Aldo-Keto Reductases

A family of NADPH-dependent oxidoreductases that reduce carbonyl substrates including sugar-aldehydes, KETOSTEROIDS; keto-prostaglandins, and QUINONES. They are monomers of approximately 37 KDa and are characterized by a parallel beta-8 (BETA SHEET)-alpha 8 (ALPHA HELICES)-barrel structure that contains the NADP binding site. This conformation favors aromatic and apolar substrates.

Also Known As:

Networked: 299 relevant articles (4 outcomes, 25 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Endo, Satoshi: 29 articles (01/2022 - 03/2009)
2.	Matsunaga, Toshiyuki: 26 articles (01/2022 - 03/2009)
3.	Hara, Akira: 23 articles (01/2018 - 03/2009)
4.	El-Kabbani, Ossama: 21 articles (11/2017 - 03/2009)
5.	Penning, Trevor M: 16 articles (01/2021 - 07/2002)
6.	Cao, Deliang: 14 articles (01/2022 - 09/2006)
7.	Soda, Midori: 14 articles (11/2017 - 07/2009)
8.	Ikari, Akira: 12 articles (01/2022 - 07/2014)
9.	Toyooka, Naoki: 10 articles (09/2021 - 02/2012)
10.	Rižner, Tea Lanišnik: 7 articles (02/2022 - 01/2012)

Related Diseases

1.	Neoplasm Metastasis (Metastasis) 01/01/2019 - "We identify the aldo-keto reductase AKR1B10 as a metastasis enhancer that has little impact on primary tumour growth or dissemination but promotes effective tumour growth in secondary sites and, in human disease, is associated with an increased risk of distant metastatic relapse. " 01/01/2018 - "Methods: GEO data analyses and IHC analyses were performed to identify that the expression level of AKR1C1, a member of human aldo-keto reductase family, was highly elevated in patients with metastasis or metastatic foci of NSCLC patients. " 01/01/2022 - "Aldo-keto reductase family 1 member C1 (AKR1C1) plays an important role in cancer cell proliferation and metastasis, and has gained attention as an anticancer drug target. " 01/01/2019 - "AKR1B10 (Aldo-keto reductase family 1 B10) promotes brain metastasis of lung cancer cells in a multi-organ microfluidic chip model." 10/01/2018 - "Aldo-keto reductase 1B10 (AKR1B10) is upregulated in breast cancer and promotes tumor growth and metastasis. "
2.	Lung Neoplasms (Lung Cancer) 01/01/2023 - "Aldo-keto reductase family 1 B10 (AKR1B10) was recently found to be elevated in lung cancer BM. " 03/01/2012 - "AKR1B10 (aldo-keto reductase 1B10) is overexpressed in liver and lung cancer, and plays a critical role in tumour development and progression through promoting lipogenesis and eliminating cytotoxic carbonyls. " 01/01/2019 - "AKR1B10 (Aldo-keto reductase family 1 B10) promotes brain metastasis of lung cancer cells in a multi-organ microfluidic chip model." 01/01/2019 - "The chip was verified by lung cancer cell lines with differing metastatic abilities and then applied for the BM research where we first demonstrated that the protein expression of Aldo-keto reductase family 1 B10 (AKR1B10) was significantly elevated in lung cancer BM. " 07/15/2014 - "Exposure to 9,10-phenanthrenequinone accelerates malignant progression of lung cancer cells through up-regulation of aldo-keto reductase 1B10."
3.	Neoplasms (Cancer) 11/08/2023 - "AKR1B1 and AKR1B10 are important members of aldo-keto reductase family which plays a significant role in cancer progression by modulating cellular metabolism. " 10/01/2023 - "RNF152-overexpressed tumor cells exhibited a significantly lower level of Aldo-Keto reductase family 1 member 10 (AKR1B10), whereas up-regulation of IRAK1 restored the expression of AKR1B10 in RNF152-overexpressed cells. " 02/22/2023 - "The human aldo-keto reductase (AKRs) superfamily is involved in the development of various tumors. " 01/01/2023 - "Development of Biaryl-Containing Aldo-Keto Reductase 1C3 (AKR1C3) Inhibitors for Reversing AKR1C3-Mediated Drug Resistance in Cancer Treatment." 08/11/2022 - "As a crucial target which is overexpressed in a variety of cancers, aldo-keto reductase 1C3 (AKR1C3) confers chemotherapeutic resistance to many clinical agents. "
4.	Neuroblastoma 01/01/2013 - "Aldo-keto reductases mediate constitutive and inducible protection against aldehyde toxicity in human neuroblastoma SH-SY5Y cells." 09/07/2007 - "Synthesis and catabolism of gamma-hydroxybutyrate in SH-SY5Y human neuroblastoma cells: role of the aldo-keto reductase AKR7A2."
5.	Hepatocellular Carcinoma (Hepatoma) 03/01/2021 - "The in vitro study has verified that aldo-keto reductase family1, member10 plays an important role in AFB1-induced hepatotoxicity and Se-mediated detoxification of AFB1 in a chicken leghorn male hepatoma cells. " 01/01/2021 - "Regulation Network and Prognostic Significance of Aldo-Keto Reductase (AKR) Superfamily Genes in Hepatocellular Carcinoma." 10/20/2020 - "[Aldo-keto reductase family 1 B10 participates in the regulation of hepatoma cell cycle through p27/p-Rb signaling pathway]." 12/01/2018 - "Prognostic Significance of 14-3-3ε, Aldo-keto Reductase Family 1 B10 and Metallothionein-1 in Hepatocellular Carcinoma." 10/09/2018 - "Correction: Regulation of Aldo-keto-reductase family 1 B10 by 14-3-3ε and their prognostic impact of hepatocellular carcinoma."

Related Drugs and Biologics

1.	Cisplatin (Platino)
2.	Aldehydes
3.	Hormones (Hormone)
4.	Hydroxysteroid Dehydrogenases
5.	prostaglandin-F synthase
6.	Enzymes
7.	Proteins (Proteins, Gene)
8.	Anthracyclines
9.	Phosphates (Orthophosphate)
10.	Aldehyde Reductase (Aldose Reductase)

Related Therapies and Procedures

1.	Therapeutics
2.	Castration
3.	Drug Therapy (Chemotherapy)
4.	Aftercare (After-Treatment)
5.	Chinese Traditional Medicine (Traditional Chinese Medicine)