Discs Large Homolog 1 Protein

A signaling adaptor protein that contains three PDZ DOMAINS; an SH3 DOMAIN; and a GUANYLATE KINASE-like C-terminal region. It has an essential role in animal development and recruits ion channels, receptors, and signaling molecules to discrete plasma membrane regions of polarized cells in the HEART ATRIA MYOCARDIUM. It functions in the assembly of ADHERENS JUNCTIONS and regulation of CELL PROLIFERATION; synaptogenesis, LYMPHOCYTE ACTIVATION; and controls expression of KV4 POTASSIUM CHANNELS to regulate excitability of CARDIAC MYOCYTES.

Also Known As:

Networked: 11 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Nishikawa, Toru: 3 articles (12/2017 - 09/2008)
2.	Yamamoto, Naoki: 3 articles (12/2017 - 09/2008)
3.	Chen, Wubiao: 2 articles (01/2021 - 01/2020)
4.	Dai, Zhun: 2 articles (01/2021 - 01/2020)
5.	Fu, Jiawu: 2 articles (01/2021 - 01/2020)
6.	He, Bin: 2 articles (01/2021 - 01/2020)
7.	Li, You: 2 articles (01/2021 - 01/2020)
8.	Liang, Chunmei: 2 articles (01/2021 - 01/2020)
9.	Lin, Juda: 2 articles (01/2021 - 01/2020)
10.	Lin, Zhixiong: 2 articles (01/2021 - 01/2020)

Related Diseases

1.	Schizophrenia (Dementia Praecox) 01/01/2023 - "Our previous study data suggested that the synapse-associated protein 97 (SAP97) rs3915512 polymorphism is significantly related to clinical performance in schizophrenia. " 01/01/2021 - "This study tested whether synapse-associated protein 97 (SAP97), a reasonable candidate gene for schizophrenia, is related to orbitofrontal-striatal-thalamic connection changes in first-episode schizophrenia (FES) patients and the clinical performance of schizophrenic patients by affecting this integrity. " 01/01/2020 - "Our previous study suggested that the synapse-associated protein 97 (SAP97) gene rs3915512 polymorphism may influence neurocognition in schizophrenia patients. " 01/01/2023 - "Genetic contribution of synapse-associated protein 97 to cerebellar functional connectivity changes in first-episode schizophrenia." 01/01/2021 - "Genetic Contribution of Synapse-Associated Protein 97 to Orbitofrontal-Striatal-Thalamic Circuitry Connectivity Changes in First-Episode Schizophrenia."
2.	Herpes Zoster 07/31/2012 - "We showed that the conserved cytoplasmic tail of the IgG BCR, which contains a putative PDZ (postsynaptic density 95/disc large/zona occludens 1)-binding motif, associated with synapse-associated protein 97 (SAP97), a PDZ domain-containing scaffolding molecule that is involved in controlling receptor density and signal strength at neuronal synapses. " 11/01/2008 - "Using surface plasmon resonance, we studied the interaction of members of all four MAGUK subfamilies--synapse-associated protein 97 (SAP97), calcium/calmodulin-dependent serine protein kinase (CASK), membrane palmitoylated protein 2 (MPP2), and zona occludens (ZO) 1--and calmodulin to determine interaction affinities and localize the binding site. "
3.	Cardiomyopathies (Cardiomyopathy) 05/01/2019 - "IF for two proteins recently investigated in desmosomal arrhythmogenic cardiomyopathy (ACM), synapse-associated protein 97 and glycogen synthase kinase-3 beta, showed a distinct distributional pattern in comparison to desmosomal ACM. "
4.	Ischemia 11/15/2012 - "Induced ischemia rapidly increased glycosylation of Panx1, resulting in increased trafficking to the plasma membrane as well as increased interaction with synapse-associated protein 97. "
5.	Alzheimer Disease (Alzheimer's Disease) 11/01/2010 - "Interfering with the ADAM10/synapse-associated protein 97 complex for 2 weeks by means of a cell-permeable peptide strategy is sufficient to shift the metabolism of the amyloid precursor protein towards amyloidogenesis and allows the reproduction of initial phases of sporadic Alzheimer's disease. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Ionotropic Glutamate Receptors
3.	Glutamate Receptors (Glutamate Receptor)
4.	N-Methylaspartate (NMDA)
5.	Serine (L-Serine)
6.	Protein Kinases (Protein Kinase)
7.	Peptides (Polypeptides)
8.	Immunoglobulin G (IgG)
9.	Glycogen Synthase (Synthase I)
10.	Calmodulin (Calcium-Dependent Activator Protein)