Human liver-specific organic anion transporter-2 is a potent prognostic factor for human breast carcinoma.

Abstract

Human liver-specific organic anion transporter-2 (LST-2/OATP8/SLCO1B3) has been demonstrated to be expressed in various gastrointestinal carcinomas and also to play pivotal roles in the uptake of a wide variety of both endogenous and exogenous anionic compounds, including bile acids, conjugated steroids and hormones, into hepatocytes in the human liver. However, the biological significance of LST-2 in human carcinomas remains unknown. In the present study, we examined the expression of LST-2 in 102 cases of breast carcinoma using immunohistochemistry and correlated the findings with various clinicopathological parameters in order to examine the possible biological and clinical significance of LST-2. LST-2 immunoreactivity was detected in 51 cases (50.0%); of these 51 positive cases, LST-2 immunoreactivity was inversely correlated with tumor size (P = 0.0289). In addition, LST-2 immunoreactivity was significantly associated with a decreased risk of recurrence and improved prognosis by both univariate (P = 0.02 and P = 0.01) and multivariate (P = 0.03 and P = 0.01) analyses. In the estrogen receptor-positive groups, the LST-2-positive patients showed good prognoses. Considering that LST-2 transports estrone-3-sulfate, these results suggest that LST-2 overexpression is associated with a hormone-dependent growth mechanism of the breast cancer. The results of our present study demonstrate that LST-2 immunoreactivity is a potent prognostic factor in human breast cancer.

• Authors: Mitsuhisa Muto, Tohru Onogawa, Takashi Suzuki, Takanori Ishida, Toshiki Rikiyama, Yu Katayose, Noriaki Ohuchi, Hironobu Sasano, Takaaki Abe, Michiaki Unno
• Journal: Cancer science (Cancer Sci) Vol. 98 Issue 10 Pg. 1570-6 (Oct 2007) ISSN: 1347-9032 [Print] England
• PMID: 17760952 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Organic Anion Transporters, Sodium-Independent
• Receptors, Estrogen
• SLC22A7 protein, human
• SLCO1B3 protein, human
• Solute Carrier Organic Anion Transporter Family Member 1B3

Topics

• Adult
• Aged
• Breast Neoplasms (metabolism, pathology)
• Carcinoma, Ductal, Breast (metabolism, pathology)
• Humans
• Immunoenzyme Techniques
• Liver (metabolism)
• Middle Aged
• Neoplasm Recurrence, Local
• Neoplasm Staging
• Organic Anion Transporters, Sodium-Independent (metabolism)
• Prognosis
• Receptors, Estrogen (metabolism)
• Solute Carrier Organic Anion Transporter Family Member 1B3
• Survival Rate