Zinc Transporter 8

A zinc efflux transporter highly expressed by ISLET CELLS of the pancreas. It functions in the accumulation of zinc in intracellular vesicles and may be involved in INSULIN maturation and storage processes. Variations in the SLC30A8 gene are associated with susceptibility to DIABETES MELLITUS, TYPE 2.

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Networked: 148 relevant articles (4 outcomes, 22 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Bonifacio, Ezio: 7 articles (11/2021 - 01/2008)
2.	Knip, Mikael: 7 articles (01/2021 - 11/2010)
3.	Ludvigsson, Johnny: 7 articles (01/2021 - 08/2011)
4.	Vaziri-Sani, Fariba: 7 articles (12/2015 - 08/2011)
5.	Elding Larsson, Helena: 6 articles (01/2022 - 08/2014)
6.	Yu, Liping: 6 articles (05/2021 - 05/2011)
7.	Lernmark, Åke: 6 articles (01/2020 - 08/2011)
8.	Bingley, Polly J: 6 articles (01/2018 - 02/2012)
9.	Wenzlau, Janet M: 6 articles (10/2015 - 10/2010)
10.	Huang, Gan: 5 articles (01/2022 - 10/2010)

Related Diseases

1.	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 02/01/2011 - "The aim of this study was to evaluate the humoral autoreactivity to zinc transporter 8 (ZnT8) depending on the clinical phenotype of type 1 diabetes (T1D). " 01/01/2023 - "Pancreatic autoimmunity in the diagnosis of type 1 diabetes: Usefulness of anti-zinc transporter 8 antibody and proposed stepwise assessment." 12/01/2022 - "Zinc transporter 8 (ZnT8) is a major humoral target in human type 1 diabetes (T1D). " 12/01/2022 - "Zinc transporter 8 haploinsufficiency protects against beta cell dysfunction in type 1 diabetes by increasing mitochondrial respiration." 01/01/2022 - "Zinc transporter 8 antibody-mediated type 1 diabetes mellitus: A case report."
2.	Insulinoma 06/01/2014 - "Subjects were screened for autoantibodies to GAD (GADA), insulinoma-associated antigen-2 (IA-2A), and zinc-transporter 8 (ZnT8A). " 04/01/2013 - "We consecutively studied 6,156 European diabetic patients attending clinics within 5 years of diagnosis (age range, 30-70 years) examined cross-sectionally clinically and for GAD antibodies (GADA) and antibodies to insulinoma-associated antigen-2 (IA-2A) and zinc-transporter 8 (ZnT8A). " 01/01/2023 - "Distribution of autoantibodies to insulinoma-associated antigen-2 and zinc transporter 8 in type 1 diabetes and latent autoimmune diabetes: A nationwide, multicentre, cross-sectional study." 10/01/2016 - "Qualitative changes in antibody status on follow-up and progression rate to diabetes were analysed in 88 children followed from birth in the prospective BABYDIAB study who developed multiple autoantibodies against insulin (IAA), GAD (GADA), insulinoma-associated antigen-2 (IA-2A) and/or zinc transporter 8 (ZnT8A). " 11/01/2019 - "Autoantibodies against glutamic acid decarboxylase (GAD), insulinoma-associated protein-2 and zinc transporter 8 were measured by radioligand assay. "
3.	Genetic Risk Score 01/01/2019 - "Zinc Transporter 8 Autoantibodies (ZnT8A) and a Type 1 Diabetes Genetic Risk Score Can Exclude Individuals With Type 1 Diabetes From Inappropriate Genetic Testing for Monogenic Diabetes." 12/01/2019 - "We measured three islet autoantibodies (islet antigen 2, glutamic acid decarboxylase and zinc transporter 8) and generated a Type 1 diabetes genetic risk score in all children. " 12/01/2021 - "In this review, we use the timeline of the study to review the accompanying basic science developments which have facilitated improved prediction by genetic (HLA analysis through to genetic risk scores) and biochemical strategies (islet cell autoantibodies through to improved individual tests for antibodies to insulin, glutamate decarboxylase, the tyrosine phosphatase IA-2, zinc transporter 8 and tetraspanin 7). "
4.	Type 2 Diabetes Mellitus (MODY) 05/15/2012 - "Genomewide association studies have linked a polymorphism in the zinc transporter 8 (Znt8) gene to higher risk of developing type 2 diabetes. " 01/01/2011 - "Recent human genetic studies have revealed that common variants of the zinc transporter 8 (ZnT-8) gene are strongly associated with type 2 diabetes mellitus (T2DM). " 01/01/2023 - "The rare SLC30A8 mutation encoding a truncating p.Arg138* variant (R138X) in zinc transporter 8 (ZnT8) is associated with a 65% reduced risk for type 2 diabetes. " 11/01/2019 - "A rare loss-of-function allele p.Arg138* in SLC30A8 encoding the zinc transporter 8 (ZnT8), which is enriched in Western Finland, protects against type 2 diabetes (T2D). " 12/01/2017 - "The non-synonymous single nucleotide polymorphism (SNP) rs13266634 in human zinc transporter 8, ZnT8 (SLC30A8), leads to a R325 variant, which is associated with an increased risk of developing Type 2 Diabetes (T2D). "
5.	Diabetes Mellitus 01/01/2017 - "In patients with diabetes mellitus, GFAP autoantibody levels were increased in patients with either T1DM or T2DM, and were significantly associated with GAD65 autoantibodies but not zinc transporter 8 autoantibodies. " 07/20/2015 - "A bridging-type ELISA for measuring autoantibodies to zinc transporter 8 (ZnT8A) was assessed using samples from different forms of diabetes mellitus. " 10/15/2015 - "Diabetes mellitus is associated with disturbed zinc homeostasis and down-regulation of zinc transporter 8 (ZnT8); these changes contribute to the defective biosynthesis, storage, and secretion of insulin. " 07/20/2015 - "Bridging-type enzyme-linked immunoassay for zinc transporter 8 autoantibody measurements in adult patients with diabetes mellitus." 08/01/2014 - "The aim of this study was to explore whether islet cell antibodies (ICA) could be identified in children with newly onset diabetes mellitus but negative for autoantibodies against glutamic acid decarboxylase (GADA), islet antigen-2 (IA-2A), insulin (IAA), or any of the three variants with arginine (R), tryptophan (W), or glutamine (Q) at position 325 of the zinc transporter 8 (ZnT8A). "

Related Drugs and Biologics

1.	Autoantibodies
2.	Insulin (Novolin)
3.	Glutamate Decarboxylase (Decarboxylase, Glutamate)
4.	Antibodies
5.	Antigens
6.	Tyrosine (L-Tyrosine)
7.	Phosphoric Monoester Hydrolases (Phosphatases)
8.	Tetraspanins
9.	Biomarkers (Surrogate Marker)
10.	islet cell antibody