COP9 Signalosome Complex

A multiprotein complex that functions as a peptide hydrolase, or isopeptidase to cleave NEDD8 PROTEIN from the CULLIN and UBIQUITIN-PROTEIN LIGASES, controlling the activity of the ligases. It is highly conserved in eukaryotes and typically consists of 8 subunits (CSN 1-8 proteins). The COP9 signalosome was originally identified in plants, where it controls gene transcription in response to light.

Also Known As:

COP9 Signalosome (CSN); COP9 Signalosome Subunit 1; COP9 Signalosome Subunit 2; COP9 Signalosome Subunit 3; COP9 Signalosome Subunit 4; COP9 Signalosome Subunit 5; COP9 Signalosome Subunit 6; COP9 Signalosome Subunit 7A; COP9 Signalosome Subunit 7B; COP9 Signalosome Subunit 8; COP9 Signalsome; Constitutive Photomorphogenesis 9 Signalosome; Constitutive Photomorphogenesis 9 Signalsome; FUSCA Protein 11; G Protein Pathway Suppressor 1; Sgn3; Signalosome Subunit 3; Signalosome Complex, COP9; Signalsome, COP9; Subunit 3, Signalosome

Networked: 54 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Pei, Dong-Sheng: 4 articles (01/2019 - 08/2015)
2.	Fang, Lekun: 3 articles (01/2020 - 01/2015)
3.	Lee, Mong-Hong: 3 articles (01/2020 - 01/2015)
4.	Bernhagen, Jürgen: 3 articles (01/2019 - 06/2012)
5.	Choi, Hyun Ho: 2 articles (01/2020 - 01/2015)
6.	Chen, Cheng: 2 articles (01/2019 - 01/2019)
7.	Mao, Zun: 2 articles (01/2019 - 01/2019)
8.	Sang, Miao-Miao: 2 articles (01/2019 - 08/2015)
9.	Wang, Bin: 2 articles (01/2018 - 01/2017)
10.	Pardi, Ruggero: 2 articles (01/2017 - 05/2011)

Related Diseases

1.	Neoplasms (Cancer) 07/15/2023 - "As a key component of the COP9 signalosome complex, which participates in a variety of physiological processes, COPS3 is intimately related to multiple cancers. " 07/23/2022 - "Despite the understanding of the COP9 signalosome subunit 5 (CSN5) in tumor genesis, there is no conclusive evidence on its value to predict the survival and prognosis of digestive system tumor patients. " 01/01/2020 - "Background: CSN6, a subunit of the highly conserved constitutive photomorphogenesis 9 (COP9) signalosome (CSN), has been reported to be implicated in tumor progression in various kinds of malignant tumors. " 01/01/2020 - "The role of COP9 signalosome subunit 6 (CSN6) in regulating cancer stemness was evaluated by organoid formation and limited dilution analysis. " 01/01/2019 - "COP9 signalosome subunit 5 (CSN5) has been involved in the progression of diverse human cancers. "
2.	Melanoma (Melanoma, Malignant) 02/18/2021 - "This study aimed to investigate the roles of COP9 signalosome subunit 8 (COPS8) and its underlying mechanism in cutaneous melanoma. " 01/01/2021 - "As a critical subunit of the constitutive photomorphogenesis 9 (COP9) signalosome (CSN), CSN6 is upregulated in some human cancers and plays critical roles in tumorigenesis and progression, but its biological functions and molecular mechanisms in melanoma remain unknown. "
3.	Cardiovascular Diseases (Cardiovascular Disease) 01/01/2019 - "Role of the COP9 Signalosome (CSN) in Cardiovascular Diseases." 12/01/2022 - "Interestingly, two proteins directly linked to cardiovascular diseases (CVD) in in vitro and in vivo studies underwent deregulation: COP9 signalosome complex subunit 9 and thrombomodulin. "
4.	Hepatocellular Carcinoma (Hepatoma) 01/01/2020 - "CSN6, as a critical subunit of the constitutive photomorphogenesis 9 (COP9) signalosome (CSN), has been previously reported to be increased in various cancers; however, its effect in hepatocellular carcinoma (HCC) remains unknown, which is the aim of present study, in terms of its explore the expression and role of CSN6 in HCC. "
5.	Diarrhea 01/01/2020 - "We found the COP9 signalosome (CSN) conserved in multiple pathogens such as Leishmania, Trypanosoma, Toxoplasma, and used the severe diarrhea-causing Entamoeba histolytica to study its function in medically significant protozoa. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Thrombomodulin
3.	Ubiquitin
4.	Carrier Proteins (Binding Protein)
5.	Phosphotransferases (Kinase)
6.	Proteasome Endopeptidase Complex (Proteasome)
7.	Ubiquitin-Specific Proteases
8.	Interleukin-1 Receptor-Associated Kinases
9.	Lysosomal-Associated Membrane Protein 1
10.	Hepatocyte Nuclear Factor 4

Related Therapies and Procedures

1.	Therapeutics