NADPH Oxidase 5

An NADPH oxidase that contains four EF HANDS and is expressed primarily by SPERMATOCYTES and LYMPHOCYTES, as well as by endothelial cells. It functions as a calcium-dependent proton channel to generate SUPEROXIDES that regulate cell growth, APOPTOSIS; and PHYSIOLOGIC ANGIOGENESIS.

Also Known As:

Networked: 27 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Zalba, Guillermo: 3 articles (08/2021 - 10/2018)
2.	Cortés, Adriana: 2 articles (08/2021 - 11/2020)
3.	Marqués, Javier: 2 articles (08/2021 - 11/2020)
4.	Pejenaute, Álvaro: 2 articles (08/2021 - 11/2020)
5.	Akaike, Hidenori: 2 articles (08/2021 - 08/2019)
6.	Amemiya, Hidetake: 2 articles (08/2021 - 08/2019)
7.	Ashizawa, Naoki: 2 articles (08/2021 - 08/2019)
8.	Furuya, Shinji: 2 articles (08/2021 - 08/2019)
9.	Hosomura, Naohiro: 2 articles (08/2021 - 08/2019)
10.	Ichikawa, Daisuke: 2 articles (08/2021 - 08/2019)

Related Diseases

1.	Neoplasms (Cancer) 12/01/2013 - "However, because immunological tools are lacking, knowledge of the role of Nox5 in tumor biology has been limited; the expression of Nox5 protein across tumors and normal tissues is essentially unknown. " 05/15/2020 - "This study analyzed the expression of NADPH oxidase 5 in lymphoma tissue according to the degree of tumor aggressiveness. " 12/01/2017 - "NADPH oxidase 5 (NOX5) generated reactive oxygen species (ROS) have been implicated in signaling cascades that regulate cancer cell proliferation. " 12/01/2013 - "Here, we report the characterization and use of a mouse monoclonal antibody against a recombinant Nox5 protein (bp 600-746) for expression profiling of Nox5 in human tumors by tissue microarray analysis. " 12/01/2013 - "Reactive oxygen species generated by NADPH oxidase 5 (Nox5) have been implicated in physiological and pathophysiological signaling pathways, including cancer development and progression. "
2.	Lymphoma (Lymphomas) 05/15/2020 - "Aggressive lymphomas overexpress NOX5 protein. " 05/15/2020 - "NADPH Oxidase 5 upregulation is associated with lymphoma aggressiveness." 05/15/2020 - "This study analyzed the expression of NADPH oxidase 5 in lymphoma tissue according to the degree of tumor aggressiveness. "
3.	Atherosclerosis 01/01/2019 - "Monocyte-derived macrophages express functional NADPH oxidase 5 (Nox5) that contributes to oxidative stress in atherogenesis. " 05/22/2015 - "Human monocytes and macrophages express NADPH oxidase 5; a potential source of reactive oxygen species in atherosclerosis." 01/01/2022 - "Endothelial reactive oxygen-forming NADPH oxidase 5 is a possible player in diabetic aortic aneurysm but not atherosclerosis." 11/01/2020 - "NADPH oxidase 5 has emerged as a new player in oxidative stress-mediated endothelial alterations, involved in the pathophysiology of hypertension, diabetes, atherosclerosis, myocardial infarction and stroke. " 01/01/2019 - "Histone Acetyltransferase-Dependent Pathways Mediate Upregulation of NADPH Oxidase 5 in Human Macrophages under Inflammatory Conditions: A Potential Mechanism of Reactive Oxygen Species Overproduction in Atherosclerosis."
4.	Stroke (Strokes) 08/20/2021 - "The NADPH oxidase 5 (NOX5) isoform is absent in rodents, and although little is known about the role it may play in disrupting the BBB, it has recently been implicated in experimental stroke. " 11/01/2020 - "NADPH oxidase 5 has emerged as a new player in oxidative stress-mediated endothelial alterations, involved in the pathophysiology of hypertension, diabetes, atherosclerosis, myocardial infarction and stroke. "
5.	Melanoma (Melanoma, Malignant) 12/01/2013 - "Using our novel antibody, we also report the detection of endogenous Nox5 protein in human UACC-257 melanoma cells. " 12/01/2017 - "NADPH oxidase 5 (NOX5)-induced reactive oxygen signaling modulates normoxic HIF-1α and p27Kip1 expression in malignant melanoma and other human tumors."

Related Drugs and Biologics

1.	Reactive Oxygen Species (Oxygen Radicals)
2.	Oxygen (Dioxygen)
3.	Cisplatin (Platino)
4.	Histone Acetyltransferases (Histone Acetyltransferase)
5.	Toll-Like Receptors (Toll-Like Receptor)
6.	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)
7.	Activated-Leukocyte Cell Adhesion Molecule (Neurolin)
8.	Protein Isoforms (Isoforms)
9.	Complementary DNA (cDNA)
10.	Superoxides (Superoxide)