Zinc Finger E-box Binding Homeobox 2

A transcription factor that consists of 8 CYS2-HIS2 ZINC FINGERS flanking a central HOMEOBOX. It binds to the 5'-CACCT-3' DNA sequence located within E-BOX ELEMENTS of many genes essential for embryonic growth and development and regulates their activity; it represses transcription of the E-CADHERIN gene. Mutations in the ZEB2 gene are associated with MOWAT-WILSON SYNDROME.

Also Known As:

Smad-Interacting Protein 1; Zeb2 Transcription Factor; Zinc Finger E-box Binding Homeobox 2 Protein; Smad Interacting Protein 1; Transcription Factor, Zeb2; Zinc Finger E box Binding Homeobox 2; Zinc Finger E box Binding Homeobox 2 Protein

Networked: 99 relevant articles (0 outcomes, 13 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Transcription Factors: 38804
    - Repressor Proteins: 30
      - Zinc Finger E-box Binding Homeobox 2: 99
        human ZEB2 protein
        mouse ZEB2 protein
        rat Zeb2 protein
  - DNA-Binding Proteins: 2009
    - Homeodomain Proteins: 350
      - Zinc Finger E-box Binding Homeobox 2: 99
        human ZEB2 protein
        mouse ZEB2 protein
        rat Zeb2 protein
    - Repressor Proteins: 30
      - Zinc Finger E-box Binding Homeobox 2: 99
        human ZEB2 protein
        mouse ZEB2 protein
        rat Zeb2 protein

Experts

1.	Huylebroeck, Danny: 4 articles (01/2021 - 04/2008)
2.	Menon, Ram K: 3 articles (01/2019 - 10/2010)
3.	Haigh, Jody J: 2 articles (01/2021 - 01/2020)
4.	Mukhi, Dhanunjay: 2 articles (11/2019 - 01/2019)
5.	Nakuluri, Krishnamurthy: 2 articles (11/2019 - 01/2019)
6.	Nishad, Rajkishor: 2 articles (11/2019 - 01/2019)
7.	Zhang, Zhen: 2 articles (05/2019 - 06/2015)
8.	Saleem, Moin A: 2 articles (01/2019 - 01/2016)
9.	Kumar, P Anil: 2 articles (01/2016 - 10/2010)
10.	Chen, Xiaobing: 2 articles (08/2010 - 04/2010)

Related Diseases

1.	Glioma (Gliomas) 01/01/2012 - "The aim of the present study was to analyze the expression of Zinc finger E-box Binding homeobox 2 (ZEB2) in glioma and to explore the molecular mechanisms of ZEB2 that regulate cell proliferation, migration, invasion, and apoptosis. " 04/01/2010 - "In this study, we identified the important role of Smad interacting protein 1 (SIP1; also known as ZEB2) in glioma. " 04/01/2010 - "Identification of the role of Smad interacting protein 1 (SIP1) in glioma." 01/01/2020 - "In addition, zinc finger E-box binding homeobox 2 (ZEB2) was demonstrated to be a direct target of miR-769-3p in glioma cells using a luciferase assay. " 09/30/2022 - "miR-637 can target 21 protein-coding genes, which are involved in the regulation of cell growth, cell cycle, cell proliferation, epithelial-mesenchymal transition (EMT), cancer cell invasion and metastasis, etc. In glioma, the transcription factor ZEB2 can bind to the miR-637 promoter region and inhibit miR-637 expression. "
2.	Neoplasms (Cancer) 12/01/2022 - "In summary, our results demonstrate that ZFP36L1 suppresses EMT inliver cancer cells by down-regulating the expression of EMT-inducing transcription factor, ZEB2. " 01/01/2018 - "We also found that SOX2OT could regulate zinc finger E-box-binding homeobox 2 (a target of miR-132) expression, which played crucial roles in tumor cell proliferation and invasion. " 10/01/2014 - "Furthermore, we identified zinc finger E-box binding homeobox 2 (ZEB2) as a target of miR-141 and miR-141 functioned as a tumor suppressor via ZEB2 targeting in HCC. " 04/01/2013 - "Smad interacting protein 1 (SIP1) is an epithelial-mesenchymal transition (EMT)-inducible gene that plays a key role in tumor progression in various cancers. " 06/01/2012 - "Knockdown of LEF1 inhibited the expression of Slug and Zinc finger E-box-binding homeobox 2 (ZEB2) and markedly attenuated HGF-induced tumor migration and invasion. "
3.	Lung Neoplasms (Lung Cancer) 04/01/2018 - "The objective of the present study was to identify the function of a newly identified lncRNA zinc finger E-box-binding homeobox 2 antisense RNA 1 (ZEB2-AS1) in human lung cancer. " 06/01/2019 - "Studies have shown that long noncoding RNA Zinc finger E-box-binding homeobox 2 antisense RNA 1 (ZEB2-AS1) is involved in the progression of lung cancer, bladder cancer, and hepatocellular carcinoma. "
4.	Urinary Bladder Neoplasms (Bladder Cancer) 12/01/2017 - "The aim of this study was to explore the role of lncRNA zinc finger E-box binding homeobox 2 antisense RNA 1 (ZEB2-AS1), as a new tumor-associated lncRNA, in bladder cancer (BC) pathogenesis. " 06/01/2019 - "Studies have shown that long noncoding RNA Zinc finger E-box-binding homeobox 2 antisense RNA 1 (ZEB2-AS1) is involved in the progression of lung cancer, bladder cancer, and hepatocellular carcinoma. "
5.	Mowat-Wilson syndrome 01/02/2023 - "Background: Mowat-Wilson syndrome (MWS) is extremely rare multisystemic autosomal dominant disorder caused by mutations in the Zinc Finger E-Box Binding Homeobox 2 (ZEB2) gene. " 09/01/2020 - "Mowat-Wilson syndrome (MWS) is a multiorgan system disorder caused by ZEB2 (zinc finger E-box-binding homeobox 2) mutations or deletions. " 01/01/2019 - "Mowat-Wilson syndrome (MWS) is a complex developmental syndrome caused by heterozygous mutations in the Zinc finger E-box-binding homeobox 2 gene (ZEB2). " 12/01/2017 - "Mowat-Wilson syndrome (MWS) is a disorder caused by mutations or deletions of the zinc finger E-box-binding homeobox 2 (ZEB2) gene. " 01/01/2014 - "A loss of function of SIP1 (Smad interacting protein 1) in the mouse as well as in human of Mowat-Wilson syndrome results in severe and multiple defects in neural tissue development, especially in the brain. "

Related Drugs and Biologics

1.	Long Noncoding RNA
2.	Antisense RNA (Anti-Sense RNA)
3.	Cadherins (E-Cadherin)
4.	Transcription Factors (Transcription Factor)
5.	Proteins (Proteins, Gene)
6.	MicroRNAs (MicroRNA)
7.	Zinc Finger E-box-Binding Homeobox 1
8.	Transforming Growth Factors (Transforming Growth Factor)
9.	Catenins
10.	Homeodomain Proteins (Proteins, Homeobox)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)