Solute Carrier Organic Anion Transporter Family Member 1B3

A sodium-independent organic anion transporter that functions in the uptake of various drugs and endogenous compounds including ESTRADIOL; TAUROCHOLATE; LEUKOTRIENE C4; and METHOTREXATE. It also functions in clearing BILE ACIDS and organic anions from the liver. Mutations in the SLCO1B3 gene are associated with Rotor Type HYPERBILIRUBINEMIA.

Also Known As:

Networked: 8 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Lee, Wooin: 2 articles (01/2013 - 01/2008)
2.	Abe, Takaaki: 2 articles (01/2008 - 10/2007)
3.	Katayose, Yu: 2 articles (01/2008 - 10/2007)
4.	Muto, Mitsuhisa: 2 articles (01/2008 - 10/2007)
5.	Onogawa, Tohru: 2 articles (01/2008 - 10/2007)
6.	Rikiyama, Toshiki: 2 articles (01/2008 - 10/2007)
7.	Unno, Michiaki: 2 articles (01/2008 - 10/2007)
8.	Du, Yan: 1 article (06/2022)
9.	Huang, Jiafeng: 1 article (06/2022)
10.	Huang, Yutang: 1 article (06/2022)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2020 - "The Emerging Role of the SLCO1B3 Protein in Cancer Resistance." 04/05/2016 - "GPR56, LY6G6D/F and SLCO1B3 protein expression was significantly correlated with the proximal tumor location and with expression of mismatch repair genes. " 01/07/2013 - "However, a detailed investigation on the expression and function of OATP1B3 protein in cancer has been lacking. " 01/01/2008 - "Immunohistochemistry was used to assess OATP1B3 protein expression in paraffinized colon tumor tissue microarrays. " 01/01/2020 - "In this review, we focus on the emerging roles of SLCO1B3 protein in the development of cancer chemotherapy resistance and briefly discuss the mechanisms of resistance. "
2.	Hyperbilirubinemia 05/01/2018 - "RESULTS A nonsynonymous mutation at ovine Chr3:193,691,195, which generated a glycine-to-arginine amino acid change within the predicted Slco1b3 protein, was significantly associated with hyperbilirubinemia and predicted to be deleterious. "
3.	Gastrointestinal Neoplasms (Gastrointestinal Cancer) 01/01/2008 - "Because the human liver-specific organic anion transporter-2 (LST-2/OATP8/OATP1B3) is expressed in gastrointestinal cancers and might transport bile acids to the intracellular space, we studied the molecular mechanisms by which bile acids induce the transcription of COX-2, and the role of LST-2 in colonic cell lines. "
4.	Carcinoma (Carcinomatosis) 10/01/2007 - "Human liver-specific organic anion transporter-2 (LST-2/OATP8/SLCO1B3) has been demonstrated to be expressed in various gastrointestinal carcinomas and also to play pivotal roles in the uptake of a wide variety of both endogenous and exogenous anionic compounds, including bile acids, conjugated steroids and hormones, into hepatocytes in the human liver. "
5.	Breast Neoplasms (Breast Cancer) 10/01/2007 - "Human liver-specific organic anion transporter-2 is a potent prognostic factor for human breast carcinoma."

Related Drugs and Biologics

1.	Bile Acids and Salts (Bile Acids)
2.	Steroids
3.	Peptides (Polypeptides)
4.	Hormones (Hormone)
5.	Glycine (Aminoacetic Acid)
6.	Arginine (L-Arginine)
7.	Anions
8.	Amino Acids

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)