Triggering Receptor Expressed on Myeloid Cells-1

An approximately 230 amino acid membrane glycoprotein characterized by an IMMUNOGLOBULIN V-SET DOMAIN in its N-terminal half. It is expressed by MONOCYTES and NEUTROPHILS in response to INFLAMMATION related to bacterial and fungal infections. It triggers the release of pro-inflammatory CHEMOKINES; CYTOKINES, and expression of cell activation markers and is a critical regulator of SEPTIC SHOCK.

Also Known As:

Networked: 368 relevant articles (4 outcomes, 42 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Gibot, Sébastien: 17 articles (01/2020 - 07/2004)
2.	Giamarellos-Bourboulis, Evangelos J: 9 articles (10/2021 - 01/2006)
3.	Derive, Marc: 9 articles (01/2021 - 02/2013)
4.	Bollaert, Pierre-Edouard: 7 articles (01/2007 - 07/2004)
5.	Gibot, Sebastien: 6 articles (06/2022 - 01/2007)
6.	Levy, Bruno: 6 articles (06/2022 - 07/2004)
7.	Wang, Ping: 6 articles (01/2022 - 01/2020)
8.	Bostanci, Nagihan: 6 articles (01/2021 - 10/2011)
9.	Cheon, Jae Hee: 6 articles (01/2021 - 07/2009)
10.	Kim, Tae Il: 6 articles (01/2021 - 07/2009)

Related Diseases

1.	Inflammation (Inflammations) 01/01/2023 - "This study sought to investigate the role of triggering receptor expressed on myeloid cells-1 (TREM-1) in the mechanotransduction signaling pathways that link low shear stress with inflammation. " 01/01/2023 - "Triggering receptor expressed on myeloid cells-1 (TREM1) has been shown to be a key regulator of inflammation. " 01/01/2023 - "Role of triggering receptor expressed on myeloid cells-1 in the mechanotransduction signaling pathways that link low shear stress with inflammation." 01/01/2022 - "Triggering receptor expressed on myeloid cells-1 (TREM-1) regulates inflammation and promotes a vigorous immune response. " 01/01/2022 - "Soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) is a soluble form of TREM-1 released during inflammation. "
2.	Infections 01/01/2016 - "Several studies have investigated the prognostic value of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in patients with infection. " 03/01/2018 - "Expression pattern of soluble triggering receptor expressed on myeloid cells-1 in mice with Acinetobacter baumannii colonization and infection in the lung." 05/01/2014 - "The soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) is a promising diagnostic marker for many types of infections. " 03/01/2014 - "TREM-1 (triggering receptor expressed on myeloid cells 1) amplifies inflammatory signaling during infection, but its role in KPLA is poorly understood. " 01/01/2013 - "In the setting of infection, neutrophil triggering receptor expressed on myeloid cells 1 (TREM-1) amplifies inflammatory signaling. "
3.	Critical Illness (Critically Ill) 01/01/2022 - "Relationships Between Age, Soluble Triggering Receptor Expressed on Myeloid Cells-1 (sTREM-1), and Mortality Among Critically Ill Adults: A Cohort Study." 06/01/2012 - "The plasma level of soluble triggering receptor expressed on myeloid cells 1 (sTREM-1) has been shown to be helpful in identifying critically ill patients with infection. " 03/01/2013 - "Diagnostic value of soluble triggering receptor expressed on myeloid cells-1 in critically-ill, postoperative patients with suspected sepsis." 06/01/2012 - "To define early kinetics of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) and of TREM-1 monocyte gene expression in critically ill patients with sepsis. " 05/06/2015 - "Diagnostic value of neutrophil gelatinase-associated lipocalin, cystatin C, and soluble triggering receptor expressed on myeloid cells-1 in critically ill patients with sepsis-associated acute kidney injury."
4.	Reperfusion Injury 06/01/2015 - "Pharmacological inhibition of the triggering receptor expressed on myeloid cells-1 limits reperfusion injury in a porcine model of myocardial infarction." 01/01/2020 - "Thus, blocking the extracellular cold-inducible RNA-binding protein-triggering receptor expressed on myeloid cells-1 interaction is a promising therapeutic avenue for mitigating intestinal ischemia-reperfusion injury." 01/01/2020 - "Inhibition of a triggering receptor expressed on myeloid cells-1 (TREM-1) with an extracellular cold-inducible RNA-binding protein (eCIRP)-derived peptide protects mice from intestinal ischemia-reperfusion injury." 01/01/2020 - "Inhibition of triggering receptor expressed on myeloid cells-1 by an extracellular cold-inducible RNA-binding protein-derived small peptide (M3) decreased inflammation, reduced lung injury, and improved survival in intestinal ischemia-reperfusion injury. "
5.	Lung Injury 01/01/2020 - "Inhibition of triggering receptor expressed on myeloid cells-1 by an extracellular cold-inducible RNA-binding protein-derived small peptide (M3) decreased inflammation, reduced lung injury, and improved survival in intestinal ischemia-reperfusion injury. "

Related Drugs and Biologics

1.	Peptides (Polypeptides)
2.	RNA-Binding Proteins (RNA-Binding Protein)
3.	Procalcitonin
4.	C-Reactive Protein
5.	Biomarkers (Surrogate Marker)
6.	Interleukins
7.	Cytokines
8.	Interleukin-6 (Interleukin 6)
9.	Proteins (Proteins, Gene)
10.	Reactive Oxygen Species (Oxygen Radicals)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Critical Care (Surgical Intensive Care)
4.	Renal Replacement Therapy (Therapies, Renal Replacement)
5.	Punctures