MiR-141 targets ZEB2 to suppress HCC progression.

Abstract

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths worldwide. Increasing evidence suggests that microRNAs (miRNAs) are associated with HCC tumorigenesis. The present study was designed to define the role of miR-141 in HCC. The expression of miR-141 was significantly decreased in four HCC cell lines. Overexpression of miR-141 suppressed both the growth and the motility of HCC cells. Furthermore, we identified zinc finger E-box binding homeobox 2 (ZEB2) as a target of miR-141 and miR-141 functioned as a tumor suppressor via ZEB2 targeting in HCC. These data provide a novel potential therapeutic target for HCC treatment.

• Authors: Shi-Min Wu, Hong-Wu Ai, Ding-Yu Zhang, Xiao-Qun Han, Qin Pan, Feng-Ling Luo, Xiao-Lian Zhang
• Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine (Tumour Biol) Vol. 35 Issue 10 Pg. 9993-7 (Oct 2014) ISSN: 1423-0380 [Electronic] Netherlands
• PMID: 25008569 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Homeodomain Proteins
• MIRN141 microRNA, human
• MicroRNAs
• Repressor Proteins
• ZEB2 protein, human
• Zinc Finger E-box Binding Homeobox 2

Topics

• Blotting, Western
• Carcinoma, Hepatocellular (genetics, metabolism, pathology)
• Cell Line, Tumor
• Disease Progression
• Gene Expression Regulation, Neoplastic (physiology)
• Genes, Tumor Suppressor
• Homeodomain Proteins (biosynthesis, genetics)
• Humans
• Liver Neoplasms (genetics, metabolism, pathology)
• MicroRNAs (genetics, metabolism)
• Repressor Proteins (biosynthesis, genetics)
• Reverse Transcriptase Polymerase Chain Reaction
• Zinc Finger E-box Binding Homeobox 2