TWEAK Receptor

A receptor for TWEAK cytokine that is highly expressed by cells in the heart, placenta, and kidney. It plays a role in ANGIOGENESIS and the proliferation of endothelial cells; it may also modulate cellular adhesion to the extracellular matrix.

Also Known As:

CD266 Antigen; Fn14 Receptor; Fn14 TWEAK Receptor; TNF Receptor Superfamily Member 12A; TWEAK Receptor Fn14; TWEAKR; Tumor Necrosis Factor Receptor Superfamily, Member 12A; Tumor Necrosis Factor-like Weak Inducer of Apoptosis Receptor; Antigen, CD266; Fn14, TWEAK Receptor; Receptor Fn14, TWEAK; Receptor, Fn14; Receptor, Fn14 TWEAK; Receptor, TWEAK; TWEAK Receptor, Fn14; Tumor Necrosis Factor like Weak Inducer of Apoptosis Receptor

Networked: 91 relevant articles (1 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - Immunologic Receptors: 9
        Cytokine Receptors: 1620
        Tumor Necrosis Factor Receptors: 3685
        TWEAK Receptor: 91
        human TNFRSF12A protein
        mouse Tnfrsf12a protein
        rat Tnfrsf12a protein

Experts

1.	Burkly, Linda C: 12 articles (04/2017 - 04/2005)
2.	Winkles, Jeffrey A: 11 articles (01/2021 - 04/2003)
3.	Tran, Nhan L: 8 articles (01/2021 - 04/2003)
4.	Ortiz, Alberto: 8 articles (01/2016 - 01/2008)
5.	Michaelson, Jennifer S: 7 articles (05/2015 - 04/2005)
6.	Culp, Patricia A: 6 articles (01/2018 - 01/2010)
7.	Ruiz-Ortega, Marta: 6 articles (01/2016 - 04/2008)
8.	Putterman, Chaim: 5 articles (05/2015 - 09/2004)
9.	Sanchez-Niño, Maria Dolores: 5 articles (02/2014 - 04/2008)
10.	Yagita, Hideo: 5 articles (07/2013 - 01/2002)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2013 - "Using immunohistochemistry (IHC), we found that TWEAK and its receptor Fn14 were expressed in human malignant ovarian tumors, but not in normal ovarian tissues or in borderline/benign epithelial ovarian tumors. " 01/01/2013 - "Functional expression of TWEAK and the receptor Fn14 in human malignant ovarian tumors: possible implication for ovarian tumor intervention." 01/01/2012 - "TWEAK activates the Fn14 receptor, and may regulate cell death, survival and proliferation in tumor cells. " 07/01/2011 - "TWEAK functions by binding its receptor, Fn14, which is up-regulated on many human solid tumors. " 01/01/2009 - "Initially identified as an inducer of tumor cell killing, TWEAK has pleiotropic effects, mediating proinflammatory and pro-angiogenic activity as well as stimulation of invasion, migration, and survival through its widely recognized receptor, Fn14. "
2.	Breast Neoplasms (Breast Cancer) 02/01/2013 - "The goal of the current study was to examine the potential of TweakR as a therapeutic target in breast cancer. " 10/01/2012 - "Thus, we identify LCN2 and TWEAKR-TWEAK as crucial downstream effectors of NFAT1 that regulate breast cancer cell motility and invasive capacity." 10/01/2012 - "We show, however, that TWEAKR mediates an anti-invasive effect in breast cancer cells whereas, depending on LCN2 expression, TWEAK has either anti- or pro-invasive capacities. " 02/01/2013 - "Overexpression of TweakR was observed in infiltrating tumors compared to normal adjacent breast tissues, and strong staining of TweakR was observed in all subtypes of invasive ductal breast cancer. " 02/01/2013 - "Expression of TweakR in primary breast cancer tissues and metastases was characterized using immunohistochemistry. "
3.	Rheumatoid Arthritis 06/01/2010 - "To investigate the mechanism of TWEAK on Rheumatoid arthritis fibroblast-like synoviocytes (RA FLS) activation and articular destruction by analyzing expression of TWEAKR/Fn14 on RA FLS. " 06/01/2010 - "[The expression of TWEAKR/Fn14 in Rheumatoid arthritis fibroblast-like synoviocytes]." 03/24/2011 - "This study aimed to investigate TWEAK and TWEAK receptor (Fn14) expression in synovial tissue from patients with active and inactive rheumatoid arthritis (RA), osteoarthritis (OA) and normal controls and assess soluble (s)TWEAK levels in the synovial fluids from patients with active RA and OA. " 01/01/2010 - "TWEAK and its receptor Fn14 in the synovium of patients with rheumatoid arthritis compared to psoriatic arthritis and its response to tumour necrosis factor blockade." 10/01/2012 - "To test this, we investigated the capacity of TWEAK to induce IL-17 production in T cells via the fibroblast growth factor-inducible gene 14 (Fn14, also known as TWEAK receptor) signal pathway in rheumatoid arthritis (RA). "
4.	Osteoarthritis 03/24/2011 - "This study aimed to investigate TWEAK and TWEAK receptor (Fn14) expression in synovial tissue from patients with active and inactive rheumatoid arthritis (RA), osteoarthritis (OA) and normal controls and assess soluble (s)TWEAK levels in the synovial fluids from patients with active RA and OA. "
5.	Keloid 07/01/2023 - "In this study, we found that the expression of both TWEAK and its cognate receptor Fn14 was significantly downregulated in keloids and that TWEAK/Fn14 signaling repressed the expression of ECM-related genes in keloid fibroblasts. "

Related Drugs and Biologics

1.	enavatuzumab
2.	Immunoglobulin G (IgG)
3.	Monoclonal Antibodies
4.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
5.	Fibroblast Growth Factors (Fibroblast Growth Factor)
6.	Proteins (Proteins, Gene)
7.	Cytokines
8.	Cytokine TWEAK
9.	NF-kappa B (NF-kB)
10.	Ligands

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics