Subfamily D ATP Binding Cassette Transporter

A sub-family of ATP-binding cassette transporters that localize to the membranes of PEROXISOMES; ENDOPLASMIC RETICULUM; and LYSOSOMES. Members contain a transmembrane domain in their N-terminal half and generally function as homodimers in the transport of LIPIDS; BILE ACIDS; and VITAMIN B12. Mutations in some ABCD transporter genes are associated with PEROXISOMAL DISORDERS.

Also Known As:

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Hlaváč, Viktor: 1 article (10/2015)
2.	Souček, Pavel: 1 article (10/2015)
3.	Jang, Jiho: 1 article (01/2013)
4.	Kim, Dong-Wook: 1 article (01/2013)
5.	Kim, Han-Soo: 1 article (01/2013)
6.	Lee, Dongjin R: 1 article (01/2013)
7.	Lee, Hyunji: 1 article (01/2013)
8.	Lee, Jae Souk: 1 article (01/2013)
9.	Park, Chul-Yong: 1 article (01/2013)
10.	Yoo, Jeong-Eun: 1 article (01/2013)

Related Diseases

1.	Adrenoleukodystrophy (Adrenoleukodystrophy, X-Linked) 03/11/2011 - "X-linked adrenoleukodystrophy (X-ALD) is a neurodegenerative disorder caused by mutations in the ABCD1 gene, which encodes a peroxisomal member of the ATP-binding cassette (ABC) transporter subfamily D called ALDP. " 06/15/2011 - "When expressed in tobacco epidermal cells, the mammalian ABCD proteins ALDP (adrenoleukodystrophy protein), ALDR (adrenoleukodystrophy-related protein) and PMP70 (70 kDa peroxisomal membrane protein) targeted faithfully to peroxisomes and P70R (PMP70-related protein) targeted to the ER (endoplasmic reticulum), as in the native host. " 01/01/2013 - "X-linked adrenoleukodystrophy (X-ALD) is a peroxisomal disorder caused by mutations in the ABCD1 gene that encodes the peroxisomal ATP-binding cassette (ABC) transporter subfamily D member 1 protein (ABCD1), which is referred to as the adrenoleukodystrophy protein (ALDP). "
2.	Peroxisomal Disorders (Peroxisomal Disorder) 10/01/2015 - "ABCD transporters play a role in transport of lipids, bile acids and vitamin B12 and associate with peroxisomal disorders. " 01/01/2013 - "X-linked adrenoleukodystrophy (X-ALD) is a peroxisomal disorder caused by mutations in the ABCD1 gene that encodes the peroxisomal ATP-binding cassette (ABC) transporter subfamily D member 1 protein (ABCD1), which is referred to as the adrenoleukodystrophy protein (ALDP). "
3.	Carcinogenesis 10/01/2015 - "The role of ABCD transporters in tumour growth has not been studied in detail, but there is some evidence that ABCDs levels differ between undifferentiated stem or tumour cells and differentiated cells suggesting a possible link to tumorigenesis. "
4.	Neurodegenerative Diseases (Neurodegenerative Disease) 03/11/2011 - "X-linked adrenoleukodystrophy (X-ALD) is a neurodegenerative disorder caused by mutations in the ABCD1 gene, which encodes a peroxisomal member of the ATP-binding cassette (ABC) transporter subfamily D called ALDP. "
5.	Neoplasms (Cancer) 10/01/2015 - "In this mini-review, we discuss the available information about the role of ABCD transporters in cancer. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Adenosine Triphosphate (ATP)
3.	Member 1 Subfamily D ATP Binding Cassette Transporter
4.	Vitamin B 12 (Cyanocobalamin)
5.	Membrane Proteins (Integral Membrane Proteins)
6.	Lipids
7.	Bile Acids and Salts (Bile Acids)