "By inducing the down-regulation of mucosal addressin cell adhesion molecule 1 (MAdCAM-1) in the ileum, post-ABX gut recolonization by Enterocloster species drove the emigration of enterotropic α4β7+CD4+ regulatory T 17 cells into the tumor. " 10/22/2022 - "Gene expression analysis revealed modest elevated lytic EBV gene transcription as well as the expression of the tumor suppressor cell adhesion molecule 1 (CADM1). " 06/21/2022 - "Despite the earlier identification of membrane-proximal cleavage of cell adhesion molecule 1 (CADM1) in cancers, the role of the membrane-bound fragment of CAMD1 (MF-CADM1) is yet to be clearly identified. "
2.	Inflammation (Inflammations) 01/01/2019 - "In addition, we observed that systemic inflammation was inhibited, manifested downregulation of plasma macrophage inflammatory protein-1α and intercellular cell adhesion molecule-1. " 07/01/2017 - "Nano-targeting of mucosal addressin cell adhesion molecule-1 identifies bowel inflammation foci in murine model." 04/01/2002 - "The expression of CCL21 in association with mucosal addressin cell adhesion molecule-1 in portal tracts in PSC may promote the recruitment and retention of CCR7(+) mucosal lymphocytes leading to the establishment of chronic portal inflammation and the expanded portal-associated lymphoid tissue. " 03/01/1999 - "Expression of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in acute and chronic inflammation." 05/03/2023 - "Mucosal Addressin Cell Adhesion Molecule 1 Expression Reflects Mucosal Inflammation and Subsequent Relapse in Patients with Ulcerative Colitis."
3.	Crohn Disease (Crohn's Disease) 11/01/2001 - "Involvement of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in the pathogenesis of granulomatous colitis in rats." 05/01/2002 - "Differential expression of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in ulcerative colitis and Crohn's disease." 02/01/2013 - "Effect of tumor necrosis factor-α blockade on mucosal addressin cell-adhesion molecule-1 in Crohn's disease." 01/01/2022 - "Long-Term Safety and Efficacy of the Anti-Mucosal Addressin Cell Adhesion Molecule-1 Monoclonal Antibody Ontamalimab (SHP647) for the Treatment of Crohn's Disease: The OPERA II Study." 01/01/2020 - "PF-00547659 is a monoclonal antibody against human mucosal addressin cell adhesion molecule-1 (MAdCAM-1) that prevents the binding of α4β7+ lymphocytes to MAdCAM-expressing sites in the gastrointestinal tract with high affinity and selectivity, and is being developed for the treatment of Crohn's disease (CD). "
4.	Necrosis 02/06/2021 - "Furthermore, pro-inflammatory atherosclerotic markers (tumour necrosis factor-alpha (TNF-ɑ), vascular cell adhesion molecule-1 (VCAM-1), and intercellular cell adhesion molecule-1 (ICAM-1)) expressions were increased significantly, and anti-inflammatory marker (interleukin-10 (IL-10)) was decreased significantly in the OB group compared to the Normal group. " 02/01/2019 - "the acute liver necrosis mouse model and LTβR pre-treatment were used to assess intestinal mucosal addressin cell adhesion molecule-1 (MAdCAM - 1) expression, cell apoptosis, IgA+ cells and secretory immunoglobulin A (SIgA). " 10/01/2004 - "Both the low-fat and the very-low-carbohydrate diets resulted in significant decreases in absolute concentrations of hsTNF-alpha (high-sensitivity tumour necrosis factor-alpha), hsIL-6 (high-sensitivity interleukin-6), hsCRP (high-sensitivity C-reactive protein) and sICAM-1 (soluble intercellular cell-adhesion molecule-1). " 05/01/2017 - "Although an exclusively local effect of vedolizumab could be expected based on the restricted presence of the α4β7-mucosal vascular addressin cell adhesion molecule 1 complex in the gut, past combined success with anti-tumour necrosis factor, and previous demonstration of α4β7 integrin in the joint, led to the expectation of a therapeutic efficacy in spondyloarthritis. " 05/01/2003 - "However, no differences were observed between both groups in C-reactive protein, interleukin 6, tumour necrosis factor-alpha, soluble type 2 tumour necrosis factor receptor, and soluble intercellular cell adhesion molecule-1. "
5.	Lupus Nephritis 01/01/2020 - "Radix Paeoniae Rubra Ameliorates Lupus Nephritis in Lupus-Like Symptoms of Mrl Mice by Reducing Intercellular Cell Adhesion Molecule-1, Vascular Cell Adhesion Molecule-1, and Platelet Endothelial Cell Adhesion Molecule-1 Expression." 09/01/2023 - "In the kidneys of mice with lupus nephritis, LP-CQPC02 can upregulate the expression of inhibitor of NF-κB (IκB-α), downregulate the expression of NF-κB, transforming growth factor-β1 (TGF-β1), vascular endothelial growth factor (VEGF), intercellular cell adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1). "

Related Drugs and Biologics

1.	Vascular Cell Adhesion Molecule-1 (Vascular Cell Adhesion Molecule 1)
2.	Integrins
3.	CEACAM1 Protein
4.	Monoclonal Antibodies
5.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
6.	Carcinoembryonic Antigen
7.	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)
8.	ontamalimab
9.	Interleukin-6 (Interleukin 6)
10.	Messenger RNA (mRNA)

Related Therapies and Procedures

1.	Resuscitation
2.	Therapeutics
3.	Transcutaneous Electric Nerve Stimulation (TENS)
4.	Aftercare (After-Treatment)
5.	Carbohydrate-Restricted Diet (Low Carbohydrate Diet)